Pharmaceutical Analysis

Pharmaceutical excipients, such as polyethylene glycol-based polymers, must be tested for the presence of ethylene oxide (EtO) and 1,4-dioxane as part of a safety assessment, according to USP Chapter <228>.

Webinar Date/Time: September 12, 2024 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST

Ion chromatography (IC) is becoming increasingly important for pharmaceutical applications. In contrast to other technologies, IC can resolve multiple ionic species and polar analytes simultaneously.

Steven Ray Wilson and Hanne Røberg-Larsen of the University of Oslo recently discussed the practical application and advantages of their FDA-validated research to analyse small molecule drugs and their metabolites in organoid/organ-on-chip systems that serve as alternatives to animal models.

Here are the top five articles published on LCGC International this week.

Webinar Date/Time: Wed, Aug 28, 2024 11:00 AM EDT

Webinar Date/Time: Thu, Sep 5, 2024 11:00 AM EDT

During a presentation at the conference in Denver, Colorado scientists from Merck and Novilytic spoke about chromatography techniques used for different kinds of pharmaceutical analysis.

Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.

Webinar Date/Time: Wed, Aug 7, 2024 11:00 AM EDT

LCGC International spoke with Quang-Dong Bui, a second-year PhD student at Vrije Universiteit Brussels to discuss his work in oligonucleotide analysis.

The editors of LCGC International highlight open roles for scientists in pharmaceuticals, instrument manufacturing, and more.

This article describes the contents and associated calculations of CoAs for small-molecule drugs. It explains how these documents help to ensure drug quality in the supply chain.

We interview Serge Rudaz of the University of Geneva about the upcoming 34th International Symposium on Pharmaceutical and Biomedical Analysis.

Here are the top five articles that the editors of LCGC International published this week.

In this interview for ASMS 2024, Liusheng Huang of the University of California San Francisco discusses his upcoming presentation about performing microvolume analysis on antimalarial drugs.

Scientists from the University of Messina recently developed a new omega-3 fatty acid-based supplement and tested its effectiveness on metabolism and lipid profiles.

Researchers have utilized ultra-high performance liquid chromatography-tandem mass spectrometry (UH PLC-MS/MS) to monitor 5-Fluorouracil, a medication used to treat various cancers, in dried blood spots. This process offers a simpler, more efficient method than those in place involving the monitoring of plasma.

HRIM-MS has shown unique capabilities when used to analyze cyclic peptide therapeutics, and enhances the analysis of biopharmaceuticals by efficiently filtering out interfering compounds for direct analysis within a complex mixture. These findings demonstrate the technique's utility and versatility.

Here are the top five articles that the editors of LCGC International published this week.

Researchers at Enveda Biosciences are transforming nature into new medicines with their artificial intelligence (AI)-enabled industrial-scale drug discovery platform incorporating tandem mass spectrometry (MS/MS).

Element Materials Technology introduced its Rapid Response Pharmaceutical Testing Service, providing expedited testing and focusing on various requirements including active ingredients and final drug products, extractables and leachables, degradation production, and elemental impurities.

The company’s new service will provide expedited testing to customer around the world.

Webinar Date/Time: Monday, April 15, 2024 and Tuesday, April 16, 2024 Morning Session: 10:00am - 12:15pm Lunchtime Session: 12:30pm - 1:15pm Afternoon Session: 2:00pm - 4:00pm

This month we interview Shijia Tang, principal scientist at Genentech, South San Francisco, CA, USA, about her innovative research focusing on the analysis of polymers and nanomaterials used in pharmaceutical analysis. Shijia decribes the benefits of an innovative in-line mixing modulation method for 2D-LC she developed for polymer and oligonucleotide analysis. The advantages of SEC–MALS to explore aggregation mechanisms for therapeutic constrained peptides and mRNA-lipid nanoparticles and their aggregates are also discussed.