Biopharmaceuticals and Protein Analysis

Scientists from the Swedish university analyzed the different ways water and trifluoroacetic acid (TFA) affect peptides in sub- and supercritical fluid chromatography (SFC) separations.

Steven Ray Wilson and Hanne Røberg-Larsen of the University of Oslo recently discussed the practical application and advantages of their FDA-validated research to analyse small molecule drugs and their metabolites in organoid/organ-on-chip systems that serve as alternatives to animal models.

Mankind Research Centre scientists recently tested a new solid phase extraction (SPE)-based approach coupled with GC–MS for analyzing small molecule N–nitrosamine impurities in antitussive syrups.

Here are the top five articles published on LCGC International this week.

University of Campinas and Iowa State University scientists recently combined vacuum-assisted sorbent extraction (VASE) and gas chromatography-mass spectrometry (GC–MS) to determine polycyclic aromatic hydrocarbons in açaí-based food products.

Dalian Maritime University scientists recently used high-performance liquid chromatography tandem triple quadrupole mass spectrometry HPLC-MS/MS to help detect amphetamine-type drugs in water.

Scientists from Università Politecnica delle Marche reported on baseline separation of isotopologoues of some amphetamine (AMP) derivatives on achiral and polysaccharide-based chiral columns.

Here are the top five articles published on LCGC International this week.

Navin Rauniyar and Xuemei Han of Tanvex Biopharma USA recently discussed how identifying product-related variants through characterization enables the recognition of impurities that compromise the quality and safety of drugs.

Shaanxi University of Technology scientists recently used analytical techniques including gas chromatography to identify various volatile organic compounds (VOCs) in different types of Chinese bacon.

Scientists from the Zheijiang University of Technology published a review article on the extraction of terpenoids from essential oils to determine what techniques can optimize enantiomer separation.

This article describes a comprehensive study on optimizing ion-pair reversed-phase liquid chromatography for analysing protected and unprotected single-stranded DNA oligonucleotides.

This article explores three case studies where autosampler injection programs help to (i) reduce the carry-over observed for large nucleic acids during anion-exchange chromatography (AEX), (ii) reduce peak distortion and breakthrough for monoclonal antibodies (mAbs) during hydrophilic-interaction chromatography (HILIC), and (iii) facilitate dissolution of lipid nanoparticles (LNPs) so that a size-exclusion chromatography (SEC) method can be applied for ribonucleic acid (RNA) payload analysis.

In biotherapeutics manufacturing, controlling size variants of therapeutic monoclonal antibodies (mAbs) is critical for ensuring product quality.

Scientists from Naif Arab University recently used a new approach to protect amide-based synthetic cannabinoids from degradation and esterification during GC–MS analysis.

Here are the top five articles that the editors of LCGC International published this week.

Scientists from the University of Geneva in Geneva, Switzerland and AstraZeneca in Mölndal analyzed how HILIC is related to the connections between oligonucleotide structures and diastereomer separation.

LCGC International spoke with Quang-Dong Bui, a second-year PhD student at Vrije Universiteit Brussels to discuss his work in oligonucleotide analysis.

University of Tübingen scientists recently tested a new approach to hydrophilic-interaction chromatography (HILIC) to address retention time repeatability issues.

Scientists from Roche Diagnostics in Germany are testing a new liquid chromatography (LC)-based approach for advancing process analytical technology (PAT) in biopharmaceutical processing.

The editors of BioPharm International spoke with Christine Rozanas, PhD, global product marketing manager at Cytiva, to discuss the advantages and persistent challenges with implementing continuous downstream chromatography.

Scientists from the University of Isfahan in Iran recently developed a new system for detecting and quantifying B vitamins in human samples.

Scientists from Hebei Medical University developed a sensitive liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for analyzing free fatty acids in human serum.

Scientists from the University of Edinburgh evaluated different polishing chromatography elution strategies to optimize output.

LCGC International sat down with Kemi Osho of the University of Nevada, Reno (UNR) to discuss her career and work with the Females in Mass Spectrometry (FeMS) group.