Application Notes: General

This guide provides an overview of the Biozen size exclusion chromatography columns for the analysis of monoclonal antibodies, biosimilars, and other biomolecules.

The versatile selectivity and high temperature limit of Zebron ZB-624plus provides a one column GC-FID solution to cannabis residual solvent and terpenes testing.

An expanded list of 15 mycotoxins for LC–MS/MS analysis is shown with a simple solvent and modified QuEChERS salt extraction. The workflow is simple and accessible.

The California list covers a wide range of pesticides with diverse chemical properties. This LC–MS/MS method features increased resolving power for the multiresidue pesticides of interest.

Flash chromatography is widely used for purifications in pharmaceutical product synthesis and is now finding similar application in CBD -THC remediation.

Six nitrosamines are separated using a YMC-Triart C18 UHPLC column. This is challenging due to the commonly observed small peaks thanks to low impurity concentrations.

A practical GC-FID method for 20 terpenes from cannabis using a Zebron ZB-624PLUS GC column with an upper temperature limit of 300/320 °C.

CBG-A dominant cultivars show lower total THC concentrations compared to CBD-A dominant cultivars and are sought for their likelihood to pass total THC compliance testing.

A practical chromatographic separation of 18 cannabinoids with flexibility across HPLC and UHPLC platforms in a simple, isocratic workflow.

The complementary roles of dynamic headspace and sorptive extraction in the analysis of fragranced consumer products using TD–GC–MS 

Analysis of VOC and FOG emissions from automotive interior materials by direct desorption TD–GC–MS in accordance with VDA 278

An application note demonstrating the quantitative analysis of microplastics using direct thermal desorption (TD) combined with GC–MS

A study describing the advantages of using tube-based thermal desorption for monitoring chemical warfare agents at ultratrace levels

Application note discussing innovative cryogen-free ambient air monitoring in compliance with US EPA Method TO-15

Application describing the use of hydrogen carrier gas to enhance TD–GC–MS methods for semi- SVOCs in air: an illustration with polyaromatic hydrocarbons (PAHs)

Detailing how thermal desorption GC–MS can be used to monitor the release of PFAS during the application of aqueous film-forming foam

Automated cryogen-free monitoring of “air toxics” in ambient air using tube-based TD–GC–MS in accordance with US EPA Method TO‑17

This application demonstrates high-resolving, reproducible charge variant analysis of two monoclonal antibodies, trastuzumab and NIST mAb, with different pH gradients.

Providing guidance for optimizing the analytical performance of sorbent tube sampling and thermal desorption–GC–MS for disease diagnosis via breath and bio-monitoring.

The use of sub-2 µm particles for SEC have expanded analytical method for the characterization of biologics. This is especially noteworthy with monoclonal antibodies (mAbs), wherein methods developed on ultra high-performance SEC (UHP-SEC) columns can separate not only aggregates, but also fragment. This application note explores the effect of column internal diameter for robust size exclusion chromatography methods.