Pharmaceutical Analysis

How the use of peptide standards can indicate control as well as provide guidelines for method development.

This article describes the optimum performance laminar chromatography technique and gives a brief account of recent applications in which it has been used.

Wehr discusses strategies for coupling LC and CE with MALDI–MS for use in proteomic studies.

Two solutions to the problem of obtaining quantitative information about protein expression are to couple two or more chromatographic modes to increase resolution and to use affinity selection techniques.

This column describes the principles of stir-bar sorptive extraction and presents some typical applications.

Tim Wehr looks at the requirements of multidimensional LC and provides examples of some systems used in proteomics.

Tim Wehr looks at the use of fast LC}MS for high-throughput analysis of pharmaceutical compounds.

Wehr defines 50 key terms that have come into common use in the era of genomics and proteomics.

This "CE Currents" column examines the use of capillary electrophoresis (CE) in three important areas of pharmaceutical analysis.

This month Tim Wehr discusses traditional approaches to protein characterization.

Wehr examines developments discussed at "CE in the Pharmaceutical Industry," a symposium sponsored by the California Separation Science Society.

In this first installment of this new column, editor Tim Wehr explores the evolution of drug discovery and the analytical challenges that lie ahead.

Krull and Swartz examine validating cleaning methods for pharmaceutical manufacturing equipment and look at general requirements and specific cleaning procedures, sampling types, and analytical methods.