Biopharmaceuticals and Protein Analysis

Researchers from Texas A&M University presented a new N–H aziridination method designed to target carbon–carbon double bonds in nonpolar sterol lipids.

In a recent study, the research team introduces a new software tool for proteomic analysis that can analyze both ESI and MALDI mass spectral data.

The phenolic compounds of Chrysanthemum morifolium have recently been separated in a study meant to identify their medical benefits.

In a recent study, a new instrument configuration suggests an alternative method for investigating polypeptides.

Researchers in China studied a new process for measuring aberrant metabolites.

To further understand what role ion chromatography (IC) plays in urine analysis, scientists investigated urine pretreatment techniques and how IC systems are designed and developed to measure various chemicals.

HRPs, while vital to creating drugs meant to fight serious diseases, are very difficult to quantify. To streamline the process, a group of scientists used a new approach for analyzing HRPs using MSPE and HPLC-UV.

To gain a better understanding of phosphatidylinositols, scientists used different LC–MS/MS techniques to find classifications to use in identifying further species of Pls.

When used appropriately in RPLC, ion pairing agents can increase the separation and retention of charged analytes. But should they be explored in other modes of HPLC as well?

An overview of different approaches for the qualitative and quantitative analysis of polysorbates.

In this interview, we explore the significance of this groundbreaking technology and its impact on mass spectrometry with Aaron Robitaille, Director of Marketing for Mass Spectrometry at Thermo Fisher Scientific in San Jose, California.

During the North American Chemical Residue Workshop, scientists discussed predicting liquid chromatographic retention times to identify contaminants.

Researchers compare the separation efficiency of olefins and paraffins using stationary phases containing silver(I) ions in ionic liquid (IL) and polymeric ionic liquid (PIL) matrices for gas chromatography techniques.

Researchers have introduced a novel primary method utilizing gas chromatography–isotope dilution infrared spectrometry (GC–IDIR) for accurate peptide purity analysis.

Researchers have developed a robust method utilizing high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) to accurately quantify amino acids in plasma, making it a valuable tool for clinical diagnostics and research in amino acid metabolism.

Scientists from the Pacific Northwest National Laboratory are using high-resolution ion mobility spectrometry-mass spectrometry to identify unknown compounds.

Researchers have discovered that phospholipids form doubly charged lipid-metal ion complexes during electrospray ionization (ESI), providing valuable insights into the analysis of phospholipid structures.

A research team has developed a new approach for selecting precursor ions in tandem mass spectrometry (MS/MS) experiments called DiffN, which increases the likelihood of biomarker discovery and provides a promising tool for lipidomic analyses.

New research reports on the development of a groundbreaking strategy that utilizes metal oxide-nanochannel arrays as templates for the in-situ growth of metal-organic frameworks (MOFs), revolutionizing the field of protein isolation, offering promising potential for high-efficiency protein recovery from complex biological samples.

In Alejandro Cifuentes's keynote lecture at HPLC 2023, he discussed the research he and his team have done to explore how foodomics can be effective in combating Alzheimer's disease.

A new study reveals that real-time library searching significantly improves the structural characterization of glycerophospholipids and sphingomyelins, offering enhanced selectivity and comprehensive analysis. By utilizing real-time identifications to trigger targeted MSn analyses, researchers gain deeper insights into these crucial lipid species.

Researchers have discovered diacylglycerols as potent biomarkers for the rapid diagnosis of breast cancer, using mass spectrometry imaging. This breakthrough study offers new possibilities for improved intraoperative assessment and personalized treatment strategies.

Scientists have developed a breakthrough MDLC–MS method for in-depth characterization of charge variants in therapeutic antibodies. The innovative approach enables the detection and evaluation of rare charge variants, facilitating improved safety and efficacy in antibody development.

The development of a newly-designed Girard's reagent, HBP, as charged isobaric mass tags has enabled selective capture and sensitive detection of aldehyde metabolites. The LC–dNLS-MS/MS screening approach using this reagent has successfully facilitated the discovery of natural aldehydes and their profiling in complex samples.

A temperature-controlled cryogenic distillation and gas chromatography, atom trap measurement system is used for precise analysis of atmospheric 85Kr abundance. This advanced technology enables online monitoring with high sensitivity and reduced sample size requirements.