Application Notes: General

Reduce sample prep time by filtering your water samples in an auto sampler ready Thomson filter vial. These vials help reduce sample prep time and reduced materials needed.

This application note describes the extraction of thirty-one PFAS compounds from human serum using Biotage® ISOLUTE® PLD+ for PFAS prior to UHPLC-MS/MS analysis.

Speed up your sample preparation time by removing syringe filtration or centrifugation steps. Thomson filter vials allow you to filter your ground water samples in autosampler-ready vials.

Replace time consuming and material heavy syringe filtration steps in EPA Method 539 with Thomson filter vials quick 5s filtration in a ready-to-analyze autosampler vial. Thomson filter vials replace the syringe filter, syringe, and auto sampler vials with one filter vial that goes right on your instrument for analysis.

Lipid oxidation generates off-odors in food, edible oils, and fats. DHS or Thermal Extraction-GC-MS/O using Sensory Directed Analysis quickly identifies off-odors.

This comprehensive peer-reviewed set of more than 600 definitions covers topics of interest for the biopharmaceutical and gene therapy subjects of genetics, therapeutics, drug development, clinical medicine, and the analytical science tools used for characterization of drugs. This glossary serves as a helpful reference to both novice and advanced scientists, engineers, and business executives involved with biopharmaceuticals and gene therapy technologies. Online sources of information for topics covered in this guide are also included for additional insights.

In this article, the results of a DIMS air monitoring campaign in Auckland, New Zealand, are described. Real-time SIFT–MS measurements were obtained at three sites over a period of several weeks. At each site, SIFT–MS provided effective on-site analysis to sub-ppbV levels with better than 1-min time resolution.

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying. We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real time.

This publication reviews VOC pollutant monitoring applications of SIFT-MS in South Korea. SIFT-MS has been applied to emission source characterization, fenceline monitoring, ambient monitoring, pollution mapping, and incident response (including the use of drone-based sampling) for hazardous air pollutants (HAPs), odor nuisance species, and compounds that have high ozone formation potential (OFP) and/or contribute to secondary aerosol (SOA) formation.

Discover the outstanding separation of three plasmid DNA isoforms, linear, open circular and supercoiled in HIC mode using YMC’s BioPro HIC BF column.

Agilent workflow solutions, designed for the food and beverages industry, serve as a comprehensive resource for testing alternative proteins. This compendium provides 15 applications across various domains, such as taste and flavor, nutrition, food quality, and food safety leveraging advanced analytical techniques like ICP-MS, LC/MS, GC/MS, and HPLC.

Headspace-SIFT-MS provides rapid and sensitive analysis of benzene and other contaminants in commercial products. It enables the daily screening of hundreds of samples.

Read about how the University of York used mobile SIFT- MS to experimentally verify that motor vehicle screen wash is a significant unreported source of VOC emissions

SIFT-MS has unique advantages in air quality measurement applications. It enables environmental incidents to be detected and remedied before they escalate.

This application note demonstrates that automated headspace-SIFT-MS analysis has the potential to screen larger sample numbers for the volatile MOH fraction, providing a rapid indication of packaging material contamination. As benzene has also recently been found to be problematic in commercial products, Headspace-SIFT-MS can screen over 220 samples per day for volatile MOSH and MOAH compounds – nearly seven-fold more samples than the routine liquid and gas chromatography method.

Quantitative analysis of volatile nitrosamine impurities in drug products is simplified using SIFT-MS and has a 3X throughput advantage over chromatographic methods.

In this study, Syft Tracer analyzed the same samples in 9 hours that took 5 chromatographic systems 24 hours to complete and still had capacity to spare.

Real time monitoring of flow using a non-invasive flowmeter offers a new diagnostic tool for measuring performance & troubleshooting problems with pumps serving HPLC systems

In this short note, we will consider the selection of LC procedures to isolate ezetimibe from several of its degradants and show how data automation improves the process.

This innovative AEX method replaces toxic TMAC with non-toxic choline-Cl, ensuring safety and efficiency in AAV capsid analysis, applicable across multiple AAV serotypes.

Determine the molecular weight of low abundant species with confident with the highly sensitive DAWN MALS detector and improved peak separation with Waters BEH Column.

Explore SEC-MALS-RI multi-attribute quantification of antibodies, biosimilars, and AAVs.

Explore the optimization of AAV separation and the combined intrinsic fluorescence detection with SEC-MALS for low-concentration measurement.

This application note shows the performance of the KNAUER AZURA UHPLC system to speed up your method and increase throughput preserving resolution.

The use of method development software with analytical quality by design (AQbD) approaches can produce robust methods but are limited by both access to the software and user proficiency. Other approaches require more manual intervention to select the correct conditions, interpret the results, and make decisions based on the data. This application note, we explore using a systematic screening protocol to develop a method for the analysis of a mixture of nine structurally similar spice cannabinoids.

Advances in LC-MS/MS technology have allowed for a more comprehensive and rapid multi-class drug method to be developed. This highlighted method allows for the use of a protein precipitation and sample filtration with Thomson eXtreme|Filter Vials® followed by a rapid 8 min/sample run time, thus allowing for the reduction in multiple LC-MS/MS methods being run in the laboratory, freeing up valuable instrument time.

Triazine herbicides are commonly used in crop management to remove invasive plant species. These herbicides disrupt the photosynthesis cycle, leading to plant death and can contaminate soil and groundwater if used in high enough concentrations and for long enough duration. As such, the monitoring of these herbicides is important to minimize and monitor contamination. The app note outlines using a systematic screening protocol to develop a method for the analysis of a mixture of seven structurally similar triazine herbicides.

Often, method development activities are performed “on the fly” with tight timelines to achieve the goal of developing robust methods quickly. Unfortunately, the approach to method development is an often-overlooked aspect of the process. In this app note, we talk about employing a systematic screening protocol, which utilizes a structured decision-making process, alleviates the pressure on the analyst to select the best set of conditions, and streamlines the method development process.