October 9th 2024
Scientists from Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE-CNRS) in Orléans, France and Chromatotec in Saint-Antoine, France recently created a new algorithm for detecting volatile organic compounds (VOCs) in ambient air.
New Ultrasensitive LC–MS/MS Method Allows for Accurate Melatonin Quantification in Human Saliva
May 8th 2023A new study reports the development a highly sensitive LC–MS/MS method to measure salivary melatonin levels. The method has a lower limit of the measuring interval of 0.8 pg/mL, making it the most sensitive method for quantifying melatonin in saliva.
Study Finds That Using Seven Points Across a Peak Is Sufficient for Accurate LC–MS/MS Quantitation
May 8th 2023A recent study has found that using only seven points across an LC–MS/MS peak can provide sufficient accuracy and precision for drug quantitation studies in drug discovery and development, challenging the "rule-of-thumb" of using at least 15 points.
SPME Arrow Improves Upon Conventional SPME in GC×GC–MS Analysis of Whiskey Flavor Compounds
May 5th 2023A solid-phase microextraction (SPME) Arrow combined with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) identified about 40 more volatile compounds in a variety of whiskeys compared to conventional SPME.
New Study Identifies Potential for Anticancer Drugs in Solanum Nigrum Fruits
May 5th 2023A recent study analyzed the composition and metabolism of steroidal alkaloids in Solanum nigrum fruits of different maturities and identified steroidal glycoalkaloids and steroidal alkaloids, providing a foundation for further research on biosynthesis and discovery of new steroidal alkaloid anticancer drugs.
Proteotypic Peptides of Hairs Can Be Used for Species Identification Using Mass Spectrometry
May 5th 2023A new published study introduces a simple and fast way to differentiate between animal species based on their hair. The in-sample digestion method coupled with mass spectrometry analysis was successfully tested on multiple species.
New Mass Spectrometry Tool to Quantify Cell Heterogeneity and Subpopulations in Cancer
May 2nd 2023Researchers combine a single-probe single cell mass spectrometry technique with a bioinformatics software package to quantify cell subpopulations and prioritize metabolite biomarkers, providing a label-free approach to studying cell heterogeneity and improving understanding of cell metabolism in human diseases and response to therapy.
New Method Developed to Map Cellulose Ether Monomer Composition
May 2nd 2023A new RPLC–MS method can map the substitution degree and composition of β-glucose monomers of cellulose ethers (CEs), providing detailed compositional distributions and constitutional isomer distributions, thereby identifying compositional variation between bio-stable and non-bio-stable CEs and unexpected methylations in EHEC samples.
Using HPLC–MS and GC–MS for Improving Speed and Accuracy of Organosulfur Compound Detection
May 2nd 2023High performance liquid chromatography–mass spectrometry and gas chromatography–mass spectrometry, along with numerous extraction methods, are helping to find organosulfur compounds in food more easily, providing researchers better information about the health benefits of these substances.
Exploring Biopharmaceutical Analysis with Compact Capillary Liquid Chromatography Instrumentation
A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.
A Novel Mass Spectrometry Paradigm to Analyze Classical and New Biotherapeutic Modalities
May 1st 2023A new fragmentation approach—tunable electron-activated dissociation (EAD) tandem mass spectrometry (MS/MS)—offers a solution to better improve the detection and characterization of impurities in lipid nanoparticles and impurities in other biopharmaceutical modalities.
An LC–MS/MS Method for the Evaluation of Intestinal Permeability in Blood Plasma
May 1st 2023A rapid and robust LC–MS/MS method for determining lactulose and rhamnose concentrations in blood plasma was used to determine intestinal permeability from blood plasma, which can help diagnose gastrointestinal diseases such as Crohn’s disease.
Demystifying Sample Preparation for Headspace Analysis Using Direct Injection Mass Spectrometry
May 1st 2023Direct-injection mass spectrometry (DIMS) and gas chromatography (GC) approaches have some significant differences that are pertinent when analyzing volatile organic compounds (VOCs). We explain.
Analysis of PFAS in Locally Acquired Food Containers
May 1st 2023The combination of an untargeted approach using ultrahigh pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF) and a targeted approach using UHPLC–tandem mass spectrometry (MS/MS) are presented as an ideal method for detecting per- and polyfluroalkyl substances (PFAS) in fast-food packaging.
LCE and LCA: Suspect Screening of Lupin-Produced Phytotoxins in Environmental Samples
April 30th 2023Selective pressurized liquid extraction and multilayer solid‑phase extraction methods are described for high‑throughput plant, soil, and water sample preparations. Optimal analytical conditions are described for the improvement of detection sensitivities and coverage. A Source Supported Suspect Screening (4S) approach is described; phytotoxins detected in the source plant were used to improve the identification of phytotoxins in soil and water.
GC✕GC–TOF-MS Helps Quantify Pesticides in Water Susceptible to Contamination
April 28th 2023Pesticides in local surface and groundwaters were purified and enriched with solid-phase extraction, then analyzed using multidimensional gas chromatography coupled to mass spectrometry, with the results compared to those found by gas chromatography–quadrupole mass spectrometry.