Mass Spectrometry

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Cell membrane structure, Lipid bilayer 3d illustration | Image Credit: © Artur - stock.adobe.com

Characterizing lipid nanoparticles (LNPs) is a developing delivery modality in biotherapeutic analysis. We address some of the current challenges and opportunities in this field, including an examination of the most common tools used to characterize LNPs.

Green corn field with corn cobs close up | Image Credit: © kyrychukvitaliy - stock.adobe.com

A new study introduces a comprehensive two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC–MS/MS) method for the analysis of 112 pesticides in corn-based products. The method exhibits high precision, lower limit of quantification values, and successful detection of trace levels of pesticides in real samples, offering promise for the analysis of complex matrices.

Collection of black fingerprints made with ink, isolated on a white background. Human fingerprint. | Image Credit: © domnitsky - stock.adobe.com

Scientists have developed a new method for predicting and assessing the source of black inks using direct analysis in real-time mass spectrometry. By applying dimensionality reduction techniques and likelihood ratio analysis, the researchers achieved high accuracy in identifying ink sources, demonstrating the potential of this approach in forensic ink analysis.