Application Notes: General

A practical overview of the technique introduces the principles, instrumentation, and typical sample of workflows used in TD-GC-MS.

Poster showcasing Pfizer's use of ACD/Labs’ method development software to automate method variation simulations. Highlights key tools and features that streamline method transfer and boost efficiency through automation.

This poster presents an example of the analysis of all 17 explosives listed in EPA 8330B using atmospheric pressure chemical ionization liquid chromatography mass spectrometry (APCI-LC-MS/MS), which allowed for more sensitive and selective analysis than PDA detection. In addition, MRM analysis provides an extra layer of confirmation based on the unique fragmentation of each compound.

This poster presents a comprehensive, multi-approach data processing method for the analysis of non-targeted PFAS in both positive and negative ionization modes. Results show this three-pronged approach gave comprehensive identifications without excess false positives.

This poster shows the development and validation of a fully automated sample preparation and subsequent LC-MS/MS with trap-and-elute chromatography assay analyzing 25-hydroxyvitamin-D2 and D3. With this automated platform, technicians can significantly reduce their active time in the sample preparation workflow, focusing primarily on sample registration and results review.

EPA Method 1633A is currently the only validated multi-lab method for PFAS detection in leachate. This poster demonstrates the effectiveness of a system to provide robust, stable performance over 154 injections and 37 hours of continuous PFAS analysis, making it ideal for routine monitoring of complex leachate matrices.

With this AEX method a mix of six oligonucleotides can be separated in under two minutes.

New automated workflow enables fast comparison of chromatograms, revealing sample differences and simplifying essential oil quality control.

Cryogen-free TD–GC–MS method enables 10 ppt detection of ethylene oxide from fugitive sources, compliant with draft US EPA Method 327.

Cryogen-free TD–GC–MS method enables ppt-level analysis of 30 volatile fluorinated compounds released during PFAS destruction, compliant with US EPA OTM-50.

High-capacity sorptive extraction with GC–MS enables trace analysis of odorants and chlorophenols in water, combining ppt sensitivity with full automation.

Trap-enhanced SPME Arrow analysis improves aroma profiling in food, enabling better peak shape, greater analyte coverage, and a wider concentration range.

John Yates’ lab is using MOBILion’s Parallel Accumulation Mobility Aligned Fragmentation (PAMAF) technology to enhance the DeGlyPHER workflow, which enables detailed, site-specific analysis of N-glycosylation in viral spike proteins such as SARS-CoV-2. This method combines sequential deglycosylation with high-sensitivity LC-MS to quantify glycan occupancy and processing, offering insights into the relationship between glycosylation and immune response. DeGlyPHER has been applied to over 200 vaccine candidates, including those for HIV, influenza, and Ebola, advancing understanding of glycoprotein-based immunogen design. This executive summary explains how DeGlyPHER is transforming vaccine development in real time, driving progress toward more effective and consistent immunization strategies, and delivering a more sensitive and high-throughput approach compared to traditional glycoproteomic methods.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

This non-IP-RP method, using ammonium bicarbonate as mobile phase additive, is highly sensitive and suitable for the bioanalysis of therapeutic oligonucleotides.

This application with data from Roche Diagnostics confirms superior performance of bioinert-coated YMC Accura BioPro IEX SF columns for the IEX-MS analysis of mAbs.

Discover the supremacy of the bioinert coated hardware of YMC Accura BioPro IEX QF columns for reproducible analysis of oligonucleotides in ion-exchange chromatography.

This application note provides you an optimum RP method for the DAR determination of a site-specific ADC using a widepore YMC-Triart Bio C4 column.

This SEC-MS method demonstrates the precise separation of a single-chain variable fragment from its drug-conjugate.

With this AEX method a mix of six oligonucleotides can be separated in under two minutes.

Experience high recoveries from the first injection! YMC Accura BioPro IEX SF columns provide excellent peak shapes for the ion-exchange analysis of mAbs.

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent in plastic with accuracy and sensitivity, providing reliable and reproducible runs for high throughput laboratories.

Discover how the PerkinElmer GC 2400™ Platform provides fast analysis and high reproducibility.

Read how the integrated HS-GC workflow allows a continuous optimization of the pneumatic values for ultimate precision in GC retention time.

Discover an optimized GC/MS approach for SVOC in complex matrices.

Discover how the PerkinElmer GC 2400™ Platform helps improve resolution requirements.

Discover the GC 2400™ Platform for analytical precision and robustness for fuel alcohol analysis over a wide range of sample concentrations.