Liquid Chromatography (LC/HPLC)

Everyone is talking about sustainability, and organizations are creating sustainability programs. But what does green chemistry really mean, and how does it apply to gas chromatography?

Manitoba Centre for Proteomics and Systems Biology scientists produced a new means of predicting peptide retention times for hydrophilic interaction liquid chromatography (HILIC) at acidic pH in formic-acid based eluents.

Here is some of the most popular content posted on LCGC International this week.

Biotech Fluidics recently released the Biotech Micro Flow Meter, a tool for continuously monitoring the consistency of nanoscale dispensing systems as well as UHPLC and LC/MS solvent/reagent delivery systems.

Biotech Fluidics reports that Dr Maisch HPLC GmbH have installed a Biotech Liquid Micro Flow Meter in their testing set-up to validate the performance of all capillary columns it manufactures.

Scientists from the Institute of Analytical Chemistry of the Czech Academy of Sciences and Masaryk University recently tested various saliva sampling methods to optimize bile acid analysis.

Michael G. Bartlett of the University of Georgia looked at how hydrophilic interaction liquid chromatography (HILIC) has evolved for oligonucleotide analysis in a new article.

Here is some of the most popular content posted on LCGC International this week.

This review aims to provide a summary of the most current analytical techniques and their applications in per- and polyfluoroalkyl substances (PFAS) research, contributing to the ongoing efforts to monitor and mitigate PFAS contamination.

Raquel Gonzalez de Vega of the University of Graz recently spoke to us about her work tracking per- and polyfluoroalkyl substances (PFAS) in ski wax products.

It has been more than five years since the last update in this column on the evolution of the Hydrophobic Subtraction Model (HSM) of reversed-phase selectivity and characteristics of new stationary phases recently characterized using the model. In this installment, Dwight Stoll discusses the continuing evolution of the model.

ISC 2024 in Liverpool, U.K. included an illuminating session on contemporary omics applications.

Hydrophilic interaction chromatography–mass spectrometry (HILIC-MS) offers a flexible and efficient alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for oligonucleotide analysis, with column selectivity and mobile phase pH being key factors in optimizing retention and detection.

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Analyzing functional foods reveals numerous health benefits. These foods are rich in bioactive compounds that go beyond basic nutrition, boosting the immune system and improving overall wellness. However, analyzing these compounds can be challenging. This article discusses AI algorithms to support automated method development for liquid chromatography, simplifying the process, enhancing labor efficiency, and ensuring precise results, making it accessible to non-experts for tea analysis.

The European Commission's regulation on maximum levels for certain contaminants in food highlights the need for precise and reliable methods to quantify per- and polyfluoroalkyl substances (PFAS) in various food matrices. This article discusses development and validation of a robust method for analyzing 21 PFAS compounds in chicken eggs using solid-phase extraction (SPE) and liquid chromatography–mass spectrometry (LC–MS).

Here is some of the most popular content posted on LCGC International this week.

As part of our ISC 2024 coverage, we recently interviewed Anneli Kruve of Stockholm University about her scientific background and her presentation about eludicating toxic chemicals' structures using LC/HRMS.

Scientists from around the world presented their groundbreaking technologies for in-field chromatography analysis during the International Symposium on Chromatography (ISC) in Liverpool, U.K.

As part of our ISC 2024 coverage, we recently interviewed Bram Huygens of Vrije Universiteit Brussel about his scientific background and his thoughts on receiving our Rising Stars of Separation Science Award for Liquid Chromatography.

As part of our ISC 2024 coverage, we recently interviewed Alexandre Goyon of Genentech about his research and his being awarded our Rising Stars of Separation Science Award for Outstanding Achievement in Pharmaceutical Analysis.

As part of our ISC 2024 coverage, we recently interviewed Amarande Murisier of the University Hospital of Lausanne, Switzerland (CHUV) about her winning the Rising Stars of Separation Science Award for Biopharmaceutcal Analysis and her scientific background.

Bram Huygens’ research focuses on developing a deeper understanding of the factors influencing separation efficiency by using advanced mathematical techniques to analyze mass transfer phenomena.

Here is some of the most popular content posted on LCGC International this week.

ETHZ and Agroscope scientists tested a new means of analysis against secondary electrospray ionization (SESI) coupled to high-resolution-mass spectrometry (HRMS) for exhaled breath analysis.