A new study reports the development a highly sensitive LC–MS/MS method to measure salivary melatonin levels. The method has a lower limit of the measuring interval of 0.8 pg/mL, making it the most sensitive method for quantifying melatonin in saliva.
A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.
Samples of the prefrontal cortex, striatum, and hippocampus of rats were analyzed by LC–MS to assess brain tissue response to combined consumption of ethanol and cocaine.
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A micro-pillar array format for mapping the proteome of human stem cell-derived liver organoids using timsTOF–MS is presented.
A new RPLC–MS method can map the substitution degree and composition of β-glucose monomers of cellulose ethers (CEs), providing detailed compositional distributions and constitutional isomer distributions, thereby identifying compositional variation between bio-stable and non-bio-stable CEs and unexpected methylations in EHEC samples.
A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.
The Chromatographic Society and the Separations Science Group of the Analytical Division of the Royal Society of Chemistry are pleased to announce Emerging Separations Technologies 2023 is to be held 24–25 May 2023, at RSC Burlington House, London, UK.
A rapid and robust LC–MS/MS method for determining lactulose and rhamnose concentrations in blood plasma was used to determine intestinal permeability from blood plasma, which can help diagnose gastrointestinal diseases such as Crohn’s disease.
This method has greater sensitivity and a shorter LC analysis time than the AOAC method. It also requires less instrument maintenance, enhances column lifetime by requiring a smaller sample volume, and reduces cost by replacing acetonitrile with methanol in the mobile phase.
Selective pressurized liquid extraction and multilayer solid‑phase extraction methods are described for high‑throughput plant, soil, and water sample preparations. Optimal analytical conditions are described for the improvement of detection sensitivities and coverage. A Source Supported Suspect Screening (4S) approach is described; phytotoxins detected in the source plant were used to improve the identification of phytotoxins in soil and water.
A new approach combining high performance liquid chromatography–mass spectrometry with ultrafiltration, along with enzyme channel blocking and directional enrichment, has been found effective for screening natural histidine decarboxylase inhibitors in Radix Paeoniae alba, while reducing both false-positive and false-negative results.
In the first of a two-part series, a recent study discusses a new strategy for assessing the peak purity of pharmaceutical peptides analysis using 2D-LC–MS.
Glyphosate and AMPA are two potentially dangerous chemicals within herbicides. Using LC–MS to detect these chemicals is important to human and environmental health.
Using LC–MS, scientists have developed a new method for testing doping steroids in blood.
Using an Analytical Quality by Design approach, scientists recently identified impurities in a pharmaceutical product for hypertension treatment.
Using liquid chromatography-tandem mass spectrometry, scientists have found a similarity between the protective functions of the oral permeability barrier and the skin barrier.
While pesticides may be beneficial, they may also cause health risks in foods. In a recent study, scientists created new methods for detecting maximum pesticide residue levels.
Dipeptide profiles have an important role in detecting disease, and a recent study has made it much more accessible to study them.
By performing tissue analysis of caracals in captivity and in their natural African habitats, scientists were able to quantify uptake of toxic chemicals from the environment depending on how polluted they are.
A recent study was conducted using liquid chromatography–tandem mass spectrometry (LC–MS/MS) to identify the effect of cooking and storage on poly)phenolic compounds in piquillo peppers.
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