Application Notes: General

This article will discuss several aspects of working with high purity water in LC-MS analyses including quality and handling. Solutions will be proposed for optimal water purification based on the use of complementary purification technologies combined with application-specific final filtering, and finally, the importance of water purification system maintenance will be discussed.

This article will discuss several aspects of working with high purity water in LC-MS analyses including quality and handling. Solutions will be proposed for optimal water purification based on the use of complementary purification technologies combined with application-specific final filtering, and finally, the importance of water purification system maintenance will be discussed.

Improve efficiency and streamlining workflows for GC and LC labs with CDS software.

This application note demonstrates the potential of valorizing mother liquor using Centrifugal Partition Chromatography (CPC) to remediate minor cannabinoids.

This application note examines the USP acetaminophen impurities using an HPLC system and UPLC System. Improvements in sample throughput and solvent usage were realized by using newer technology.

In this application note the USP monograph method for naproxen sodium tablets was modernized and Analytical Method Greenness Scoring (AMGS) values were assigned to each system used. The use of newer technology including sub-2 µm columns provides not only improvements to throughput and solvent usage but also drastically improved AMGS values.

This application note examines the analysis of quetiapine fumarate using HPLC, UHPLC and UPLC Columns. Considerable improvements to run time and solvent usage were achieved by modernizing to UPLC Columns.

Microplastics in water are a major concern, found even in tap water and human bodies. Learn how Sartorius Arium® Pro VF series removes them effectively.

Achieving reliable trace perchlorate analysis proving difficult? Discover this powerful IC method for simple, ultra-low detection in water matrices.

This application note demonstrates the use of the Agilent 1260 Infinity II Hybrid Multisampler for the analysis of per- and polyfluorinated alkyl substances (PFAS). The Hybrid Multisampler in feed injection mode was used with optimized Feed Speed for the sample injection to trap and enrich the compounds on the column. This avoided peak broadening and breakthrough of the early-eluting polar PFAS compounds. The less polar PFAS compounds can be enriched for more sensitive quantification.

This overview of instruments and applications shows various solutions for purification, characterization and quality control which are indispensable for the development of oligonucleotide therapeutics.

Due to their ability to tackle targets that were considered “undruggable”, oligonucleotides represent a key cornerstone of the future of personalized medicine. This infographic presents the different types of therapeutic oligonucleotides and highlights some innovative solutions for their analysis.

The US EPA has released interim health advisory limits (HALs) of 4 and 20 pg/L in drinking water for the PFAS perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), respectively. This application note addresses PFAS testing at these challenging new levels in aqueous samples using optimized solid-phase sample extraction and LC/MS/MS analysis with an Agilent 1290 Infinity II liquid chromatography (LC) system coupled to an Agilent 6495C triple quadrupole (TQ) mass spectrometer.

Explore how an integrated, single platform imaged capillary isoelectric focusing (icIEF)-UV/MS workflow with the Intabio ZT system aims to tackle the challenge of charge heterogeneity profiling with a disruptive strategy that allows for separation, quantitation, and identification of individual charge variants to be achieved in minutes on a single platform.

Due to their ability to tackle targets that were considered undruggable, oligonucleotides represent a key cornerstone of the future of personalized medicine. This infographic presents the different types of therapeutic oligonucleotides and highlights some innovative solutions for their analysis.

Cell or microbiological media and buffer preparation involve dissolving precise amounts of various salts, nutrients, and buffering agents in ultrapure water, followed by pH adjustment to suit specific organism requirements.

Sample preparation tools such as pipettes and lab water systems are vital for nucleic acid techniques (NAT), where high quality, contamination-free reagents and precise volume measurements are essential for reproducibility and accuracy.

Discover essential sample preparation tools for quality control, method development, and analytical excellence in chromatography, spectrometry and elemental analysis.

Bioassay techniques are pivotal in quantifying and characterizing the effects of substances on biological systems. Utilized extensively in biotherapeutics, diagnostics, and environmental sciences, these assays range from ELISA for protein and antibody detection to flow cytometry for cell health analysis. Bio-layer interferometry and cell-based assays further elucidate drug-receptor interactions.

Characterizing the ratio of tumor-killing payload to cancer-binding antibody (DAR) is a critical quality attribute that helps determine the potential potency of a given antibody-drug conjugate (ADC) candidate. The TSKgel® HIC-ADC Butyl column, developed by Tosoh Bioscience, enables improved HIC-based separations for quantifying the DAR of ADCs.

In this poster, we explore parameters that could impact data integrity with the analytes in EPA Method 1633, UCMR 5 and the EU Drinking Water Directive regulations.

Sartorius provides an extensive selection of lab essentials tailored for the initial stages of sample handling and preanalytical processes in quality assurance labs, catering to diverse characterization requirements. Our lineup includes accurate lab scales, high-purity water purification systems, superior filtering equipment, and comfortable pipettes and tips

Discover how the Brevis™ GC-2050 is Leading the Way in Compact Gas Chromatography

Measuring ultrashort-chain PFAS (C1-C4) in water is crucial due to their ubiquity and potential human exposure. Standard RPLC tests struggle with these compounds.

This application note discusses the latest development on high performance cation exchange bio-separation columns for determining charge variants in protein-based biotherapeutics, as well as the strategy on method development.

Download this infographic for a quick overview of Shimadzu’s LabSolutions Method Development (MD) software, an effective and automated software solution for U/HPLC method development that uses analytical quality by design (AQbD) principles in its workflow.