Liquid Chromatography (LC/HPLC)

In this month’s column, I highlight some of the primary considerations we face in method development and point to resources that can help users overcome uncertainty and develop highly effective 2D-LC methods.

Here are the top five articles that the editors of LCGC International published this week.

The “farmer-managed natural regeneration,” or FMNR, project has been ongoing for more than two years, aimed at re-greening deforested land.

In the world of liquid chromatography, innovative strides in column technology continue to take place. We are also reminded that there is always more to learn about “well-known” methodologies, and our craft is continuously influenced by important social concerns.

Governments are striving to implement policy changes towards a greater use of green technology, specifically around the generation of energy. Individuals and industrial organizations have also taken up the challenge, and now many companies are driving to significantly reduce their environmental footprint, or indeed become carbon negative within very short time frames.

An unexpected retention order for ketamine analogs was observed when using a biphenyl stationary phase for liquid chromatography-mass spectrometry (LC–MS).

In this edition of The LCGC Blog, Emanuela Gionfriddo discusses the two world-class scientists and trailblazer women in separation chemistry and the awards they received at Pittcon 2024.

Tony Edge, Stephane Moreau, Carsten Paul, and Fraser McLeod discuss the latest trends and developments in LC.

How long should you perform an extraction of woodruff leaves so that you don’t end up with a harmful amount of coumarin, but still get the characteristic flavor of the finished May wine?

LCGC’s Senior Technical Editor uses artificial intelligence (AI) platform ChatGPT to answer questions about the role of AI in separation science. Do you agree with ChatGPT?

As opposed to targeted metabolomics which looks only at a predetermined set of metabolites or their pathways, an untargeted approach was preferred by this research team because of its unbiased yet still comprehensive nature.

Are you a chromatographer or a chromatography user?

In preparation for ASMS 2024, we recently interviewed Uri Keshet of the University of California, Davis about his upcoming presentation and expectations for the conference.

Here are the top five articles that the editors of LCGC International published this week.

During the 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, experts presented a workshop on different ways multidimensional liquid chromatography can be applied.

Here are the top five articles that the editors of LCGC International published this week.

The flowmeter, Testa said in a press release, was compared favorably as an alternative to more traditional flow calibration methods for HPLC pumps.

Scientists from Wuhan Textile University recently tested a new solid-phase extraction system for analyzing covalent organic frameworks (COFs).

In this interview for ASMS 2024, Liusheng Huang of the University of California San Francisco discusses his upcoming presentation about performing microvolume analysis on antimalarial drugs.

Xinyi Biyan is a Chinese patent medicine with significant therapeutic effects, widely used clinically to treat acute and chronic rhinitis or allergic rhinitis.

Scientists from Changchun University of Chinese Medicine used UHPLC-Q-Orbitrap-MS/MS analysis to identify the active compounds in TongFu XieXia Decoction for treating intestinal obstruction.

Scientists from the Lunan Pharmaceutical Group explored the use of UHPLC-MS/MS to test the effects of Shouhui Tongbian capsules (SHTBs) on slow transit constipation (STC).

Scientists from the Shenyang Pharmaceutical University in China have developed a new quality assessment system for various types of traditional Chinese medicine (TCM).

Scientists from Chongqing University Cancer Hospital recently developed a new system for analyzing the potential impact of retention time (RT) prediction on targeted LC–MS-based lipidomics.

Brivaracetam has been approved for prescription use in the last decade for treatment of patients experiencing focal, or partial, seizures.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from Florida State University used Marfey’s reagent and reversed-phase liquid chromatography–tandem mass spectrometry (LC–MS/MS) to analyze D-amino acids.

In this installment, we apply the concepts developed in last month’s installment by demonstrating how they can be used to help troubleshoot problems in LC involving pressure and flow.

This article covers liquid chromatography columns and accessories commercially released after Pittcon 2023 through the 2024 conference.

Recent advances in coating techniques and improved polymers employed as gas chromatographic stationary phases have resulted in commercializing low phase ratio capillary column technology with respectable chromatographic efficiency and inertness.