Application Notes: General

Discover essential sample preparation tools for quality control, method development, and analytical excellence in chromatography, spectrometry and elemental analysis.

Bioassay techniques are pivotal in quantifying and characterizing the effects of substances on biological systems. Utilized extensively in biotherapeutics, diagnostics, and environmental sciences, these assays range from ELISA for protein and antibody detection to flow cytometry for cell health analysis. Bio-layer interferometry and cell-based assays further elucidate drug-receptor interactions.

Characterizing the ratio of tumor-killing payload to cancer-binding antibody (DAR) is a critical quality attribute that helps determine the potential potency of a given antibody-drug conjugate (ADC) candidate. The TSKgel® HIC-ADC Butyl column, developed by Tosoh Bioscience, enables improved HIC-based separations for quantifying the DAR of ADCs.

In this poster, we explore parameters that could impact data integrity with the analytes in EPA Method 1633, UCMR 5 and the EU Drinking Water Directive regulations.

Sartorius provides an extensive selection of lab essentials tailored for the initial stages of sample handling and preanalytical processes in quality assurance labs, catering to diverse characterization requirements. Our lineup includes accurate lab scales, high-purity water purification systems, superior filtering equipment, and comfortable pipettes and tips

Discover how the Brevis™ GC-2050 is Leading the Way in Compact Gas Chromatography

Measuring ultrashort-chain PFAS (C1-C4) in water is crucial due to their ubiquity and potential human exposure. Standard RPLC tests struggle with these compounds.

This application note discusses the latest development on high performance cation exchange bio-separation columns for determining charge variants in protein-based biotherapeutics, as well as the strategy on method development.

VOCs collected from air onto a sorbent packed tube are released by thermal desorption and focused for GC-MS determination using the novel cryogen free dynamic focusing

Achieve exceptional peak shapes in LC-MS analysis of the challenging phospholipids LPC and PC with the bioinert coated YMC Accura Triart C18 columns.

Explore the game-changing benefits of the bioinert YMC Accura Triart C18 columns for phosphorylated peptide analysis to achieve reproducible results.

The non-targeted screening of polar metabolites in human plasma with high sensitivity is achieved using a bioinert YMC Accura Triart Diol HILIC column.

The analysis of human plasma samples using a bioinert coated YMC Accura Triart C8 column demonstrates that real-life lipidomic analysis in under 10 minutes is possible.

In this application note the chelating agents 8-hydroxyquinoline and hinokitiol were analyzed using a bioinert coated YMC-Accura Triart C18 column.

Experience high recoveries from the first injection! YMC Accura BioPro IEX SF columns provide excellent peak shapes for the ion-exchange analysis of mAbs.

The analysis of 3 different RNA and DNA oligonucleotide mixtures demonstrates the supremacy of the bioinert coated YMC Accura Triart Diol-HILIC columns.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

A new technical study demonstrates the utility of a non-invasive liquid flowmeter for validating the performance of HPLC systems across a range of 9 different solvents.

We assess the benefits of the Alliance iS Bio HPLC System by migrating and modernizing a compendial SEC method outlined in the USP General Chapter <129>.

Combining the gradient method adjustments with the Alliance™ iS HPLC System to achieve both column dimension and system modernization for the USP monograph separation of abacavir sulfate

Fast separation (within 8 minutes) and quantification of lactose and its isomers in commercial lactose-free products using HPAEC-PAD.

Discover how to automatically manage all the purification steps involved in process scale chromatography including generation of the elution mobile phase, the injection of samples, the detection of molecules, and the collection of fractions.

Discover the 7 factors you should consider for your ideal HPLC Oligo purification setup.

Separation up to DP40 within 25 minutes run time, enabling fast profiling of oligo- and polysaccharides in honey samples using the SweetSep™ AEX200 HPAEC column.

Discover how Gilson has helped the Institute for Research and Innovation in Biomedicine (IRIB) overcome challenges in peptide purification with our high-performance liquid chromatography (HPLC) solutions.

Fast and sensitive method within 8 min for the quantification of sucralose in food and beverage samples using HPAEC-PAD with SweetSep™ column.

The ALEXYS™ Carbohydrate Analyzer with the SweetSep™ AEX200 column allows for sensitive HPAEC-PAD analysis of carbohydrates in various food and dairy products.