Application Notes: General

To help customers leverage digital transformation and prepare for the lab of the future, LabVantage Solutions has devised a five-step process for successfully implementing and profiting from AI in the lab and across the enterprise.

Using a single GC-MS/MS configuration to monitor environmental contaminants including pesticides, micropollutants and POPS.

Ensuring safe drinking water utilizing GCMS couple with purge and trap

Hear how Eurofins GfA Lab Service utilize Orbitrap Exploris GC for food analysis

A subscription-based Laboratory Information Management System (LIMS), hosted in the cloud and delivered via the Internet, is a secure, scalable, and cost-effective alternative to traditional software licensing, installation, maintenance, validation, and management. Here’s what you need to know to determine if the software-as-a-service (SaaS) delivery model for a LIMS is right for your organization.

Advanced analytics in the lab can extract enormous value from an existing asset – your LIMS data. Discover how a lab-specific, LIMS-ready advanced analytics solution can solve the multi-challenges of data access, visibility, volume, and speed to yield complete data views and endless insights.

The utility of the Thermo Scientific™ TRACE™ 1610 GC system and the Thermo Scientific™ TSQ™ 9610 triple quadrupole GC-MS/MS for the analysis of ethylene oxide and 2-chloroethanol residues in food

Drive growth by establishing integrated, AI-fueled lab systems and a data-driven corporate culture that’s ready and resilient, no matter what business challenges emerge tomorrow. Evolving to a Lab of the Future takes the right technologies, systems, and expert guidance.

This high-throughput proteome profiling approach provides deeper proteome coverage with preserved biological information. The ENRICH-iST technology enables the analysis of previously undetected low- abundance proteins, facilitating the discovery of additional potential biomarkers.

Designed initially to expedite proteomic sample preparation, the BeatBox now emerges as a pivotal instrument for metabolomic and lipidomic sample preparation. Its highly efficient extraction of polar metabolites and non-polar lipids from tissues aids the processing of limited specimens, ideal for targeted MS approaches.

The first reported combination of microdroplet reactions with ECD fragmentation offers a quicker way to analyze monoclonal antibodies for disease treatments. Thomas Walker from Agilent Technologies and co-workers demonstrate the use of an Agilent Jet Stream electrospray ionization source to facilitate in-spray chemical reduction and protease digestion of monoclonal antibodies. Downstream fragmentation of the microdroplet reaction products with ECD provided rapid characterization of intact antibodies in minutes. Efficient ECD fragmentation yielded rich sequence information including evidence of disulfide bond connectivity and confirmation of key sequences called complementary determining regions. These results highlight this method’s potential for fast and cost-effective antibody characterization with minimal sample preparation.

ENRICH-iST effectively addresses the challenge of high diluted protein content and high dynamic abundance range, which is typical for CSF samples. By improving the detection of low-abundance proteins, ENRICH-iST is a powerful tool for advancing the discovery of new protein biomarkers in CSF proteomic studies.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

The Charge Variant Analysis (CVA) kit offers superior performance over our first-generation Intact Antibodies kit. With the CVA kit, users can expect greater peak resolution and the ability to properly analyze proteins in their fully native states.

The traditional method for HPLC gradient validation uses a UV detector which has documented limitations. An improved approach using non-invasive flowmeters is described.

This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.

Charge heterogeneity is present in most biopharmaceutical protein products. During the manufacturing process, charge heterogeneity of the protein therapeutics can occur due to enzymatic cleavage and chemical post-translational modifications (PTM). For therapeutics like ADCs, not only the antibody contributes to the heterogeneity but also the linker and payload, which add even more complexity to the charge variant profiles. Characterizing the charge heterogeneity of ADCs is essential for critical quality attribute (CQA) assessment to ensure drug safety, efficacy, and potency.

Despite the utility of the essential oil mixture, it has been shown that allergies can arise from some of the individual components.

Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.

For many years, Solid Phase Extraction (SPE) has been performed using plates and cartridges packed with a bed of loose media. Extracting samples of interest while removing contamination from samples presented to the chromatography system results in lower costs associated with detector maintenance and extends column lifespan. Cleaner samples also improve specificity in analysis and increase sensitivity. Traditional products, however, have inherent limitations in reproducibility of flow and recovery. The innovative composite technology found in the Microlute® range greatly improves flow consistency providing a step change in the reproducibility of processing and analyte recover.

Chromium can pose as a beneficial element or a poison, therefore it is imperative to identify contaminated waters, especially drinking water.

The Microlute® CSi products use a novel composite technology which uses a blend of porous plastic and chromatographic SPE resin. This technology has been designed to eliminate issues caused by inherent issues and inconsistent packing of loose packed SPE plates. The data in this application note compares SPE results from a C18 10 mg loose packed plate with a C18 10 mg composite plate (Microlute® CSi) which were both created using the same batch of C18 resin.

GRPC peptides are found in the entire body. Isolation of seven classic GRPC peptides initiating in the GI tract could implicate disease.

The isolation and identification of 5 common psychedelic compounds was performed using the alkaline ion-pairing agent hexylamine to facilitate excellent resolution.

This poster describes GenNext’s first-in-class instrument for fully automated protein footprinting that delivers highly precise and accurate quantification for numerous higher order structure (HOS) mapping experiments.

Restek is a global leader in PFAS analysis with advanced sample prep and analytical techniques. We’ve gathered feedback from labs around the world to offer the latest insights, applications, and tailored solutions on this resource page. Count on Restek as your partner in PFAS analysis. Have questions?