April 26th 2024
At issue in this study was the certified value of decabromodiphenyl ether (BDE 209) in a polystyrene matrix CRM relative to its regulated value in the EU Restriction of Hazardous Substances Directive.
Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS
December 1st 2021This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.
The LCGC Blog: ACS SCSC: What We Do and Who We Are
November 30th 2021In this month’s blog, we provide information about the Subdivision on Chromatography and Separations Chemistry (SCSC) of the Analytical Division of the American Chemical Society (ACS), sharing our main goals and introducing our newly appointed executive board members.
Enhancing Flame Ionization Detector Capabilities with Post-Column Reaction
June 1st 2021The incorporation of a post-column reaction using a 3D-printed, two-stage microreactor is showing groundbreaking performance improvements for flame ionization detection in many gas chromatography applications—and delivers carbon universal response.
HS-GC analysis is presented as an excellent method for the analysis of high volatile components in e-liquids. For the analysis of semivolatile ingredients, an additional sample preparation step is proposed based on a LLE followed by a freeze-out of the matrix components.
Effects of Water on Adsorbents in Porous Layer Open Tubular (PLOT) Column Gas Chromatography (GC)
June 1st 2021Solid adsorbent gas chromatography (GC) columns, such as porous layer open tubular (PLOT) columns, are the best option for GC analysis of C1–C5 hydrocarbons, but water can affect retention and selectivity. We review the effects of water for different types of PLOT columns, and explain how to prevent or remediate the problem.
Going Low: Understanding Limit of Detection in Gas Chromatography
May 17th 2021A review of the history and fundamentals for determining and reporting limit of detection (LOD) for analytical instruments and methods. Includes a discussion of the International Union of Pure and Applied Chemistry (IUPAC) and propagation of errors methods used for calculating LOD, and explains the limitations of the IUPAC method in modern chromatography.
Decomposing animal tissue releases volatile organic compounds (VOCs), of interest in forensic science. We describe the use of GC×GC–qMS/FID retrofitted with a reverse fill/flush (RFF) flow modulator for analyzing these VOCs in a tropical climate.
Going Low: Understanding Limit of Detection in Gas Chromatography (GC)
May 1st 2021The limit of detection (LOD) of an analytical method may be defined as the smallest concentration of analyte that has a signal significantly greater than that of a blank sample signal. We explore the sources of experimental uncertainty and variability in LOD determinations.
Identification of Microplastics in Environmental Monitoring Using Pyrolysis–GC–MS Analysis
April 7th 2021Pyrolysis–gas chromatography–mass spectrometry has advantages for the analysis of environmental microplastic samples compared to other leading analytical methods, including spectroscopic techniques.