Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.
A recent study out of Jeonbuk National University evaluated data integration methods for the isotopic analysis of lead at ultratrace levels.
Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.
Scientists in Mexico developed a new method for detecting herbicides in agricultural soil, being based on techniques like 9-fluorenylmethyl chloroformate (FMOC-Cl) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
Weronika Hewelt-Belka, an assistant professor at Gdańsk University of Technology in Poland, answers questions about her research analyzing GM3 gangliosides in human milk, elucidating their molecular distribution and dynamic changes throughout lactation.
The process was assisted by pH-dependent acid-base partitioning coupled with salting-out-assisted liquid-liquid extraction (LLE).
A recent study from the Shangdong Academy of Chinese Medicine examined chicory using a novel UHPLC–HRMS technique and rats as the test subject.
A polydimethylsiloxane (PDMS) silicone rubber band sampler was used to collect volatile organic compounds (VOCs) from the skin of both tuberculosis (TB)-positive and TB-negative subjects.
Scientists from Utah and Ireland recently created a liquid chromatography–mass spectrometry (LC–MS) analytical method capable of detecting phototoxins in essential oils.
Webinar Date/Time: Tue, Feb 13, 2024 11:00 AM EST
In our second edition of “Inside the Laboratory,” Zhibo Yang, PhD, an associate professor of chemistry at the University of Oklahoma, discusses his group’s most recent work in single-cell mass spectrometry (MS) and MS tissue imaging.
LCGC and Spectroscopy Editor Patrick Lavery spoke with Oligo Factory CEO Chris Boggess about the company ’s recently attained compliance with Good Manufacturing Practice (GMP) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Expert Working Group (Q7) guidance and its distinction from Research Use Only (RUO) and International Organization for Standardization (ISO) 13485 designations.
Non-alcoholic beers are becoming more popular and need to reflect the sophisticated flavourings of beers that are brewed containing alcohol. Sophisticated analytical techniques can help to achieve this.
Rolduc 2024 takes place from 28–30 April 2024 in Rolduc Abbey, Kerkrade, The Netherlands.
Scientists in Xi’an, China have created a novel system for the analysis of cell membranes, based around haloalkane dehalogenase protein tag (HALO)-tag technology. Their research was published in Talanta.
The International School on Mass Spectrometry (IntSMS) returns in 2024, and it will take place on September 9–14th at the Ettore Majorana Foundation and Centre for Scientific Culture (EMFCSC) in Erice, Italy.
Webinar Date/Time: Thu, Feb 8, 2024 11:00 AM EST
In this LCGC Blog, the author explores stationary phases that incorporate permanent or induced charges within, or alongside, hydrophobic alkyl silica type bonded ligands.
Scientists from Washington and Connecticut have created a new system to detect epithelial ovarian cancer (EOC).
Researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College categorize the cardioprotective effects and other characteristics of flavonoids from the species commonly known as Chinese rosewood.
To detect certain pesticides in rice, wheat, and maize, scientists recently developed a new SFC-MS/MS technique.
Metabolite characterization can be complex. In this study, researchers at Yeungnam University used feature-based molecular networking (FBMN) to further understand glutathione (GSH) adducts.
This review article discusses scientific rationales and current best practices in the pharmaceutical industry for performing chromatographic peak purity assessments (PPA). These activities are associated with the development and validation of liquid chromatographic (LC) stability-indicating analytical methods applicable to regulatory submissions of small-molecule drug candidates. The discussion includes a comprehensive overview of the PPA-related regulatory and scientific landscape and common industry approaches to obtain PPA results, as well as the strengths and weaknesses of PDA-facilitated ultraviolet (UV) PPA and other PPA techniques.
A variety of chromatographic techniques have been used to quantify the full range of acyl-CoAs, formed when a fatty acid bonds with coenzyme A, but added complexity and analysis time adversely affect the level of throughput.
A group of scientists tested a new means of analyzing lipids in brain tissue using mass spectrometry imaging (MSI).
