Mass Spectrometry

Matrix interferences can impact routine analysis with triple quadrupole methods for monitoring and quantifying PFAS in food.

The success of screening column and mobile phase combinations that generate dissimilar selectivity is highlighted in a typical method development strategy.

Recent developments in GC×GC that make it more amenable for routine use are discussed.

This instalment of “Column Watch” presents many of the highlighted topics and trends observed at this exceptionally well-run symposium.

Webinar Date/Time: Monday, September 25th, 2023 Morning Session: 12:30pm BST | 7:30am EDT | 13:30pm CEST Afternoon Session: 15:20pm BST | 10:20am EDT | 16:20pm CEST Tuesday, September 26th, 2023 Morning Session: 12:30pm BST | 7:30am EDT | 13:30pm CEST Afternoon Session: 15:00pm BST | 10:00am EDT | 16:00pm CEST

On Thursday, September 28, 2023, the Chromatographic Society (ChromSoc) will hold a meeting focused on gas chromatography in the Science and Industry Museum, in Manchester, UK.

As part of the upcoming Recent Advances in Gas Chromatography meeting, Laura McGregor of SepSolve will discuss how workflows for comparing 1D and 2D GC–MS chromatograms can be automated.

As part of the upcoming Recent Advances in Gas Chromatography meeting, Nicholas Morley will look at how two-dimensional gas chromatography-time-of-flight-mass spectrometry analyzes pharmaceutical packaging.

Two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC/TOF-MS) and gas chromatography–time-of-flight mass spectrometry (GC-TOF-MS), two different gas chromatography techniques, will have their procedures and uses compared at the Science and Industry Museum, in Manchester, UK.

The combination of the “bottom-up” approach with digest-free, direct-sequencing proteomics, along with the addition of a proteogenomics pipeline that identified missing data, yielded the determination of almost 3000 proteins.

Using mass spectrometry and fingerprint analysis, scientists are investigating a new way to screen for lung cancer.

Researchers in China studied a new process for measuring aberrant metabolites.

Studies published over the last five years have focused on fully or semi-automated approaches and their applications in extraction of both organic and inorganic pollutants, while modern robotic tools and 3D printing are starting to make impacts.

A recent study described how a new secondary ion mass spectrometer coupled with microscope mode detection allows for rapid mass spectral imaging over a larger surface area.

As researchers demonstrated in a second recent report, their devised method was effective for identification of cocaine, but there is no consensus as to a “best” algorithm for all necessary scenarios.

What critical components can help to resolve the separation challenges related to pesticides analysis in food?

Webinar Date/Time: Thursday, September 7, 2023 at 9am EST and 2pm ES

While mass spectrometry (MS) is the favored analytical technique for the primary structures of proteins and their post-translational modifications (PTMs), the combinatorial isomers that commonly co-occur necessitate a more advanced approach.

Researchers at West Virginia University introduce an algorithm which, in combination with binary classifiers, enables accurate and specific identification of cocaine in mass spectra from various laboratories, outperforming traditional approaches.

To gain a better understanding of phosphatidylinositols, scientists used different LC–MS/MS techniques to find classifications to use in identifying further species of Pls.

HRMS is widely used in chromatography for analyzing complex mixtures. However, chromatographers should take note of the exponentially larger data set that HRMS provides before deciding whether to use the technique for the analysis they are conducting.

Increases and decreases in anthocyanin concentration, which relates to the level of sugars found in red wine, were observed at specific weekly intervals of the grape ripening process.

Trypsin is one of the most commonly used proteases in peptide mapping protocols because of its high level of specificity. However, trypsin alone is not always sufficient for full sequence coverage. In this article, the authors detail how trypsin was combined with chymotrypsin to overcome this, and the benefits of an automated platform.

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

Understanding separation principles is the key to success. Here's why.