Mass Spectrometry

A systematic approach to method improvement can save time and resources by using methods that are likely to be better, and more robust, than those developed using a trial-and-error approach.

Some traditional MAM workflows are being substituted with iMAM workflows that rely on analyzing the intact mass of mAbs in their native form, resulting in significant improvements in high-throughput sample analysis.

A novel LC–MS/MS method, with a dual ESI and APCI source using simple solvent extraction for sample preparation, was validated for analysis of 102 pesticides and 5 mycotoxins regulated by Colorado state in dried hemp.

The monitoring of per- and polyfluoroalkyl substances (PFAS) into food is an important environmental and health concern. Raquel Sendón García, PhD, is a Faculty Member in the Department of Analytical Chemistry of Nutrition and Food Science, and a Faculty of Pharmacy member at the University of Santiago de Compostela in Spain. She has been performing research on food contamination and the presence of potentially harmful chemicals in foods for some time. We recently spoke to her about her work using GC–MS and other analytical techniques to analyze PFAS migration into food from packaging materials.

Webinar Date/Time: Wednesday, April 19, 2023

Webinar Date/Time: Thu, Apr 20, 2023 11:00 AM EDT

Many new HPLC and MS products were launched in 2022–2023. This conference coverage article discusses several of these new products, including their salient features, benefits, and technical specifications.

A general discussion of the megatrends of separation science equipment (both high performance liquid chromatography [HPLC] and mass spectrometry [MS]) and their applications in recent years is presented.

Webinar Date/Time: Thu, Apr 6, 2023 11:00 AM EDT

Webinar Date/Time: Europe: Thursday, March 30th, 2023 at 2pm BST | 3pm CEST | 9am EDT North America: Thursday, March 30th, 2023 at 1pm EDT | 10am PDT | 6pm BST Asia: Friday, March 31st, 2023 at 12pm JST | 11am CST | 11pm EDT

Neil Kelleher received the 2023 Pittsburgh Analytical Chemistry Award for his contributions to analytical chemistry. He was recognized at Pittcon 2023, which took place in Philadelphia, Pennsylvania.

Webinar Date/Time: Thu, Mar 9, 2023 11:00 AM EST

Webinar Date/Time: Airing 1: Tuesday March 14, 2023 at 9am EST | 2pm GMT | 3pm CET Airing 2: Tuesday March 14, 2023 at 2pm EST | 1pm CST | 11am PST

Webinar Date/Time: Thu, Mar 2, 2023 11:00 AM EST

In this study, a probe electrospray ionization coupled to mass spectrometry (PESI-MS) method for ultra-rapid determination of MtF in plasma by isotope dilution was developed.

Webinar Date/Time: Tuesday, February 21st, 2023 Morning session: 9:30 am EST - 12:15 pm EST Afternoon session: 2:00 pm EST - 4:00 pm EST Wednesday, February 22nd, 2023 Morning session: 9:30 am EST - 12:15 pm EST Afternoon session: 2:00 pm EST - 4:00 pm EST

A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.

Webinar Date/Time: Monday, March 27th at 11am EDT|8am PDT|4pm BST|5pm CEST

Webinar Date/Time: Airing 1: Tuesday January 17, 2023 at 9am EST | 2pm GMT | 3pm CET Airing 2: Tuesday January 17, 2023 at 2pm EST | 1pm CST | 11am PST

This month we interview Raviraj Chandrakant Shinde from India, about his work on the analysis of various food contaminants using chromatography and mass spectrometry, and the challenges involved in analyzing polar and ionic pesticides.

This review article summarizes the results obtained from the combined efforts of a joint academic and industrial initiative to solve the real-life challenge of determining low levels of peptide-related impurities in the presence of the related biologically-active peptide at a high concentration.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Webinar Date/Time: Monday, November 28 2022 at 11 am EDT

How to lower the limits of quantitation as the regulatory landscape continues to evolve.

Non-targeted analysis of small molecules with ambient ionization mass spectrometry (AI-MS) is enabled by new mass spectral libraries and algorithms, such as the inverted library search algorithm (ILSA) developed at NIST.

Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.

Gene therapy vectors in the gigadalton (GDa) regime are beyond the range of conventional mass spectrometry. Charge-detection MS overcomes this limitation.

Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.

In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.

An overview of modern approaches to small-molecule drug discovery.