Mass Spectrometry

Researchers have developed a 3D tumor-immune cell coculture spheroid model combined with mass spectrometry (MS) imaging-based spatially resolved metabolomics, offering insights into metabolic alterations during antitumor immune responses.

Webinar Date/Time: Thu, Jan 11, 2024 11:00 AM EST

A novel lenvatinib stability-indicating method, developed through a quality by design (QbD) approach and embracing principles of green chemistry, offers a robust solution for ensuring the drug's stability under various conditions.

Researchers have developed a meticulous method for analyzing impurities in a product used for early treatment of breast cancer in premenopausal and perimenopausal women, shedding light on the product’s degradation pathways.

L-thryoxine was proposed as the label at the end of a DNA aptamer that comprised a reporter agent complementary to a capture agent in this experimental design.

Three different metrics were used experimentally, based on measurements of both NIST Standard Reference Material (SRM) 1950 and data obtained from murine kidney tissue.

Scott Fenwick, technical director of Clean Fuels Alliance America, was the keynote speaker at the Gulf Coast Conference in Galveston, Texas, where he held a lecture on the growth of biomass-based fuels.

In a recent study, researchers used a dual-isotope labeling method to help improve our understanding of lipid metabolism.

Researchers from the University of Florida have employed gas-phase charge inversion ion/ion reactions to distinguish isobaric lipids in imaging mass spectrometry, offering enhanced molecular specificity for analyte identification.

Researchers at two US colleges have utilized ion mobility spectrometry–mass spectrometry (IMS-MS) to analyze nonenzymatic posttranslational modifications and peptide cleavages in a single peptide system, revealing insights into critical biomarkers for age-related diseases.

FDA scientists have expanded the number of analytes in their analytical method for per- and polyfluoroalkyl substances (PFAS), partly in response to updated guidance out of the European Union (EU) on method parameters and limits of quantification (LOQs).

Researchers in Tianjin, China, have employed all ion unfolding–ion mobility–mass spectrometry (AIU–IM–MS) to enhance the differentiation of therapeutic polyclonal antibodies, offering insights into improvements in conformational stability and advantages in cost-effectiveness.

Valérie Pichon's review in Analytical and Bioanalytical Chemistry delves into sophisticated liquid chromatography techniques for detecting albumin adducts, vital biomarkers in retrospective mustard agent exposure monitoring, offering a broader window of detection than urine-based methods.

A comprehensive analytical approach utilizing online two-dimensional liquid chromatography coupled with hybrid linear ion trap orbital trap mass spectrometry, has enabled the in-depth analysis of Huangqi Guizhi Wuwu decoction, identifying 170 chemical constituents and offering insights into its complex chemical composition and potential therapeutic properties.

A molecular dynamics trajectory approach was shown by a research team to improve ion mobility predictions with deviations of mere percentage points from experimental values.

A research team from India recently explored how GC–MS can help target the metabolic profile of IM-resistant chronic myeloid leukemia (CML) cells.

At HPLC 2023, John Langley, a professor at the University of Southampton in Southampton, UK, presented a talk called "(R)evolution of Hyphenations, Through Open-Access RP-HPLC–MS, Open-Access UHPSFC–MS and 2D-LC–IMS-MS in Academia". He spoke with LCGC on the importance of open-access hyphenation, and how to implement it in your research.

The benefits and challenges of using hydrogen in the laboratory, specifically regarding GC and GC–MS procedures, are discussed.

Researchers from the University of Poitiers and CNES have developed a groundbreaking gas chromatography method, detailed in the journal Chemosensors, which enables the detection of amino acid-like compounds on Mars, offering a vital tool in the quest for extraterrestrial life.

Scientists from the University of Utah in Salt Lake City, Utah, created a new technique to characterize lipids, specifically glycolipids, using ion mobility spectrometry–mass spectrometry (IMS-MS).

Untargeted analysis using liquid chromatography with tandem mass spectrometry (LC–MS/MS) chemical profiling is a valuable tool, but care needs to be taken with experimental design.

Scientists used supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—to analyze various types of chlorinated paraffins (CPs) in fish oil-based dietary supplements.

How can low-resolution mass spectrometry (LRMS) and high-resolution (HR) MS work together to provide unambiguous results in clinical and forensic toxicology?

The author discusses the benefits and challenges of using hydrogen in the laboratory, specifically regarding gas chromatography and GC–MS procedures.

The methodologies demonstrated here open the way to fully compliant at-line monitoring of monoclonal antibody quality attributes.

An overview of GLP regulations and related public standards.

Results from our recent survey on sample preparation techniques uncover trends in the field over the last generation and their impact going forwards.

Alasdair Matheson spoke to Jacob de Boer of Vrije Universiteit Amsterdam about a recent innovative research project investigating per- and polyfluoroalkyl substances (PFAS) in fast food packaging.

Researchers have developed a multitargeted internal calibration method for precise quantification of chronic kidney disease (CKD)-related endogenous metabolites using liquid chromatography–mass spectrometry (LC–MS).

To analyze circulating tumor cells (CTCs) more efficiently in clinical whole blood samples, a team of scientists from Chengdu, China, created their own simplified CTC analysis system.