Pharmaceutical Analysis

This month we interview Shijia Tang, principal scientist at Genentech, South San Francisco, CA, USA, about her innovative research focusing on the analysis of polymers and nanomaterials used in pharmaceutical analysis. Shijia decribes the benefits of an innovative in-line mixing modulation method for 2D-LC she developed for polymer and oligonucleotide analysis. The advantages of SEC–MALS to explore aggregation mechanisms for therapeutic constrained peptides and mRNA-lipid nanoparticles and their aggregates are also discussed.

Webinar Date/Time: Thu, Jan 25, 2024 2:00 PM EST

In this LCGC Blog, Muhammad Farooq shares some tips for entering different careers within the analytical chemistry industry.

In this study, an efficient technique is described for extracting and quantifying barbiturates in serum samples, combining ultrasound and surfactant-assisted dispersive liquid–liquid microextraction (dLLME) with poly(ethylene oxide)-mediated stacking in capillary electrophoresis.

Scientists from Egypt have developed a green reversed-phase high-performance liquid chromatography (RP-HPLC) method to determine the amounts of methionine and paracetamol in different mixtures.

Webinar Date/Time: Thu, Nov 30, 2023 2:00 PM EST

Webinar Date/Time: Thursday, December 7, 2023 at 9am EST | 2pm GMT | 3pm CET Thursday, December 7, 2023 at 1pm EST | 12pm CST | 10am PST

To better understand the purity of therapeutic peptides, scientists from Germany, studied the effects supercritical fluid chromatography (SFC) could have during the analysis.

A team of scientists from Taizhou, China have developed a means of studying the medical effects of Qiangxin Lishui Prescription (QLP).

Webinar Date/Time: Wed, Nov 15, 2023 11:00 AM EST 3:00 PM GMT | 4:00 PM BST

Webinar Date/Time: Thu, Jan 11, 2024 11:00 AM EST

Webinar Date/Time: Wed, Nov 8, 2023 11:00 AM EST

Webinar Date/Time: Wednesday, October 18th, 2023 12:30 pm BST 7:30 am EDT 13:30 pm CEST Thursday, October 19th, 2023 12:30pm BST | 7:30am EDT | 13:30pm CEST

Webinar Date/Time: Airing 1: Tuesday October 10, 2023 at 9am EDT | 8am CDT | 6am PDT Airing 2: Tuesday October 10, 2023 at 1pm EDT | 12pm CDT | 10am PDT

Scientists from the National Institute of Pharmaceutical Education and Research (NIPER) in India used a variety of techniques to characterize erdafitinib and its various products.

Webinar Date/Time: Thu, Sep 28, 2023 11:00 AM EDT

The 27th International Symposium on Separation Sciences (ISSS 2023) will be held 24–27 September 2023 in Cluj-Napoca, Romania. Here’s a sneak preview of what attendees can look forwards to.

As part of the upcoming Recent Advances in Gas Chromatography meeting, Nicholas Morley will look at how two-dimensional gas chromatography-time-of-flight-mass spectrometry analyzes pharmaceutical packaging.

Researchers have developed a polybutylene terephthalate-based stationary phase for ion-pair-free reversed-phase liquid chromatography.

New research using matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has revealed the distinct distributions of acetaminophen and its metabolite in the kidneys at an unprecedented resolution of 10 μm. The study, conducted by Mitsutoshi Setou and his team from Hamamatsu University School of Medicine in Japan, provides valuable insights into drug distribution and metabolism, enhancing our understanding of the pharmacokinetics and potential nephrotoxicity of acetaminophen.

Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.

This blog addresses the essential role software has in shaping the present and future of chromatography for the better.

Researchers have discovered that the combined use of deep eutectic solvents (DESs) and amino acid-based ionic liquids (AAILs) with cyclodextrin-based chiral selectors can significantly enhance the chiral separation of amphetamine derivatives.

Researchers have developed a novel algorithm that combines multivariate curve resolution-alternating least-square (MCR-ALS) and Bayesian inference techniques to estimate confidence intervals for the quantitation of coeluted peaks in liquid chromatography-photodiode array detection.

In this HPLC 2023 keynote lecture, Mario Thevis discusses how chromatographic–mass spectrometric approaches have led to important advancements in sports drug testing programmes.