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Polymer Char ICPC User Training

ByLewis Botcherby

The Column

Polymer Char are holding a “User Training Meeting” at the 6th International Conference on Polyolefin Characterization (ICPC), Shanghai, China, 6–9 November 2016.

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Equine Drug Testing with LC–MS/MS

ByGesa J. Schad

The Column

Doping and cheating the competition may be as old as competition itself. Doping horses for chariot racing was reported during the Roman Empire and doping is now commonly reported in the press. Advanced technologies such as ultrahigh-pressure liquid chromatography (UHPLC) analysis coupled to ultrafast tandem mass spectrometry (MS/MS) detection provide excellent sensitivity for the analysis of horse doping agents.

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Applying LC with Low-Resolution MS/MS and Subsequent Library Search for Reliable Compound Identification in Systematic Toxicological Analysis

ByHerbert Oberacher,Florian Pitterl,Johanna Pitterle,Julia Steger,Sebastian Köb

LCGC Europe

Systematic toxicological analysis (STA) is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using non-targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification. Tandem mass spectrometry was performed on a low-resolution quadrupole-quadrupole-linear ion trap instrument. Acquired spectra were submitted to automated library search, and positive matches were verified by expert reviewing. After validation, the non-targeted LC–MS/MS technique was integrated in the STA service provided by our laboratory.

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Know Your Sample: Size Matters

ByDouglas E. Raynie

LCGC Europe

The past couple instalments of “Sample Preparation Perspectives” have looked at current trends in the field. Another recent trend is dried blood spot analysis and other analysis methods using minute sample amounts. This month we take a quick look at the role of sample homogeneity and the determination of sample size. Microsampling approaches, including dried blood spots, are discussed.

Company Profiles

LCGC Europe

A selection of profiles on leading separation science companies.

Innovating Microfluidic Technologies

LCGC North America

The future of biological and clinical research will depend on technological innovations and cross discipline cooperation as science seeks a deeper understanding of increasingly complex biological systems. The 2016 recipient of the AES Mid-Career Award, Amy Herr, and her team at the University of California Berkeley have explored these areas using a combination of chemical engineering, mechanical engineering, and electrical engineering with strong foundations in biology, material science, and analytical chemistry to innovate new microfluidic analytical technology. She recently spoke to LCGC about this work.

Perchlorate Analysis by IC: Water Impact

BySponsor's Content

Sponsored Content

Continuing MilliporeSigma’s series of podcasts on the impact of water quality on chromatography techniques, Joe Plurad discusses the practical effects of ultrapure water in a specific area of analysis: The importance of water quality on perchlorate analysis by ion chromatography (IC).