Mass Spectrometry

The advantages of a native anion exchange method coupled to mass spectrometry for charge heterogeneity analysis of immunoglobulin G4 (IgG4)-based mAbs are described.

At Pittcon 2024, LCGC International editor Patrick Lavery sat down with John R. Yates of the Scripps Research Institute to talk about his work in mass spectrometry and proteomics.

Researchers from Austria, Greece, and Italy conducted a study to analyze volatile organic compounds (VOCs) present in Irish and Scotch whiskys using solid-phase microextraction (SPME) Arrow with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) to examine the organoleptic characteristics that influence the taste of spirits.

This study attempted to improve upon assessment of quality prior to processing of single cell proteomics data, describing a “lightweight” script of fewer than 100 lines of code written in the programming language Python.

A recent study examined using high performance liquid chromatography (HPLC) with inductively coupled plasma–tandem mass spectrometry (ICP-MS) to detect ethylene-thiourea (ETU) and propylene-thiourea (PTU) in fruits and vegetables.

Scientists from Hangzhou, China used ultra-performance liquid chromatography mass spectrometry and non-targeted metabolomics studies to help find treatments for colorectal cancer.

A new study from Guangxi Normal University examines biogenic amine (BA) detection in food samples by using surface-assisted laser desorption/ionization–time-of-flight mass spectrometry (SALDI–TOF-MS) in conjunction with a molecularly imprinted polymer (MIP).

Scientists from Murcia, Spain recently created a new method for mycotoxin screening in human tissues using dispersive liquid–liquid microextraction and liquid chromatography–mass spectrometry.

Sara E. Kern and her team of the U.S. Food and Drug Administration (FDA) tested different analysis methods for rapidly screening for poppy seeds in food samples.

A group of Taiwanese scientists have recently created a new method for assessing food quality and detecting histamine in wine samples.

These lectures focused on method development and applications of mass spectrometry for bioanalytical, natural product, and agricultural studies.

At Pittcon 2024, Pittsburgh Analytical Chemistry Award winner John Yates headlined a symposium focusing on perfecting proteome research down to the single-cell level.

During a workshop at Pittcon, David Alonso of LECO Corporation discussed how gas chromatography–time-of-flight mass spectrometry (GC-TOFMS) can be used to identify polyfluorinated alkyl chemicals (PFAS) chemicals in anti-fog product solutions.

On February 25, a Pittcon oral session, titled “Detection of PFAS and other Polyfluorinated Analytes,” took place at the San Diego Convention Center in San Diego, California. This session included six talks that covered a variety of analytical techniques currently being used in per- and polyfluoralkyl (PFAS) analysis.

The tool, written in the Python programming language, was designed to rapidly quantify the reporter ion peaks in a file within each of its tandem mass spectrometry (MS/MS) spectra.

A new method has been developed to provide a sensitive, accurate and convenient GC–MS method to align with the new European regulation in relation to the introduction of the new Accutrace Plus marker for fuels.

The 18th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology will take place from 28–31 May 2024 in Leuven, Belgium.

Blood and sputum are the most common means of detection by diagnostic tests, but producing adequate sputum can be difficult given a dry cough is often a TB symptom.

Because the biophysical and biochemical parameters of peripheral blood plasma are often greatly altered in monoclonal gammopathy, conventional mass spectrometry measurements can be limited.

Researchers utilized individual ion mass spectrometry to analyze the heterogeneous glycan profiles of recombinant coronavirus spike proteins, detailing their structural intricacies.

Researchers from Nanjing University of Chinese Medicine leveraged ultrahigh-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) and network pharmacology to identify potential quality markers of three processed Qingpi products and elucidate their mechanism in liver disease treatment.

A recent study out of Jeonbuk National University evaluated data integration methods for the isotopic analysis of lead at ultratrace levels.

Researchers employed advanced chromatography and mass spectrometry techniques to unravel the chemical components and metabolites of Lingbao Huxin Dan, pinpointing its therapeutic potential for cardiovascular ailments.

Scientists in Mexico developed a new method for detecting herbicides in agricultural soil, being based on techniques like 9-fluorenylmethyl chloroformate (FMOC-Cl) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).

Weronika Hewelt-Belka, an assistant professor at Gdańsk University of Technology in Poland, answers questions about her research analyzing GM3 gangliosides in human milk, elucidating their molecular distribution and dynamic changes throughout lactation.