HPLC

In order to improve LLOQ or LOD, or to increase precision in any case where S/N degrades precision, an increase in S/N will be beneficial. Here, John Dolan focuses on improvements in signal-to-noise.

The winners of LCGC's third annual awards were announced at Pittcon 2010.

Experimental data are presented to help understand HPLC column retention in a way that should make column selection and method development proceed faster when initial results with C18 columns are disappointing.

This article provides an introduction to electrochemical liquid chromatography mass spectrometry.

John Dolan examines some questions he recently received concerning the changes that took place in the 2009 edition of the United States Pharmacopoeia.

This month's installment of "Innovations in HPLC" discusses the use of HPLC for these recent threats to health and safety.

What should you do when a peak is too small or too large?

John Dolan looks at ways to get to the root of some of the most common problems encountered in the lab.

In the inaugural installment of his new column, LCGC veteran Michael Swartz provides an overview of some of the newer LC technology used in contemporary LC laboratories.

LCGC provides its annual editorial index as a resource for readers.

A fast clean and simple method to determine three organotin compounds in environmental samples is described

Kevin Schug talks to Harold McNair about his illustrious career in chromatography

Guest author Uwe Neue develops the principle of kinetic plots from scratch to make them more accessible to a wider audience.

The authors present the first installment in their examination of the basics of method validation.

In this installment of "Column Watch," Ron Majors looks at the results of a recent HPLC column survey conducted by LCGC North America.

The authors examine some critical factors with regard to buffers in LC and LC-MS research.

In Part II, we review MS ionization suppression; column, pH, and temperature selection; and system peaks and column equilibration issues associated with the use of five volatile perfluorocarboxylic acid reagents in LC.

To meet system suitability requirements, chromatographers might need to make adjustments to the high performance liquid chromatography (HPLC) operating conditions.

What's the best way to integrate a peak?

An optimization strategy to obtain the best possible performance in the shortest analysis time for comprehensive off-line 2D-LC.

This month's column discusses the type of problems one can encounter when using methods supplied to us by other.

Ron Majors provides first-hand coverage of some of the technology and application advances reported at HPLC 2009.

The former "Milestones in Chromatography" editor returns to give readers the story of his time in the field.

October 2006. The authors demonstrate the use of multiple-injection affinity capillary electrophoresis (MIACE) and several variations to MIACE to determine binding constants between the glycopeptide antibotics vancomycin, ristocetin, and teicoplanin from Streptomyces orientalis, Nocardia lurida, and Actinoplanes teichomyceticus, respectively, and D-Ala-D-Ala terminus peptides.

This is the fifth and final installment in a series of columns about various aspects of calibration of LC methods.