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Ultra high resolution, accurate mass (UHRAM) mass spectrometry, based on the Thermo ScientificTM OrbitrapTM technology, is a powerful new approach to high throughput screening and quantitation in complex sample matrices. To learn more about how UHRAM is used in the Million Metabolome Project, an ambitious milestone for Exposome Research, LCGC talked with Dean Jones of Emory University.

Webster’s New Collegiate Dictionary defines a myth as “an ill-founded belief held uncritically, especially by an interested group.” Could that group be misinformed chromatographers? Find out by clicking through the slideshow.

Temperature affects not only retention but also relative retention in gas chromatography (GC) and therefore, when we change temperature, we also change the selectivity of the separation. This is true as we alter the isothermal separation temperature, but also as we change the slope of the temperature program gradient.

Incognito has witnessed the rise of biochromatography and it looks exciting!

A new study hopes to highlight that poison was used as far back as 30,000 years ago. Dr Valentina Borgia, a specialist in Palaeolithic hunting weapons and Marie Curie Fellow at the McDonald Institute for Archaeological Research at the University of Cambridge, is using liquid chromatography combined with mass spectrometry (LC–MS) to analyze prehistoric weaponry.

Scientists have published a novel method to detect multiple celiac disease-epitopes in wheat extracts simultaneously using liquid chromatography–multiple reaction monitoring mass spectrometry (LC–MRM–MS).

Methadone, a drug prescribed for managing the symptoms of heroin withdrawal and chronic pain, has been linked to the formation of the carcinogenic compound N-Nitrosodimethylamine (NDMA) in drinking water. Understanding which compounds contribute to NDMA formation in water could lead to tailored wastewater treatment approaches to remove the risk of contamination.

Novasep (Pompey, France) has signed two partnership agreements with Allied Laboratories (Kobe, Japan) and AR Brown (Tokyo, Japan) to extend its presence in Japan.

Anthias Consulting (Cambridgeshire, UK) is celebrating 10 years since it was founded in June 2005.

Click the title above to open The Column June 19, 2015 Europe & Asia issue, Volume 11, Number 11, in an interactive PDF format.

Click the title above to open The Column June 19, 2015 North American issue, Volume 11, Number 11, in an interactive PDF format.

Marine polychaetes are a common type of annelid worm widely spread in marine environments. Raquel Fernandez, University of Copenhagan, spoke to LCGC about her innovative approach to developing an untargeted method to monitor polychaetes and assess their potential use in environmental monitoring of oil spills.

Two antibody samples were characterized using column calibration and multi-detection SEC, and the results compared to show how multi-detection SEC provides more accurate data and a more complete characterization of the protein mixtures under study.

This application note demonstrates how LECO’s Pegasus® GC-HRT paired with its unique ChromaTOF-HRT® brand software, gives users the means to confidently identify “known unknowns” and “unknown unknowns” in swimming pool and hot tub water.

HPLC 2015 Monday Morning Sessions

HPLC 2015 Monday Afternoon Sessions

HPLC2015 Tuesday Afternoon Sessions

HPLC 2015 Wednesday Afternoon Sessions

HPLC 2015 Tuesday Morning Sessions

HPLC2015 Wednesday Morning Sessions

Once you have mastered the terminology and symbology the actual mathematics for the models and approaches used at the level which is useful to practicing analytical chemists is really very straightforward indeed.

The numerous advantages of translating gradient chromatographic methods between the differing formats of LC have been explored and discussed. While translations in principle obey well defined chromatographic theories, the authors investigate a number of potential pitfalls that may result in poor translations as exhibited by selectivity differences, changes in efficiency, and hence failure to meet resolution system suitability criteria.

The use of superficially porous particles (SPPs) in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology. At the recent Pittcon conference in New Orleans, Louisiana, USA, a large number of oral and poster presentations centred on the current research and advances using superficially porous particles. This instalment aims to provide some highlights of these recent trends.

To characterize biopharmaceuticals, particularly monoclonal antibodies and antibody–drug conjugates (ADCs), you need a complete toolbox of powerful tools. You are probably familiar with LC–MS methods. But have you seen what light-scattering detection can do?

Using GPC/SEC for Excipient Characterization

A look to the upcoming symposium on the Recent Developments in Pharmaceutical Analysis (RDPA 2015), which will be held 28 June to 1 July 2015 in Perugia, Italy.

A novel microdestructive capillary electrophoresis (CE) method for the analysis of blue pen ink strokes has been published. The analysis of pen inks can be challenging because ink compositions are usually under patent, the samples are small, and inks can degrade over time.