Gas Chromatography (GC)

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Electronic cigarettes and bottles with vape liquid on black background | Image Credit: © makcoud - stock.adobe.com

A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.

hand work and start Gas Chromatography Analyzer in laboratory | Image Credit: © Tanewpix4289 - stock.adobe.com

Element Materials Technology introduced its Rapid Response Pharmaceutical Testing Service, providing expedited testing and focusing on various requirements including active ingredients and final drug products, extractables and leachables, degradation production, and elemental impurities.

In this edition of “Inside the Laboratory,” Emanuela Gionfriddo, PhD, an associate professor of chemistry at the University at Buffalo, discusses her group’s current research endeavors, including using solid-phase microextraction (SPME) coupled to liquid chromatography (LC) and gas chromatography (GC) to further understand the chemical relationship between environmental exposure and disease and elucidate micropollutants fate in the environment and biological systems.

Kevin Schug, the Shimadzu Distinguished Professor of Analytical Chemistry at The University of Texas at Arlington (UTA). Photo Credit: © Kevin Schug

In this edition of “Inside the Laboratory,” Kevin Schug, PhD, a full professor of chemistry at the University of Texas at Arlington, discusses his laboratory’s group work in environmental monitoring around water and soil quality near oil and gas extraction, using techniques such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and coupling these techniques with mass spectrometry (MS).

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Researchers from Austria, Greece, and Italy conducted a study to analyze volatile organic compounds (VOCs) present in Irish and Scotch whiskys using solid-phase microextraction (SPME) Arrow with comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC–MS) to examine the organoleptic characteristics that influence the taste of spirits.

Top view of vials are arranged in the auto sampler for GC chromatography in laboratory with microscope testing background | Image Credit: © Anchalee - stock.adobe.com.

In this installment, we examine several of the common parameters that can affect automated peak integration and the resulting peak areas. We will consider how the data system detects the beginning and end of the peak, how it determines the peak maximum, how real peaks are differentiated from noise, and how signals at individual time intervals are summed to generate the peak area.