The “matrix effect” is one of the sticky details that can make the use of liquid chromatography (LC) for quantitative purposes challenging, even though it is conceptually quite straightforward. In this installment of LC Troubleshooting, Dwight Stoll reviews what is being referred to during talks about “matrix effects”, and discusses some of the potential origins of the phenomenon in practice.
During Waters Corporation’s 2025 Investor Day, the company’s top executives highlighted the company’s growth and hints at future points of development.
Here is some of the most popular content posted on LCGC International this week.
In the final section of our interview with Christopher Pohl, he imparts knowledge to the next generation of aspiring separation scientists.
In this month's edition of the LCGC Blog, Emanuela Gionfriddo discusses chromatography resources that can help make the field more accessible to newcomers and veterans alike.
In this penultimate section of our interview with Christopher Pohl, he reflects on the history of chromatography, sharing what he deems the most important moments in the field.
LCGC International spoke to Paul-Albert Schneide and Oskar Munk Kronik about the development and application of a novel two-step workflow—mass filtering (MF) combined with multivariate curve resolution (MCR)—for extracting clean mass spectra from trace-level compounds in LC×LC–HRMS data.
Here is some of the most popular content posted on LCGC International this week.
Scientists from Bristol Myers Squibb developed a method using supercritical fluid chromatography for chiral bioanalysis.
Here is some of the most popular content posted on LCGC International this week.
Ardiana Kajtazi discusses her research identifying organic micropollutants in water using liquid chromatography–high-resolution mass spectrometry (LC–HRMS). She highlights the standardized filtration approach her team has developed based on intersection principles, utilizing retention indices from two reversed-phase liquid chromatography (RPLC) columns.
A two-step workflow to extract pure mass spectra from comprehensive two-dimensional liquid chromatography high-resolution mass spectrometry (LC×LC–HRMS) data has been created and tested.
The Harvey W. Wiley Award is presented every year to a scientist, or group of scientists, who have made outstanding contributions to analytical method development in areas of interest to AOAC INTERNATIONAL.
A team of researchers has evaluated approaches in exposome research, highlighting sample preparation, MS-based platforms, and data acquisition strategies.
A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.
To honor the 2025 International Day of Women and Girls in Science, the editors of LCGC share highlights from our series done in collaboration with Females in Mass Spectrometry (FeMS) group.
In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used for LC methods involving UV absorbance detection.
ACD/Labs recently released their 2025 Structure Elucidation & Verification Report, discussing how informatics trends have shifted since 2022.
Labomatic Instruments and Knauer recently announced a new strategic cooperative relationship to offer their instrument portfolios to each other’s customer bases.
Here is some of the most popular content posted on LCGC International this week.
You're invited to publicize your 2024–2025 new product introductions in LCGC. Here's how to get your products included.
A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.
University of Turin scientists developed a UHPLC–PDA-MS/MS-based method for quantifying plant-specialized metabolites for determining the quality of medicinal and aromatic plants.
