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Researchers from the University of Rome have developed a strategy for the identification of underivatized short peptides in urine using graphitized carbon black (GCB) solid-phase extraction (SPE) and liquid chromatography–mass spectrometry (LC–MS).

The first Analytica Lab Africa took place this July at the Gallagher Convention Center in Johannesburg with 148 exhibitors from 15 countries presenting their products and solutions for the African market.

Click the title above to open The Column September 2019 North American issue, Volume 15, Number 9, in an interactive PDF format.

Click the title above to open The Column September 2019 Europe & Asia issue, Volume 15, Number 9, in an interactive PDF format.

In an effort to better understand the current application potential of microscale liquid chromatography (micro-LC), I picked up a few recent review articles from the literature. What one immediately appreciates from glancing through the literature for such information, is that there are a lot of different configurations and alternative formats, which can be placed under the micro-LC umbrella.

Click the title above to open the LCGC Asia Pacific August/September 2019 regular issue, Vol 22, No 3, in an interactive PDF format.

Click the title above to open the LCGC North America September 2019 issue, Volume 37, Number 9, in an interactive PDF format.

Glycosylation is the most common monoclonal antibody (mAb) posttranslational modification. What is essential to know about it?

Are EU GMP Chapter 4 and USP Chapter on Good Documentation Guidelines similar or complementary? Should we consider any other sources of advice?

In on-site environmental applications, representative sampling and proper replication are essential. For these reasons, recent work in thin-film solidphase microextraction has focused on the development of unique holders and customized samplers that are tailored for distinct sampling environments. Here, we explore the latest developments.

The sample solvent can have a big impact on peak shape in both reversed-phase and hydrophilic interaction liquid chromatography (HILIC) separations, especially when large volumes are injected. Diluting the sample with weak solvent can be an effective solution to mitigate this problem, but we have to be careful to not lose analytes of interest to precipitation or phase separation.

Most manufacturers ship gas chromatographs with a small collection of consumable parts and accessories, such as extra ferrules, inlet liners, or septa, and a few instrument-specific tools. In earlier times, some convenience items might have been included as well, like a bubble flow meter or a small set of tools, but now it’s rare to find such things in the shipping boxes. This edition of “GC Connections” lists a number of essential items that should be on hand in every gas chromatography (GC) laboratory, their function, and how to use them effectively.

The 9th International Symposium on Recent Advances in Food Analysis (RAFA 2019) will take place in Prague, Czech Republic, on 5–8 November 2019.

Our recent discussion on the use of hydrogen as a carrier for gas chromatography applications elicited many questions and comments, however one common question was “what are the considerations for using hydrogen carrier with MS detectors?”

Click the title above to open The Column August 2019 Europe & Asia issue, Volume 15, Number 8, in an interactive PDF format.

Click the title above to open The Column August 2019 North American issue, Volume 15, Number 8, in an interactive PDF format.

Recently, I was honored to attend the 2019 Shimadzu Global Innovation Summit, hosted by Shimadzu Corporation in Kyoto, Japan. The focus of this meeting was to highlight innovation at the interface between analytical chemistry and medicine.

Incognito is thinking long-term. Is there scope for hope in the future?

Organized by The Chromatographic Society and the Separation Science Group of the Royal Society of Chemistry’s (RSC) analytical division, the Emerging Separation Technologies meeting was held on the 28 March 2019 at the RSC’s central London headquarters in Burlington House.

Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to determine the molar mass distribution of synthetic macromolecules. However, some kinds of polymers (for example, polyolefins) are often only soluble in special solvents and require high temperatures to be used during the analysis to keep the sample completely dissolved. Therefore, for the analysis of these polymers, dedicated high temperature GPC systems are used. This article will discuss the pros and cons of both high temperature GPC/SEC and ambient GPC/SEC.

An excerpt from LCGC’s professional development platform, CHROMacademy.com, on the importance of tuning and calibration in liquid chromatography–mass spectrometry (LC–MS).

The Community for the Analytical Measurement Science (CAMS) was officially launched on 27 June at the Royal Society of Chemistry, Burlington House, London, UK.

A new method for the accurate molecular weight determination of the complex polysaccharides chitosans has been developed using asymmetric AF4 coupled with MALS and differential RI detectors.

Shimadzu has received two Red Dot Design Awards in the product design category for its new Nexera UHPLC series LC-40 and UV-1900 UV–vis spectrophotometer.

Researchers from the University of Huddersfield present new data and announce further studies which show great potential for the development of a for a noninvasive multiple sclerosis diagnostic tool which uses GC–MS.

Click the title above to open the LCGC North America August 2019 issue, Volume 37, Number 8, in an interactive PDF format.