Supercritical Fluid Chromatography (SFC)

Kevin Schug explains how surrogate optimization streamlines SFE–SFC–MS method development, achieving R² values up to 0.97 while boosting sensitivity by 15%

LCGC International spoke to Cristian Reale about an eco-friendly SFC-PDA method that rapidly measures furocoumarins in Citrus essential oils.

In preparative chiral supercritical fluid chromatography (SFC), adding 2.5–5% water cuts retention times and narrows collection windows, boosting throughput.

Princeton Chromatography's Jeff Caldwell says SFC can now complete separations in 10–15 seconds.

Perception, not technology, remains the biggest barrier to supercritical fluid chromatography (SFC) adoption, says JASCO's Tom DePhillipo.

A history of the James L. Waters Symposium at Pittcon, from its 1987 origins and its founder, instrument entrepreneur James Logan Waters, through thirty-six installments of speakers spanning gas chromatography to generative AI.

SFC Europe 2025—the 19th International Conference on Packed Column Supercritical Fluid Chromatography and Related Techniques—will be held in Basel, Switzerland, on October 5–7, 2025. LCGC International spoke to John Reilly, Maria Kristina Parr, and Larry Miller about the important role that SFC now plays in life science analysis

Researchers from Sapienza Università di Roma and ETH Zürich investigated the performance of micro- and nano-liquid chromatography systems by examining how capillary LC behaves under varying operational conditions.

To better analyze components from chaga (Inonotus obliquus) mushrooms, researchers created a supercritical fluid chromatography (SFC)-based approach to collecting and quantifying chaga components.

To better analyze polyphenols, scientists from Sapienza University of Rome examined the capabilities of supercritical fluid chromatography (SFC), comparing it to traditional methods.

In this article, you’ll find some of the top content that was published on LCGC this week, including a technical article on food flavor and an interview with the president of Shimadzu Europa.

This study delves into the challenges of online coupling, offering solutions to overcome peak distortion and enhance reliability in complex sample analysis. The resulting LC×SFC–MS/MS analysis allows differentiation of isomers in very complex samples, regardless of similar fragmentation patterns.

This article explores the use of chromatographic retention measurements in both LC and SFC to develop quantitative retention activity relationship (QRAR) models, offering a predictive tool for skin permeability without animal testing.

Separating stereoisomers is an extensively researched and challenging process, with approved substances being rare. A new SFC-based system was made to possibly ease some aspects of these procedures.

Shimadzu researchers aimed to develop a more efficient supercritical fluid chromatography method for solid-state injection and streamlining sample pretreatment.

This morning at Pittcon, The Chromatography Forum of Delaware Valley (CFDV) held an award session for the late Terry Berger, who was this year’s recipient of the Del Nogare Award.

Scientists from Bristol Myers Squibb developed a method using supercritical fluid chromatography for chiral bioanalysis.

Supercritical fluid chromatography (SFC) has been optimized for the analysis of 5-, 10-, 15-, and 18-mer oligonucleotides (ONs) and evaluated for its effectiveness in separating impurities from ONs.

University of Innsbruck scientists recently used ultrahigh-performance supercritical fluid chromatography to facilitate the determination of anthraquinone derivatives in alder buckthorn.

In this article, we review some key considerations for chromatographic technique selection and method development across the full drug process—from early-stage active pharmaceutical ingredient (API) synthesis to routine commercial release activities.

Everyone is talking about sustainability, and organizations are creating sustainability programs. But what does green chemistry really mean, and how does it apply to gas chromatography?

Scientists from Peking Union Medical College & Chinese Academy of Medical Sciences created a new method for separating palonosetron hydrochloride, which is frequently used to prevent acute or delated nausea and vomiting caused by chemotherapy.

This review aims to provide a summary of the most current analytical techniques and their applications in per- and polyfluoroalkyl substances (PFAS) research, contributing to the ongoing efforts to monitor and mitigate PFAS contamination.

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Here is some of the most popular content posted on LCGC International this week.