Pharmaceutical Analysis

Webinar Date/Time: Wed, May 21, 2025 11:00 AM EDT

A research group has developed an improved workflow for constructing machine learning (ML) models in oligonucleotide separation.

Webinar Date/Time: Wed, Mar 19, 2025 11:00 AM EDT

Supercritical fluid chromatography (SFC) has been optimized for the analysis of 5-, 10-, 15-, and 18-mer oligonucleotides (ONs) and evaluated for its effectiveness in separating impurities from ONs.

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.

A team from the University of Geneva and Bayer AG present their findings on the on-off retention of oligonucleotides and the feasibility of separating them using very short columns.

A method to help detect genotoxic impurities (GTIs) using headspace gas chromatography (HS-GC) and deep eutectic solvents (DESs) has been developed.

At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.

Throughout 2024, the editors of LCGC International attended chromatography conferences across the globe. Below, you’ll find a sampling and overview of our conference coverage from the year.

An LC–HRMS approach for the simultaneous analysis of 15 N-nitrosamines in multiple APIs using a novel HILIC-based SPE clean-up step has been developed and tested.

Here is some of the most popular content posted on LCGC International this week.

In this article, we review some key considerations for chromatographic technique selection and method development across the full drug process—from early-stage active pharmaceutical ingredient (API) synthesis to routine commercial release activities.

Ronald Piervincenzi, chief executive officer of the United States Pharmacoepia, focused on how collaboration and component quality can improve worldwide pharmaceutical production standards during a lecture at the Eastern Analytical Symposium (EAS) last month.

Organic solvents are generally not compatible with ion chromatography (IC) systems. The approach presented here assists the use of organic solvents for sample preparation and provides a mechanism for the removal of the organic solvents from the chromatographic flow path.

Three analytical and two pre-treatment methods—gas chromatography–mass spectrometry (GC–MS), gas chromatography–tandem mass spectrometry (GC–MS/MS), and liquid chromatography–tandem mass spectrometry (LC–MS/MS) plus liquid-liquid extraction (LLE) and dried blood spot (DBS) —were compared for the quantitation and characterization of barbiturates.

Here is some of the most popular content posted on LCGC International this week.

Webinar Dates/Times: Friday, December 13, 2024 Morning Session: 12:30 pm GMT | 1:30 pm CET | 7:30 am EST Afternoon Session: 2:30 pm GMT | 3:30 pm CET | 9:30 am EST

Mithibai College of Arts scientists recently used liquid chromatography-tandem mass spectrometry (LC–MS/MS) for detecting nitrosamines in blood pressure medication.

Webinar Date/Time: Wed, Dec 11, 2024 11:00 AM EST

Scientists recently developed new GC/LC-Q-TOF/MS-based method for determining pesticides in Angelica sinensis, a traditional Chinese medicine.

LCGC International sat down with Faith Johnson of ECOLAB to discuss her career and work with the Females in Mass Spectrometry (FeMS) group.

The grant will be part of a new collaborative scientific initiative to address the need for standards that define the desired performance of lateral flow immunoassay test strips to detect illicit drugs in tablets and powders.

Nicholas Ingram of IQVIA Laboratories recently spoke with LCGC International about using high-resolution mass spectrometry (HRMS) to help monitor drug stability.

Webinar Date/Time: Thu, Nov 14, 2024 10:00 AM EST