Liquid Chromatography (LC/HPLC)

At HPLC 2025 in Bruges, Belgium LCGC International interviewed a member of our editorial advisory board (EAB), Paul Ferguson, a leading voice in sustainability in the pharmaceutical sector, to explore the intersection of green chemistry and emerging therapeutics.

LCGC International interviewed Professor Torgny Fornstedt, Professor in Analytical Chemistry & Leader of the Fundamental Separation Science Group at Karlstad, Sweden at HPLC 2025 in Bruges, Belgium.

LCGC International interviewed Torgny Fornstedt, Professor in Analytical Chemistry & Leader of the Fundamental Separation Science Group at Karlstad University, Sweden at HPLC 2025 in Bruges, Belgium on modern separation methods to analyse oligonucleotides.

To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was used to quantify antitumor prodrugs and their metabolites.

Bo Zhang, associate professor at Xiamen University, China, spoke to LCGC International at HPLC 2025 in Bruges, Belgium, about his recent research on a novel elastic connection technology—macroporous polyacrylamide hydrogel septum (MAPS)—which was developed as a complementary solution for capillary column interfacing in liquid chromatography.

Using two-dimensional liquid chromatography–mass spectrometry, a new workflow was developed to characterize phosphorodiamidate morpholino oligomers, which can help treat infectious diseases.

LCGC International interviewed Bob Pirok from the University of Amsterdam, Netherlands to discuss strategies for enhancing method robustness in 2D LC, practical approaches for tracking peaks across complex data sets, and the role of machine learning and AI in chromatography.

Scientists from the Technical University of Munich and Lund University explored the use of new models for liquid-liquid chromatography based off pre-existing procedures for liquid-liquid extraction.

Recently, we spoke with Esther Olonimoyo from the University of Maryland, who recently published a study using high-performance liquid chromatography to analyze short chain fatty acids.

To better detect polycyclic aromatic hydrocarbons in the human body, a UHPLC–MS/MS method was developed and tested on urine samples from workers exposed to diesel exhaust.

To quantify antibiotics in ICU patients’ blood, dried blood spot analysis was sued alongside UHPLC–MS/MS to monitor these substances in a more convenient matter.

In a new study, researchers explored a new approach for detecting pesticide residues in water samples, based around ionic liquid-based dispersive liquid–liquid microextraction (IL-DLLME).

A new analysis method for detecting bisphenols in environmental sources was tested using loofah sponges and solid-phase extraction.

In a new study, researchers used GC–MS and LC–MS were used to detect composition fraud in food supplement creation.

A new dried spot-based technique involving untargeted liquid chromatography coupled with high-resolution mass spectrometry was testing for characterizing foodstuffs.

A high-throughput workflow for wide-targeted metabolomics in dried blood spots (DBS) is presented.

An investigation into whether 3D-printed sorbent devices introduce background contaminants in untargeted LC–QTOF-MS analyses.

This study delves into the challenges of online coupling, offering solutions to overcome peak distortion and enhance reliability in complex sample analysis. The resulting LC×SFC–MS/MS analysis allows differentiation of isomers in very complex samples, regardless of similar fragmentation patterns.

In this interview, Caroline West, professor at the University of Orléans and an active member of LCGC International’s editorial advisory board, discusses current perspectives on the fundamentals of SFC.

This article explores the use of chromatographic retention measurements in both LC and SFC to develop quantitative retention activity relationship (QRAR) models, offering a predictive tool for skin permeability without animal testing.

Discover a novel GC-based method for accurately analyzing organic carbonates in lithium-ion batteries without the need for complex calibrations.

This article explores the technological advancements in HPLC that enhance its role in analyzing PFAS in food, including innovations in column technology, detection systems, and sample preparation techniques.

In this interview, Gesa Schad from Shimadzu Europe, Germany, discusses how SFC is being used in practice, why she launched SFC For Dummies at HPLC 2025, and how common misconceptions surrounding the robustness of SFC have been addressed some time ago.

New upgrades to the Waters Corporation Alliance iS HPLC System Software systems were recently discussed at HPLC 2025.

Here is some of the most-read content posted on LCGC International this week.