Liquid Chromatography (LC/HPLC)

Ardiana Kajtazi discusses her research identifying organic micropollutants in water using liquid chromatography–high-resolution mass spectrometry (LC–HRMS). She highlights the standardized filtration approach her team has developed based on intersection principles, utilizing retention indices from two reversed-phase liquid chromatography (RPLC) columns.

A two-step workflow to extract pure mass spectra from comprehensive two-dimensional liquid chromatography high-resolution mass spectrometry (LC×LC–HRMS) data has been created and tested.

The Harvey W. Wiley Award is presented every year to a scientist, or group of scientists, who have made outstanding contributions to analytical method development in areas of interest to AOAC INTERNATIONAL.

A team of researchers has evaluated approaches in exposome research, highlighting sample preparation, MS-based platforms, and data acquisition strategies.

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

To honor the 2025 International Day of Women and Girls in Science, the editors of LCGC share highlights from our series done in collaboration with Females in Mass Spectrometry (FeMS) group.

In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used for LC methods involving UV absorbance detection.

ACD/Labs recently released their 2025 Structure Elucidation & Verification Report, discussing how informatics trends have shifted since 2022.

Labomatic Instruments and Knauer recently announced a new strategic cooperative relationship to offer their instrument portfolios to each other’s customer bases.

Here is some of the most popular content posted on LCGC International this week.

You're invited to publicize your 2024–2025 new product introductions in LCGC. Here's how to get your products included.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.

University of Turin scientists developed a UHPLC–PDA-MS/MS-based method for quantifying plant-specialized metabolites for determining the quality of medicinal and aromatic plants.

Paris-Saclay University scientists used hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS) and inductively coupled plasma mass spectrometry (ICP-MS) to assess thorium’s interaction with peptides.

In this edition of The LCGC Blog, Jonathan Shackman discusses what factors to consider when choosing a mobile phase for liquid chromatography (LC) procedures.

New methods have been developed to determine polar emerging contaminants with hydrophilic interaction liquid chromatography (HILIC) techniques.

University College London scientists recently created a new technique for selecting two-dimensional liquid chromatography (2D-LC) columns.

Scientists from the Henan Academy of Sciences recently developed a new technique for the determination of hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) from urine.

A new process for tracking targeted and non-targeted fluorinated residuals using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) has been created.

An investigation into fluoroelastomer watch bands has revealed high levels of perfluorohexanoic acid (PFHxA), a short-chain per- and polyfluoroalkyl substance (PFAS). LCGC International spoke to Professor Graham Peaslee from the University of Notre Dame about his team’s study using liquid chromatography tandem mass spectrometry (LC–MS/MS) and PFHxA's potential for dermal absorption, and the subsequent environmental and health impacts.

Scientists from the National Institutes for Food and Drug Control have characterized antibody-drug conjugates (ADCs) using various mass spectrometry (MS)-based techniques.

“Forever chemicals” per- and polyfluoroalkyl substances (PFAS) have been found in smartwatch and fitness bands and analyzed using liquid chromatography tandem mass spectrometry (LC–MS/MS) and direct total oxidative precursor (dTOP) assay.

Here is some of the most popular content posted on LCGC International this week.

Scientists recently studied how different factors affect antisense oligonucleotides (ASOs) under hydrophilic interaction liquid chromatography (HILIC) conditions.