Application Notes: General

Automated wine aroma profiling using sorptive extraction and GCxGC: This study uses headspace sorptive extraction with GCxGC–TOF MS/SCD, enhanced by Tandem Ionisation

Digital transformation is about more than moving from paper to glass. It’s about the way that enterprises use technology and data to build a business ecosystem, thereby reducing risk, accelerating innovation, and driving growth.

Analysis of proficiency test (PT) samples to demonstrate the benefits of combining GC-MS/MS and LC-MS/MS with the innovative Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS).

Protecting the environment with the analysis of PFAS in air

Food packaging screening using the Orbitrap Exploris GC 240 mass spectrometer and Compound Discoverer software enable sensitive compound detection and identification.

Detecting and identifying untargeted environmental contaminants in a complex matrix

Analyzing PAHs in accordance with U.S. EPA 8270E utilizing Hydrogen as a carrier gas.

To help customers leverage digital transformation and prepare for the lab of the future, LabVantage Solutions has devised a five-step process for successfully implementing and profiting from AI in the lab and across the enterprise.

Using a single GC-MS/MS configuration to monitor environmental contaminants including pesticides, micropollutants and POPS.

Ensuring safe drinking water utilizing GCMS couple with purge and trap

Hear how Eurofins GfA Lab Service utilize Orbitrap Exploris GC for food analysis

A subscription-based Laboratory Information Management System (LIMS), hosted in the cloud and delivered via the Internet, is a secure, scalable, and cost-effective alternative to traditional software licensing, installation, maintenance, validation, and management. Here’s what you need to know to determine if the software-as-a-service (SaaS) delivery model for a LIMS is right for your organization.

Advanced analytics in the lab can extract enormous value from an existing asset – your LIMS data. Discover how a lab-specific, LIMS-ready advanced analytics solution can solve the multi-challenges of data access, visibility, volume, and speed to yield complete data views and endless insights.

The utility of the Thermo Scientific™ TRACE™ 1610 GC system and the Thermo Scientific™ TSQ™ 9610 triple quadrupole GC-MS/MS for the analysis of ethylene oxide and 2-chloroethanol residues in food

Drive growth by establishing integrated, AI-fueled lab systems and a data-driven corporate culture that’s ready and resilient, no matter what business challenges emerge tomorrow. Evolving to a Lab of the Future takes the right technologies, systems, and expert guidance.

This high-throughput proteome profiling approach provides deeper proteome coverage with preserved biological information. The ENRICH-iST technology enables the analysis of previously undetected low- abundance proteins, facilitating the discovery of additional potential biomarkers.

Labile post-translational modifications are better preserved using ECD than conventional MS fragmentation techniques such as collision-induced dissociation (CID). Common modifications, such as glycosylation and phosphorylation, can impact the safety, efficacy, and binding activity of monoclonal antibodies but are challenging to identify. Stephen Sciuto from Agilent Technologies and colleagues analyzed tryptic digests of NIST mAb and Infliximab using an 6545XT Q-TOF mass spectrometer in ExD or CID mode. ECD provided higher sequence coverage than CID, reaching 100% for glycosylated peptides in Infliximab. The ability to pinpoint glycosylation sites using fragment ions demonstrates the power of ECD for characterizing glycopeptides.

Designed initially to expedite proteomic sample preparation, the BeatBox now emerges as a pivotal instrument for metabolomic and lipidomic sample preparation. Its highly efficient extraction of polar metabolites and non-polar lipids from tissues aids the processing of limited specimens, ideal for targeted MS approaches.

The first reported combination of microdroplet reactions with ECD fragmentation offers a quicker way to analyze monoclonal antibodies for disease treatments. Thomas Walker from Agilent Technologies and co-workers demonstrate the use of an Agilent Jet Stream electrospray ionization source to facilitate in-spray chemical reduction and protease digestion of monoclonal antibodies. Downstream fragmentation of the microdroplet reaction products with ECD provided rapid characterization of intact antibodies in minutes. Efficient ECD fragmentation yielded rich sequence information including evidence of disulfide bond connectivity and confirmation of key sequences called complementary determining regions. These results highlight this method’s potential for fast and cost-effective antibody characterization with minimal sample preparation.

ENRICH-iST effectively addresses the challenge of high diluted protein content and high dynamic abundance range, which is typical for CSF samples. By improving the detection of low-abundance proteins, ENRICH-iST is a powerful tool for advancing the discovery of new protein biomarkers in CSF proteomic studies.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

In this study, we present an ion-pairing-free method for AXPs analysis using microchip CE-MS. This fast, simple method achieves baseline resolution for Adenosine, AMP, ADP, and ATP. Excellent linearity and sensitivity are observed in human plasma.

The Charge Variant Analysis (CVA) kit offers superior performance over our first-generation Intact Antibodies kit. With the CVA kit, users can expect greater peak resolution and the ability to properly analyze proteins in their fully native states.