Liquid Chromatography (LC/HPLC)

In this article, you’ll find some of the top content that was published on LCGC this week, including our upcoming forensic science content series and an interview on preanalytical factors for ethanol testing.

Researchers at the Institute of Marine Research in Bergen, Norway used liquid chromatography–mass spectrometry to analyze resolvins in fish and human cells.

Johns Hopkins University researchers, in response to many high performance liquid chromatography (HPLC) systems having issues with peak resolution, created their own system for quantifying complex HPLC chromatograms.

Antiretroviral drug residues were monitored in breastmilk samples using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS).

Researchers from Sapienza Università di Roma and ETH Zürich investigated the performance of micro- and nano-liquid chromatography systems by examining how capillary LC behaves under varying operational conditions.

Bioactive compounds extracted from plants are revered for their abilities to enhance human health. However, due to the complex matrices of plant foods, the qualitative and quantitative analysis of metabolites in plant foods requires a prior separation step.

Smokeless powders can be vital aspects of forensic investigations, though distinguishing between different powders can prove difficult. Chinese researchers aimed to simplify this process using gel permeation chromatography.

To better analyze components from chaga (Inonotus obliquus) mushrooms, researchers created a supercritical fluid chromatography (SFC)-based approach to collecting and quantifying chaga components.

Universitat de Barcelona researchers have developed a new method for characterizing solute-solvent interactions in electrokinetic systems.

The components of explosive devices can be difficult to characterize, whether pre- or post-blast. To rectify this, two-dimensional liquid chromatography was tested as a means of analyzing these compounds.

To better analyze polyphenols, scientists from Sapienza University of Rome examined the capabilities of supercritical fluid chromatography (SFC), comparing it to traditional methods.

In this article, you’ll find some of the top content that was published on LCGC this week, including details on the recent merger between Waters Corporation and BD Biosciences.

Salvia is an herb that is utilized in various industries. High-performance thin-layer chromatography was used to analyze different Salvia extracts.

Circular dichroism and fluorescence were used to create a platform for monitoring changes in monoclonal antibodies.

Shifts in U.S. federal science funding—driven by the newly established Department of Government Efficiency (DOGE)—are causing delays, uncertainty, and program changes across academic and regulatory research institutions.

At HPLC 2025 in Bruges, Belgium LCGC International interviewed a member of our editorial advisory board (EAB), Paul Ferguson, a leading voice in sustainability in the pharmaceutical sector, to explore the intersection of green chemistry and emerging therapeutics.

LCGC International interviewed Professor Torgny Fornstedt, Professor in Analytical Chemistry & Leader of the Fundamental Separation Science Group at Karlstad, Sweden at HPLC 2025 in Bruges, Belgium.

LCGC International interviewed Torgny Fornstedt, Professor in Analytical Chemistry & Leader of the Fundamental Separation Science Group at Karlstad University, Sweden at HPLC 2025 in Bruges, Belgium on modern separation methods to analyse oligonucleotides.

To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) was used to quantify antitumor prodrugs and their metabolites.

Bo Zhang, associate professor at Xiamen University, China, spoke to LCGC International at HPLC 2025 in Bruges, Belgium, about his recent research on a novel elastic connection technology—macroporous polyacrylamide hydrogel septum (MAPS)—which was developed as a complementary solution for capillary column interfacing in liquid chromatography.

Using two-dimensional liquid chromatography–mass spectrometry, a new workflow was developed to characterize phosphorodiamidate morpholino oligomers, which can help treat infectious diseases.

LCGC International interviewed Bob Pirok from the University of Amsterdam, Netherlands to discuss strategies for enhancing method robustness in 2D LC, practical approaches for tracking peaks across complex data sets, and the role of machine learning and AI in chromatography.

Scientists from the Technical University of Munich and Lund University explored the use of new models for liquid-liquid chromatography based off pre-existing procedures for liquid-liquid extraction.

Recently, we spoke with Esther Olonimoyo from the University of Maryland, who recently published a study using high-performance liquid chromatography to analyze short chain fatty acids.

To better detect polycyclic aromatic hydrocarbons in the human body, a UHPLC–MS/MS method was developed and tested on urine samples from workers exposed to diesel exhaust.