Enhancing High-Throughput HPLC Methods for Small-Molecule Drug Discovery Using Superficially Porous Particle Technology
Researchers Develop Innovative Strategy for Countercurrent Chromatography Separation of Sanshools From Zanthoxylum bungeanum Oleoresin
Metabolic Perturbation Score-Based Mass Spectrometry Imaging (MPS-MSI) offers spatially resolved insights into the functional metabolic response, facilitating a deeper understanding of disease progression and drug action, and paving the way for improved therapeutic strategies and targeted interventions.
Scientists have developed an automatic and highly efficient method to authenticate single herbal powders using microscopy-guided in situ auto-sampling combined with matrix-assisted laser desorption–ionization mass spectrometry (MALDI–MS).
A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.
A new article discusses the benefits and drawbacks of RPLC and RPLC×RPLC chromatography techniques. It provides recommendations for selecting the best approach for analyzing small pharmaceuticals and peptides.
Scientists have developed a magnetic ionic liquid hypercrosslinked polymer composite for use in magnetic solid-phase extraction (MSPE) of non-steroidal anti-inflammatory drugs (NSAIDs), which was coupled with high-performance liquid chromatography (HPLC) for the detection of trace amounts of NSAIDs in water and urine samples.
New article reviews the progress in suppression techniques for ion chromatography from 1981 to 2022, with an emphasis on the last ten years, and discusses the current challenges and future prospects regarding suppressors.
Scientists propose a gel-free hybridization assay using peptide nucleic acid (PNA) probes and capillary electrophoresis (CE) for qualitative and quantitative analysis of nucleic acid therapeutics.
Researchers have developed a new model for achiral chromatography (ACh) that can separate non-racemic mixtures of enantiomers.
In the first of a two-part series, a recent study discusses a new strategy for assessing the peak purity of pharmaceutical peptides analysis using 2D-LC–MS.
Webinar Dates/Times: Session 1 (EU): Wednesday, May 17th, 2023 at 2pm BST | 3pm CEST | 9am EDT Session 2 (NA): Wednesday, May 17th, 2023 at 1pm EDT | 10am PDT | 6pm BST Session 3 (APAC): Thursday, May 18th, 2023 at 12pm JST | 11am CST | 11pm EDT
Sartans are important drugs that help treat hypertension and heart failure. However, since their recall in 2018 because of the presence of genotoxic impurities in these drugs, researchers are tackling the question of how to detect these impurities in these drugs before they go to market. This article describes a HPLC–APCI-MS/MS method that can help in this endeavor.
Solid-phase microextraction combined with mass spectrometry improves our ability for rapid drug screening.
SIFT–MS analysis has potential to screen large numbers of packaging samples for the volatile MOH fraction, providing a rapid indication of packaging material contamination.
The current challenges and future perspectives of the purification of cannabinoids from cannabis extracts are presented in this review article.
Webinar Date/Time: Wednesday, April 19, 2023
Fasha Mahjoor will receive the 2023 Pittcon Heritage Award, which honors prominent figures in the scientific community. Pittcon 2023 will take place from March 18–22 in Philadelphia, Pennsylvania.
A new automated active pharmaceutical ingredient (API) extraction approach with integrated analysis by online liquid chromatography (LC) to assess drug product potency is presented.
Webinar Date/Time: Day One, Monday, March 13, 2023 Day Two, Tuesday, March 14, 2023 Day 1: 10:00 am – 4:30 pm EST Day 2: 10:00 am – 4:30 pm EST
Webinar Date/Time: Thu, Mar 2, 2023 11:00 AM EST
Webinar Date/Time: Wed, Jan 25, 2023 11:00 AM EST
Webinar Date/Time: Airing 1: Tuesday January 17, 2023 at 9am EST | 2pm GMT | 3pm CET Airing 2: Tuesday January 17, 2023 at 2pm EST | 1pm CST | 11am PST
Webinar Date/Time: Thu, Dec 15, 2022 11:00 AM EST
Webinar Date/Time: Monday, November 28 2022 at 11 am EDT
The Column spoke to Brett Paull from the University of Tasmania in Hobart, Australia, about the development of truly portable LC systems for use in the pharmaceutical industry and in environmental analysis. Why are they necessary, and where can improvements still be made?
This case study of the career path of a separation scientist illustrates the diversified roles of an analytical chemist in nonclinical drug development.
