Mass Spectrometry

While mass spectrometry (MS) is the favored analytical technique for the primary structures of proteins and their post-translational modifications (PTMs), the combinatorial isomers that commonly co-occur necessitate a more advanced approach.

Researchers at West Virginia University introduce an algorithm which, in combination with binary classifiers, enables accurate and specific identification of cocaine in mass spectra from various laboratories, outperforming traditional approaches.

To gain a better understanding of phosphatidylinositols, scientists used different LC–MS/MS techniques to find classifications to use in identifying further species of Pls.

HRMS is widely used in chromatography for analyzing complex mixtures. However, chromatographers should take note of the exponentially larger data set that HRMS provides before deciding whether to use the technique for the analysis they are conducting.

Increases and decreases in anthocyanin concentration, which relates to the level of sugars found in red wine, were observed at specific weekly intervals of the grape ripening process.

Trypsin is one of the most commonly used proteases in peptide mapping protocols because of its high level of specificity. However, trypsin alone is not always sufficient for full sequence coverage. In this article, the authors detail how trypsin was combined with chymotrypsin to overcome this, and the benefits of an automated platform.

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

Understanding separation principles is the key to success. Here's why.

Plant growth regulators (PGRs) have significant effects on plant physiological processes, but the complex matrices of plants, along with polarity and instability issues inherent with PGRs, complicate trace analysis of these compounds.

In this interview, we explore the significance of this groundbreaking technology and its impact on mass spectrometry with Aaron Robitaille, Director of Marketing for Mass Spectrometry at Thermo Fisher Scientific in San Jose, California.

Sauce-flavor or sauce-aroma baijiu, one variant of a popular Chinese liquor, is treated with a fermentation starter called daqu, giving the concoction a unique taste profile, and scientists want more information about how it can inform the manufacturing of higher-quality baijiu.

Scientists at NACRW discussed using CE–MS to analyze highly polar agrochemicals.

During the North American Chemical Residue Workshop, scientists discussed predicting liquid chromatographic retention times to identify contaminants.

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Among the compounds of concern found in the samples were nicotine-related alkaloids, psychoactive cannabinoids, and chemicals that promoted inflammation of the respiratory system.

While both branched-chain fatty acids (BCFAs) and straight-chain fatty acids (SCFAs) were analyzed, the profiling of BCFAs was considered especially important for future metabolomics and lipidomics studies.

High-throughput proteomic research has been hampered by the limited peak capacity of one-dimensional liquid chromatography (1D-LC) separation performance.

A water-resistant, highly adsorptive molecularly imprinted polymer was developed to address the issues of unstable adsorption performance and high organic solvent consumption in traditional materials.

Authentication of popular ginseng-based products has been difficult and has caused confusion in quality control between traditional Chinese medicine (TCM) and Chinese patent medicine (CPM).

Quality control of raw hazelnuts is already a highly specific process, but has limitations including operator influence, duration, and lack of standardization. AI is now assisting in quality decision-making using GC×GC analysis.

Although closantel (CLO) is well-regarded as a curative antiparasitic drug, even low doses have been found to cause serious side effects in the human retina and central nervous system.

Stephanie Rankin-Turner and colleagues at Johns Hopkins Bloomberg School of Public Health have recently performed research in Zambia indicating that mosquitoes are more attracted to humans who exhibit abundant levels of certain volatile carboxylic acids.

Examining the role that LC–MS/MS plays in metabolomics, and metabolomics’ growing importance in the field of disease biology.

This article details a recent experiment that demonstrates how nonspecific interactions can be prevented by using metal-free or low adsorption flow paths.

While most diapers do not contain all 15 polycyclic aromatic hydrocarbons (PAHs), the concentration of these compounds varies by manufacturer, and no disposable diaper is entirely free of PAHs.