Pharmaceutical Analysis

Discover a generic gas chromatography method for efficiently analyzing residual solvents in pharmaceuticals, ensuring compliance with regulatory standards.

Here is some of the most-read content posted on LCGC International this week.

Here is some of the most-read content posted on LCGC International this week.

Jon Bardsley of Thermo Fisher offers his perspective regarding the recent advances in PFAS detection in pharmaceutical manufacturing through the utilization of liquid chromatography-mass spectrometry (LC-MS), and factors that should be considered in achieving even greater advances.

Webinar Date/Time: Thu, Jun 26, 2025 11:00 AM EDT

Jon Bardsley of Thermo Fisher offers his perspective regarding the advancement of PFAS detection in pharmaceutical manufacturing with liquid chromatography-mass spectrometry (LC-MS), and the influence of regulations in the pharmaceutical and biopharmaceutical industries.

Webinar Date/Time: Mon, Jun 9, 2025 11:00 AM EDT

Webinar Date/Time: Tue, Jun 17, 2025 11:00 AM EDT

Isavuconazole, an antimycotic agent used to treat fungal infections, can typically be found during dried blood spot sampling. However, there are obstacles that keep it from being an ideal approach for properly determining the drug’s presence.

Michael Dong recently discussed sample preparation (SP) techniques for small-molecule drug substances and solid dosage forms.

Webinar Date/Time: Wednesday, May 28, and Thursday, May 29, 2025 Morning Sessions: 2:00pm BST | 9:00am EST | 3:00pm CEST Lunchtime Sessions: 5:30pm BST | 12:30pm EST | 6:30pm CEST Afternoon Sessions: 6:30pm BST | 1:30pm EST | 7:30pm CEST

During a recent LCGC International peer exchange discussion on nitrosamine analysis, our professional panelists discussed the complex issues surrounding the processes for detecting nitrosamines.

LCGC International spoke with Daniel Meston and Dwight Stoll from Gustavus Adolphus College in St. Peter, Minnesota, USA, about a project they worked on with Todd Maloney from Eli Lilly in Indianapolis, Indiana, USA, to investigate the optimal performance conditions of antisense oligonucleotides (ASOs) when using hydrophilic interaction liquid chromatography (HILIC).

This article discusses several practical examples using bioinert columns, demonstrating their ability to deliver reliable, high-resolution results with precision and reproducibility.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.

Webinar Date/Time: Wed, Apr 16, 2025 11:00 AM EDT

Webinar Date/Time: Wed, May 21, 2025 11:00 AM EDT

A research group has developed an improved workflow for constructing machine learning (ML) models in oligonucleotide separation.

Webinar Date/Time: Wed, Mar 19, 2025 11:00 AM EDT

Supercritical fluid chromatography (SFC) has been optimized for the analysis of 5-, 10-, 15-, and 18-mer oligonucleotides (ONs) and evaluated for its effectiveness in separating impurities from ONs.

A QuEChERS sample preparation technique coupled with a UHPLC–MS/MS method was developed to determine 19 veterinary drug residues in foods of animal origin.

A new method has been created for determining N-nitrosamines (NAs) in pharmaceutical preparations using liquid chromatography with tandem mass spectrometry.

A team from the University of Geneva and Bayer AG present their findings on the on-off retention of oligonucleotides and the feasibility of separating them using very short columns.

A method to help detect genotoxic impurities (GTIs) using headspace gas chromatography (HS-GC) and deep eutectic solvents (DESs) has been developed.

At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.