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To better understand modern sample preparation techniques-such as ultrasound-assisted extraction, microwave-assisted extraction, and pressurized solvent extraction-we should look at the lessons these methods took from Soxhlet extraction.

In LC–MS, the importance of tuning and calibrating the mass spectrometer cannot be overemphasized. There are six main aspects to address.

HILIC has rapidly evolved into a practical technique. For analyzing highly polar compounds, HILIC can be far more straightforward than GC or reversed-phase LC with derivatization, and can lead to a simpler final method with robustness comparable to that of reversed-phase LC.

Several regulatory data integrity guidance documents require that laboratories understand the data life cycle of their processes, but provide only vague definitions of what a data life cycle is. Here is a practical interpretation.

This instalment is the first of a series of four white papers on high performance liquid chromatography (HPLC) modules (pump, autosampler, UV detector, and chromatography data system) to be published in 2019. This instalment provides an overview for analytical-scale HPLC pumps, including their requirements, modern designs, operating principles, trends, and best practices for trouble-free operation.

The 12th Balaton Symposium on High‑Performance Separation Methods will be held 11–13 September 2019 in the Hotel Azúr in Siófok, Hungary.

As I receive reports from clients in Europe and the United States that helium prices are once again increasing, and warnings are being given regarding yet another laboratory-grade helium shortage, my thoughts turn once again to the use of hydrogen as an alternative carrier-gas for gas chromatography.

The Gulf Coast Conference (GCC) is held in Galveston annually. For the past 50+ years, this gathering of international scientists has blazed a trail for analytical needs and innovations for the refining and petrochemical industries.

Data Integrity has become a critical issue in the pharma industry as a result of increased regulatory scrutiny stemming from Data Integrity-related violations. This ebook provides insight on a variety of important topics within this space.

Click the title above to open the LCGC Europe July 2019 regular issue, Volume 32, Number 7, in an interactive PDF format.

As someone who has been associated very closely with poster presentations, I have to say, it is time for a change.

A group of researchers has investigated the impact of combined sewer overflow (CSO) on pharmaceutical and illicit drug use in central London using liquid chromatography–high-resolution mass spectrometry (LC–HRMS).

MilliporeSigma has announced the winners of its Advance Biotech Grant programme in North America.

A biennial meeting jointly organized by the Environmental Chemistry Group, Separation Sciences Group, and the Water Science Forum, and discussing the latest advances in the analysis of complex environmental matrices, is now in its eighth year. The most recent iteration of the event occurred on Friday 22 February 2019 in the Science Suite, Royal Society of Chemistry, Burlington House, in London, UK. This meeting review offers an overview of what is happening in the industry.

A preview of the upcoming 30th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2019), which is due to be held on 15–18 September 2019 at the Convention Centre of The Dan Panorama Hotel in Tel Aviv, Israel.

R.D. McDowall has written an excellent book on data integrity and data governance. Those who need to understand what this is should read the book and follow his advice. He has included both what the regulations and regulators say and what we need to do to be in compliance. This is a scalable approach with enhancements for larger items and shortcuts for smaller items, with numerous examples throughout the book.

Click the title above to open The Column July 2019 North American issue, Volume 15, Number 7, in an interactive PDF format.

Click the title above to open The Column July 2019 Europe & Asia issue, Volume 15, Number 7, in an interactive PDF format.

Click the title above to open the Current Trends In Mass Spectrometry July 2019 special issue in an interactive PDF format.

For liquid chromatography (LC) methods where the buffer pH and composition have an influence on retention, which buffer preparation method will provide the most repeatable results?

This instalment of “GC Connections” dives into temperature programming. First, the differences in peak widths and retention times between temperature programmed and isothermal chromatograms are examined. Why are all the peaks so sharp in temperature programmed GC, yet they get broader (and shorter) in isothermal GC? Next, we explore some early ideas about temperature programming and peak broadening that explain why the peaks are so sharp in temperature-programmed GC, and why the peak spacing is different from isothermal GC. Finally, we examine an important consequence of our ability to program temperature: the need for temperature programming in splitless and other injections that use “solvent effects” and other peak focusing mechanisms. These points are illustrated using several historical figures and chromatograms from the early days of GC.