November 20th 2023
In this LCGC Blog, Muhammad Farooq shares some tips for entering different careers within the analytical chemistry industry.
November 10th 2023
Scientists from Egypt have developed a green reversed-phase high-performance liquid chromatography (RP-HPLC) method to determine the amounts of methionine and paracetamol in different mixtures.
November 8th 2023
To better understand the purity of therapeutic peptides, scientists from Germany, studied the effects supercritical fluid chromatography (SFC) could have during the analysis.
November 6th 2023
A team of scientists from Taizhou, China have developed a means of studying the medical effects of Qiangxin Lishui Prescription (QLP).
September 18th 2023
Scientists from the National Institute of Pharmaceutical Education and Research (NIPER) in India used a variety of techniques to characterize erdafitinib and its various products.
Understanding the Behaviour of Pharmaceutical Polymers
This article discusses GPC and gives examples of the use of the technique in excipient analysis.
Radio Ion Chromatography
Metrohm Application Note
Size-Exclusion Ultra Performance Liquid Chromatography Analysis of Insulin
Waters Application Note
Maximizing HPLC Productivity with 2.5 µm Extended Performance (XP) Columns
Fast Screening Methods for Beta Blockers by HPLC with Agilent Poroshell 120 Columns
Agilent Application Note
Reference Materials - Why Quality Matters
Access to a comprehensive source of certified reference materials in various forms - powders and solutions - is vital for clinical and forensic laboratories, to ensure the correct identification of substances and the accuracy of results, and there is an increasing customer demand for ISO Guide 34:2009 certification. Jenny Button, Product Specialist, LGC Standards, UK, discusses certified reference materials and the importance of ISO Guide 34 to both manufacturers and end-users.
Quantitative Analysis of Drugs of Abuse in Urine Using UHPLC Coupled to A TOF Mass Spectrometer
Human beings have long consumed mind altering drugs to attain a euphoric high. These illegal drugs are obtained directly from natural substances including plants or they are chemically synthesized. Monitoring consumption of abused drugs is important in workplace settings, crime scene investigations, forensic toxicology and other related areas.
Capillary Electrophoresis–Mass Spectrometry for the Analysis of Biopharmaceuticals
CE–MS using noncovalent coated capillaries provides advantages for purity and stability analysis of biopharmaceuticals.
Bioanalytical Tools for the Characterization of Biologics and Biosimilars
LC–MS and CE–MS are the go-to techniques for characterizing biologics, but often help is needed from a range of other methods.
Strategies for Rapid Chiral HPLC Method Development for Pharmaceutical Analysis
Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes.
High Throughput Microchromatography
The growing importance of biotherapeutics to the pharmaceutical industry has created an increasing demand for protein analysis techniques with high precision, high sensitivity and high throughput.
Using Longer Aeris PEPTIDE Core-Shell HPLC/UHPLC Columns for Improved Peptide Mapping
Phenomenex Application Note
Light Scattering for the Masses Liposome Characterization by FFF-MALS-QELS
Wyatt Application Note
LC–MS-MS Method for the Determination of Enalapril and Enalaprilat from Human Plasma Using SOLA
Thermo Scientific Application Note
Method for the Determination of Beta Blockers from Urine Using SOLA CX
Simultaneous Determination of Amlodipine and Atorvastatin in Tablet Formulations and Plasma using Capillary Electrophoresis
Capillary electrophoresis (CE) with a UV photo-diode array (DAD) detector was used in a new method to detect the assay of amlodipine besylate (AML) and atorvastatin (ATO) in pharmaceutical formulations and human plasma.
Liposome Characterizatio by FFF–MALS–QELS
Liposomes are made of lipid bilayers and are often used in drug delivery by encapsulating the core with therapeutic drugs. During liposome research, formulation, manufacturing, and quality control, it is of great importance to monitor liposome size and encapsulation.
LC–MS-MS Method for the Determination of Enalapril and Enalaprilat fro Human Plasma Using SOLA
A liquid chromatography tandem mass spectrometry method for enalapril and enalaprilat from human plasma has been developed using Thermo Scientific SOLA cartridges. Sample preparation is fast, efficient, and reproducible giving excellent recovery levels for each compound.
New Generation Monolithic Silica Columns for Fast, High Resolution Drug Separations without High Pressures
Using a novel new-design monolithic silica column (Chromolith? HighResolution RP-18e), fast, high resolution separations were achieved for various drug mixtures without the high pressures characteristic of modern particulate technology.
New HPLC/UHPLC Assay Methods for Impurities in Tetracycline
Tetracycline (TC), a common antibiotic used to treat urinary tract infections, acne, gonorrhea, and other conditions, yields a toxic degradation product, 4-epianhydrotetracycline (EATC). General Chapter 226 of the U.S. Pharmacopeia and National Formulary (USP-NF), referred to by monographs for epitetracycline and drug products containing tetracycline hydrochloride (TC-HCl), prescribes an antiquated assay for EATC impurity in TC.
Analytical Tools for Enabling Process Analytical Technology (PAT) Applications in Biotechnology
For PAT, you need to choose the right analytical methods. Here's how.
Providing a Universal, One-step Alternative to Liquid-Liquid Extraction in Bioanalysis
Clean-up of Plasma and Serum Protein Digests for Protein Bioanalysis
Current Applications of UHPLC in Biotechnology Part II: Proteins and Glycans
A discussion of how UHPLC is used to conduct intact protein–antibody analysis and glycoprofiling to characterize biopharmaceutical drugs
Drug Discovery Advances Inextricably Linked to Specialty Gases
The development and commercialisation of new medical drugs is a complex and costly process, but increasing pressure is being placed on drug companies to accelerate the timeline from discovery of new drugs, through to clinical trials and then to their release onto the market. The pharmaceutical industry continues to demand ever more advanced products aimed at improving health and the quality of modern-day life.
Perfecting Processes in Drug Discovery
Janet Kelsey of The Column spoke to Frédéric Cheviron, Sales & Marketing Manager for Chiral Technologies Europe, about the technology they use in drug development and how companies can improve their method development.
Reliable Measurement of Silanol Suppression Potency in Alkyl-bonded Stationary Phases
The design of strategies to reduce the activity of residual silanols in conventional alkyl-bonded columns is still one of the main challenges in the current separation of basic compounds by reversed-phase liquid chromatography.
A Quality by Design (QbD) Based Method Development for the Determination of Impurities in a Peroxide Degraded Sample of Ziprasidone
Significant Costs Savings Achieved Through the Development of a New Analytical Method for Residual API Analysis with a Kinetex 1.7 µm Core-Shell UHPLC Column
Validation of a Method for the Separation of Ziprasidone and its Degradants Using Empower 2 with Method Validation Manager
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