May 8th 2024
Scientists from the University of Messina recently developed a new omega-3 fatty acid-based supplement and tested its effectiveness on metabolism and lipid profiles.
Waters and Lambda Cooperate in Clinical Research
September 17th 2007Waters Corporation (Milford, Massachusetts) and Lambda Therapeutic Research Ltd (Mumbai, India) recently announced a joint cooperative agreement that provides innovative analytical laboratory equipment designed to enhance research quality service and business solutions for Lambda and its clients.
New Chromatographic Techniques for Pesticides and Antibiotics Analysis
September 17th 2007Science Daily, a website that features news revolving around the sciences, has published an article that describes new chromatographic techniques for the analysis of pesticides and antibiotics in food and beverage samples.
Nanostream Enters European Market with Opening of Sales and Support Office in The Netherlands
September 13th 2007Nanostream, provider of products and services that increase productivity in laboratories at pharmaceutical and biotech companies, extends its global reach to Europe by establishing a sales and support office in The Netherlands.
Routine Switching between High and Low pH on Xbridge HPLC Columns
September 1st 2007The effect of switching between high and low pH mobile phases on a single analytical HPLC column was investigated. The ability to rapidly switch between pH extremes on XBridge columns without special washing/re-equilibration steps dramatically reduces the time for separation of pharmaceutical compounds.
HPLC with Charged Aerosol Detection for Pharmaceutical Cleaning Validation
September 1st 2007Cleaning validation is a major analytical application in the pharmaceutical industry. Here, high performance liquid chromatography (HPLC) with charged aerosol detection is compared and contrasted to HPLC with UV detection showing comparable performance and several advantages for charged aerosol detection, especially for analytes that do not contain a chromophore.
High-Throughput Quantitative LC-MS-MS Assays by On-Line Extraction Using Monolithic Support
April 1st 2007LC-MS-MS has become a widely used technique for the fast and sensitive quantitation of small molecules. In this article, this approach has been extended to high-throughput quantitative LC-MS-MS analysis under GLP applications for a drug candidate in development from preclinical animal studies through clinical development.
Separation Instrumentation Demand
March 1st 2007Separation instrument techniques are among the most widely used technologies in the analytical instrumentation market. They span the entire industrial and regional marketplace. The lab separations market includes chromatographic techniques such as analytical and preparative HPLC, GC, IC, TLC, flash, and low pressure LC.
Supercritical Fluid Chromatography (SFC): A Review of Technical Developments
March 1st 2007In the mid 1980s the chromatographic application of gases compressed (or liquefied) to supercritical state was tested by research teams from several analytical instrument manufacturers. The recently introduced capillary columns seemed ideal candidates on which to perform such supercritical fluid chromatography (SFC) methods.
Facilitated Column Selection in Reversed-Phase Liquid Chromatography for Pharmaceutical Separations
This article gives an overview of the performance of a previously developed system for the ranking of C18 reversed-phase columns applied to different pharmaceutical analyses. The separation of eight different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid, clindamycin hydrochloride, buflomedil hydrochloride, chloramphenicol sodium succinate, phenoxymethylpenicillin and nimesulide was performed according to the corresponding European Pharmacopoeia monograph. The separations of dihydrostreptomycin sulphate and vancomycin were performed according to literature. It was found that that the column ranking system is a helpful tool in the selection of suitable columns in these analyses.
System Suitability and Validation for Chiral Purity Assays of Drug Substances
November 1st 2006Measurement of chiral purity is a necessary means of quality control for drug substances that exhibit chiral centers. This article describes a simple and practical approach to setting up system suitability and validation for chiral purity assays.
Market Profile: Dissolution Testing
October 1st 2006Dissolution testing is a mandatory test for the physical evaluation of solid dosage forms such as capsules, tablets, ointments, and creams. The most basic form of testing measures the rate of dissolution or solubility of a drug tablet. Dissolution testing also can be used in ADME and bioavailability studies, release rates of a drug substance under different conditions, as well as provide information as to the efficacy of in-vivo performance.
Top-Down versus Bottom-Up Approaches in Proteomics
September 1st 2006September 2006. Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."
Market Profile: Fast Liquid Chromatography
September 1st 2006The market for high performance liquid chromatography (HPLC) continues to be one of the most dynamic markets of the analytical instruments industry. A few years ago, the HPLC market began showing signs of maturity with little product innovation and slower growth rates. Although innovations in mass spectrometry (MS) helped to fuel growth, HPLC was an afterthought and considered to be a mere inlet to MS. However, the recent development of fast liquid chromatography (LC) systems is energizing the HPLC market.