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Click the title above to open the LCGC North America July 2019 issue, Volume 37, Number 7, in an interactive PDF format.

We examine the evolution of hybrid particle columns, highlighting examples of separations enabled by this technology.

The fundamentals of electron capture detectors, explained.

How has UHPLC has affected pharmaceutical research? The answer depends on your point of view.

In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.

The development of analytical instrumentation for harsh terrestrial environments and outer planet space exploration exponentially increases instrument requirements-for features such as robustness, autonomous operation, and speed-and poses unique system integration challenges. Here, we explore the use of laser thermal desorption coupled to comprehensive two-dimensional gas chromatography (LTD-GC×GC) for use with a compact, high-resolution mass spectrometer for challenging applications.

Exosomes are small lipid membrane-bound extracellular vesicles, on the order 30 – 150 nm in diameter, which are shed by normal and tumor cells in the body. They are circulating within your body and can be isolated from virtually any biological fluid. Exosomes released from tumor cells have been shown to be enriched in certain proteins. These nanobodies hold significant promise for the discovery of cancer biomarkers, for cancer diagnosis and prognosis, and for biomarker quantitation.

A morning session today on “Environmental: Innovative Approaches and Instrumentation,” will be held 8:30–10:30 am in Room B308–309. The session, chaired by Pierangela Palma of the University of Urbino, in Urbino, Italy, includes talks on a range of mass spectrometry techniques.

“Forensics: Innovations and Applications” will be held this afternoon from 2:30 to 4:30 pm in Room B405-407. The session, chaired by Travis M. Falconer, a chemist with the Forensic Chemistry Center of the US Food & Drug Administration in Cincinnati, Ohio, includes topics on analytes ranging from explosives to larvae.

Modern HPLC method development is dominated by a small number of pH adjusting reagents and buffers that are prevalent even when the method uses UV detection. This is driven primarily by the requirements of mass spectrometry.

The Research Awards will be presented today, at the beginning of the Biemann Medal Lecture session in the Murphy Ballroom, at 4:45 pm.

The Tuesday morning oral sessions on “Environmental: Emerging Contaminants” -in Honor of Ron Hites-will be held 8:30-10:30 am in Room B308–309. The session, chaired by Susana Y. Kimura of the Department of Chemistry at University of Calgary in Calgary, in Alberta, Canada, addresses analytical strategies for a range of environmental contaminants.

The Tuesday afternoon session on “Instrumentation: Innovative Separations Approaches Coupled to MS,” will be held 2:30-4:30 pm in the Auditorium of Building A. The session, chaired by Xing-Fang Li of the Department of Laboratory Medicine and Pathology at the University of Alberta, in Edmonton, Alberta, Canada, addresses analyses related to biology, proteomics, environmental studies, petroleum, and more.

Click the title above to open the LCGC Asia Pacific May/June 2019 regular issue, Volume 22, Number 2, in an interactive PDF format.

The morning session “Imaging: Instrumentation & Method Development,” will be held from 8:30 to 10:30 am in Room B302–305. The session, chaired by Martina Marchetti-Deschmann of the Faculty of Technical Chemistry at TU Wien in Wein, Austria, includes talks on a variety of aspects of mass spectrometry imaging.

The Monday afternoon session on “Food Safety & Chemistry: Foodomics, Allergens, Bacteria, Foods, and Supplements,” will be held 2:30-4:30 pm in Room B405-407. The session, chaired by Michelle Colgrave, Molecular Analysis Team Leader in CSIRO Agriculture and Food, based at the Queensland Bioscience Precinct in Brisbane, Australia, addresses topics related to the analysis of coffee, milk, carbohydrates, quinoa, wine, and more.

Click the title above to open The Column June 2019 Europe & Asia issue, Volume 15, Number 6, in an interactive PDF format.

Click the title above to open The Column June 2019 North American issue, Volume 15, Number 6, in an interactive PDF format.

This is the fifth in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2019 conference in Milan, Italy, from 16–20 June.

When can we use completely aqueous eluents with reversed-phase stationary phases, and what happens if we make a mistake?

In this excerpt from LCGC’s e-learning platform, CHROMacademy.com, recovery problems in solid-phase extraction (SPE) are discussed.

The Column spoke to Robert Shaw, Steph Turnbull, and Sophie Bailes from AstraZeneca about their work in quality by design (QbD) in the pharmaceutical industry.

Calling all innovators (or anyone seeking to justify a new instrument purchase)!

A newly developed HILIC stationary phase containing modified diol groups on a polymer-based particle has offered renewed hope of an alternative to IP-reversed-phase LC.