
Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.

Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.

Dafydd Milton of Thermo Fisher Scientific, Runcorn, Cheshire, UK talks about the analytical challenges facing the pharmaceutical industry and developments made to overcome them.

Microextraction by packed sorbent is a sample preparation technique that can be connected on-line with LC or GC systems.

In this study, the method of two-dimensional comprehensive GC applying an ultra fast quadrupole mass spectrometer as detector was used (GC×GCqMS).

Demonstrating that flow field-flow fractionation can separate protein aggregates for preparative and analytical purposes.

Demonstrating that flow field-flow fractionation can separate protein aggregates for preparative and analytical purposes.


Wyatt Application Note

Dionex Application note



An overview of high-throughput process development (HTPD) tools and approaches, as well as a case study


KNAUER Application Note

Glycoproteins appear to have become the most common biopharmaceutical product today, and they also seem to be increasing in popularity and importance with time.

Agilent Technologies has announced that Merck-Serono has selected the company?s OpenLAB ELN to enhance scientific collaboration globally throughout R&D for finding new small molecules and biopharmaceuticals.

A study of the protein absorption and binding regions has provided fresh insight into how this technique works, and could lead to better processes and cheaper drugs.

Why are many pharmaceutical companies outsourcing their chromatographic needs to contract research organizations?

Wyatt Technology Application Note

Dionex Application Note

The authors describe the most common cell-based protein expression systems and purification strategies used in the biotechnology industry.

The authors provide an introduction to the topic of biosimilars, review the available regulatory guidance, and discuss the various scientific challenges that are present.

Participants in this discussion are Richard Larsen of Agilent Technologies, Gary Dowthwaite of Biotage, Richard M. LeLacheur and Rohan Thakur of Taylor Technology, and Pat Bennett of Thermo Fisher Scientific.

In the first installment of LCGC's newest column, the authors address the topic of analytical biotechnology.

This article features some of the most frequently used HPLC applications for the characterization of biopharmaceuticals.