November 8th 2024
Here is some of the most popular content posted on LCGC International this week.
New LC–MS/MS Data Analysis Framework, MCnebula, Streamlines Untargeted Analysis
June 29th 2023Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.
New Approach for Tandem Mass Spectrometry Precursor Selection
June 29th 2023A research team has developed a new approach for selecting precursor ions in tandem mass spectrometry (MS/MS) experiments called DiffN, which increases the likelihood of biomarker discovery and provides a promising tool for lipidomic analyses.
Revolutionary Interferometric Mass Spectrometry Unleashes New Possibilities in Mass Separation
June 27th 2023With the potential for compact mobile devices, interferometric mass spectrometry (Interf-MS) is a pioneering technique that utilizes quantum interference and wave-like properties of samples for mass separation, offering a high dynamic range and complementing traditional methods such as accelerator mass spectrometry (AMS).
UHPLC–MS/MS Quantifies Ultraviolet Filter Compounds in Chlorinated Canadian Waters
June 16th 2023An ultrahigh-pressure liquid chromatography–tandem mass spectrometry method (UHPLC–MS/MS) using polarity switching, preceded by solid-phase extraction (SPE), was used to quantify eight ultraviolet filter (UVF) compounds in chlorinated outdoor pools in Winnipeg.
Breakthrough MDLC–MS Method Enhances Characterization of Therapeutic Antibody Charge Variants
June 16th 2023Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.
Unveiling Metabolite Interference for Reliable LC–MS Targeted Metabolomics Analysis
June 15th 2023New research emphasize the importance of identifying metabolite interference in LC–MS targeted metabolomics analysis to ensure accurate results. The study highlights the need for thorough investigation and resolution of metabolite interferences for reliable metabolite measurement in targeted metabolomics.
Breakthrough Method Enables Discovery of Natural Aldehydes for Metabolomics Research
June 14th 2023The development of a newly-designed Girard's reagent, HBP, as charged isobaric mass tags has enabled selective capture and sensitive detection of aldehyde metabolites. The LC–dNLS-MS/MS screening approach using this reagent has successfully facilitated the discovery of natural aldehydes and their profiling in complex samples.