Application Notes: General

Experience high recoveries from the first injection! YMC Accura BioPro IEX SF columns provide excellent peak shapes for the ion-exchange analysis of mAbs.

The optimized LC-MS/MS method covering 388 signaling lipids shows that the bioinert coated YMC Accura Triart C18 column combines high sensitivity with high resolution.

In this application note, the charge variant characterisation of IgG4-based mAbs was performed using a BioPro IEX QF anion exchange column coupled to an MS detector.

The non-targeted screening of polar metabolites in human plasma with high sensitivity is achieved using a bioinert YMC Accura Triart Diol HILIC column.

The analysis of human plasma samples using a bioinert coated YMC Accura Triart C8 column demonstrates that real-life lipidomic analysis in under 10 minutes is possible.

This non-IP-RP method, using ammonium bicarbonate as mobile phase additive, is highly sensitive and suitable for the bioanalysis of therapeutic oligonucleotides.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

This application note demonstrates the analysis of 9 halogenated acetic acids, which are regulated by the EPA and the European Union, using ICPMS/MS for detection.

The Axcend Focus LC®, a portable capillary liquid chromatograph, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for analysis of pharmaceutical drugs.

Compact HPLC Specification

Axcend’s revolutionary line-up of eco-friendly, compact and portable HPLC instruments and accessories are engineered to deliver consistent, high-quality performance, ensuring precise and dependable analytical results. Compact and portable, the Axcend Focus LC deliver HPLC Anywhere™.

A demonstration of emptying a waste container of a compact and portable LC system.

The Axcend Focus LC® stands out as an eco-friendly high-performance liquid chromatograph (HPLC) due to its innovative design and sustainable features. This compact system uses significantly less solvent, consuming under 10 mL per week, and produces roughly the same amount of waste. Additionally, its energy consumption is a fraction of that of larger, bench-top LCs. By minimizing solvent use and waste production, the Axcend Focus LC not only reduces operational costs but also aligns with green analytical chemistry principles, making it an environmentally responsible choice for laboratories

Hear how Eurofins SOFIA GmbH successfully implemented the TSQ 9610 GC-MS/MS into their workflow for trac contaminant analysis and increased higher sample throughput using the combination of instrumentations and software.

Utilizing GC-MS/MS to quantify low levels of PBDEs in matrix samples. Including an assessment of linearity and instrument detection limits (IDLs) for all compounds as well as an extended robustness study over n=100 injections of matrix samples to assess the reproducibility of the detection of trace levels of PDBEs.

In this study, the suitability of the TSQ 9610 triple quadrupole GC-MS/MS system was assessed for the analysis of more than 200 pesticides in black tea at trace concentrations supplemented with SPE cleanup. The linearity, accuracy, precision, limit of quantitation, and injection reproducibility of 20 selected analytes representative of the different pesticide classes in black tea matrix are demonstrated.

The benefits of the Thermo Scientific™ Orbitrap Exploris™ GC mass spectrometer system for the analysis of trace level contaminants, such as pesticides, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and brominated flame retardants (BFRs) are showcased.

Abacavir and Lamivudine in combination are used with other medications to treat Human Immunodeficiency Virus (HIV) infection. In this technical note, we report the separation of Lamivudine from its related chiral and diastereomeric impurities in Abacavir and Lamivudine tablets per the USP monograph. The allowable adjustments pertaining to gradient separations are highlighted together with the necessary calculations that are required for the adjusted method conditions to remain compliant with the original monograph.

The necessity to analyse drug products for nitrosamines and NDSRIs (Nitrosamine Drug Substance Related Impurities) is well documented. In this document we provide an overview of 7 of our most recent applications in this area, together with links to the relevant technical notes.

This applications notebook provides background information on GLP-1 analogues, together with information on the columns suitable for their purification and analysis. Finally it provides a range of reversed phase, size exclusion and preparative applications for a number of GLP-1 analogues.

LC-MS/MS method for low level quantitation of seven PFAS listed in the National Academies of Science and Engineering recommendations for clinical research.

Combining a Phenomenex Gemini C18 LC column High Resolution, high accuracy mass spectrometry was used to resolve interferences observed during analysis of PFAS in plasma and serum.

This white paper explores L/dp ratio for pharmacopeia allowable adjustments. It considers efficiency, explaining why L/dp ratio can be used as a proxy for efficiency, and illustrates the allowable adjustments through reviewing at a selection of different monographs.

Comparison of blood collected using volumetric absorptive microsampling (VAMS) and serum for LC-MS/MS for analysis of a comprehensive PFAS panel

This white paper provides an in depth consideration of the new European Pharmacopeia monograph for the analysis of chlorhexidine and it’s related impurities. The white paper considers both column batch variation and system dwell volume.

A simplified SPE procedure using UCT’s HL DVB polymeric sorbent for the analysis of 64 Pharmaceuticals and Personal Care Products (PPCPs) in water according to EPA Method 16

Tire wear particles left on roads can cause marine and air pollution. Py-GC-MS identifies and quantifies microplastics present in air, sand, soil, and other materials.