Although closantel (CLO) is well-regarded as a curative antiparasitic drug, even low doses have been found to cause serious side effects in the human retina and central nervous system.
Stephanie Rankin-Turner and colleagues at Johns Hopkins Bloomberg School of Public Health have recently performed research in Zambia indicating that mosquitoes are more attracted to humans who exhibit abundant levels of certain volatile carboxylic acids.
Examining the role that LC–MS/MS plays in metabolomics, and metabolomics’ growing importance in the field of disease biology.
This article details a recent experiment that demonstrates how nonspecific interactions can be prevented by using metal-free or low adsorption flow paths.
While most diapers do not contain all 15 polycyclic aromatic hydrocarbons (PAHs), the concentration of these compounds varies by manufacturer, and no disposable diaper is entirely free of PAHs.
The combination of deep eutectic solvents (DESs) and cellulose paper, according to the researchers, bridges a current gap in sustainable, paper-based sorptive phases.
Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) are suspected to be carcinogenic, and improvements are sought to improve gas chromatography–mass spectrometry (GC–MS) methods traditionally used for this analysis.
Researchers have introduced a novel primary method utilizing gas chromatography–isotope dilution infrared spectrometry (GC–IDIR) for accurate peptide purity analysis.
Researchers have developed a robust method utilizing high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) to accurately quantify amino acids in plasma, making it a valuable tool for clinical diagnostics and research in amino acid metabolism.
A novel isotopologue was synthesized in a stable isotope dilution assay (SIDA) for quantification of γ-nonalactone for the first time in pinot noir wines from New Zealand.
Enhancements in chromatographic performance were reviewed as were experimental concerns, both pointing toward using specific solvents to influence more sustainable industrial development.
Scientists have developed a novel sorbent, diphenyl-functionalized nickel foam (NF-2Ph), for the accurate detection of polycyclic aromatic hydrocarbon (PAH) contaminants in Chinese herbal medicines. The method, which combines dispersive solid-phase extraction (DSPE) with gas chromatography-mass spectrometry (GC–MS) analysis, offers high sensitivity and precision, providing a reliable approach for quality control and safety assessment of these medicinal products.
A new method for automatic z-axis correction during mass spectrometry imaging of uneven surfaces has been developed, allowing for accurate molecular analysis of complex samples. This advancement enhances the reliability and reproducibility of mass spectrometry imaging, enabling researchers to visualize the spatial distribution of molecules in challenging samples with uneven topographies.
Scientists from the Pacific Northwest National Laboratory are using high-resolution ion mobility spectrometry-mass spectrometry to identify unknown compounds.
New research using matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has revealed the distinct distributions of acetaminophen and its metabolite in the kidneys at an unprecedented resolution of 10 μm. The study, conducted by Mitsutoshi Setou and his team from Hamamatsu University School of Medicine in Japan, provides valuable insights into drug distribution and metabolism, enhancing our understanding of the pharmacokinetics and potential nephrotoxicity of acetaminophen.
Pop quiz – can you define resolution? Would you be surprised at the number of correct answers? Which one is the best for chromatographers? In this LCGC Blog, we look at the various ways resolution can be interpreted scientifically.
Levoglucosan, which is emitted from the combustion of cellulose and hemicelluloses, can be transported over a long range of time to ice caps, where it may indicate fire activity both regionally and globally.
Gas chromatography coupled to mass spectrometry (GC–MS) has been the gold standard in this application, but its limitations in differentiating cancer subtypes have led to the exploration of newer related technologies.
Researchers have discovered that phospholipids form doubly charged lipid-metal ion complexes during electrospray ionization (ESI), providing valuable insights into the analysis of phospholipid structures.
Researchers have developed an ultrahigh-pressure liquid chromatography (UHPLC)—tandem mass spectrometry (MS/MS) method for the simultaneous determination of 10 aminoglycoside antibiotics in aquatic products.
A recent study reveals that pesticide residues in herbs have a low transfer rate to herbal infusions, ensuring safer consumption of these products. The validated analytical method used in the study provides valuable insights into the levels of pesticide residues in herbs and their limited presence in the resulting infusions.
The subatmospheric pressure laser desorption ionization-mass spectrometry platform proposed here showed potential for mapping low-abundance biomarkers.
Researchers said they have devised a novel setup using a secondary electrospray ionization-high resolution mass spectrometry (SESI-HRMS) platform to detect bacterial cultures in cells that are vital to immune and memory functions.
Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.
A research team has developed a new approach for selecting precursor ions in tandem mass spectrometry (MS/MS) experiments called DiffN, which increases the likelihood of biomarker discovery and provides a promising tool for lipidomic analyses.
