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Click the title above to open the Current Trends In Mass Spectrometry July 2020 special issue in an interactive PDF format.

In gas chromatography, heating the sample in the inlet can lead to sample losses and loss of quantitative reproducibility, but these problems can be avoided using cold sample introduction. Here, we explain the various types of cold injection and why you should consider it in your next instrument purchase or upgrade.

In this interview, Rafael Paseiro-Cerrato of the U.S. Food and Drug Administration discusses his investigations into the potential for compounds in can coatings to migrate into food.

Click the title above to open the LCGC Europe July 2020 regular issue, Volume 33, Number 7, in an interactive PDF format.

Are your OOS investigations scientifically sound and is the assignable cause correct? Or are OOS results invalidated using the ever-popular justification of analyst error?

In this study, a method for extraction and preconcentration of trace amounts of organophosphorus pesticides was developed using magnetic solid-phase extraction followed by HPLC with UV detection

As described in last month’s blog post, the ongoing global pandemic has transformed the way that educators approach teaching analytical chemistry. As I reflect back on my own experience from the Spring 2020 semester, one positive aspect that has come from the seemingly infinite number of video meetings has been the opportunity to connect with colleagues that we might not consider if it weren’t for the “new normal” of working remotely.

This is seventh in a series of articles exploring hot topics in high performance liquid chromatography (HPLC).

Click the title above to open The Column June 2020 Europe & Asia issue, Volume 16, Number 6, in an interactive PDF format.

Researchers from The Hong Kong Jockey Club, Sha Tin Racecourse, Hong Kong, China, have developed a comprehensive screening method for the detection of antipsychotics in horses, using LC–MS/MS.

Agilent Technologies Inc. has announced that biotech start-up Trilogy Sciences has been awarded an Agilent Golden Ticket at LabCentral, a leading biotech innovation hub based in Cambridge, Massachusetts,

From 10:00 to 11:30 am CDT today, six workshops are being held.

On Wednesday afternoon from 12:00 - 1:30 pm CDT, seven workshops will be presented. An Award Session (live webinar) will start at 1:45 pm with Richard A. Yost, presiding.

Today in the ASMS 2020 Reboot event, six workshops will be held, on mass spectral library searching, mult-omics research, celebrating women mass spectrometrists, machine learning, art and archeology, and a platform for quantitative mass spectrometry data.

On Thursday morning in the ASMS 2020 Reboot event, eight workshops will be held, on the NIH and NSF review and funding process, automated proteomics sample preparation, cannabis and hemp analysis, mass spectrometry research and education in the developing world, the proteomics standards initiative, MS for process analytical technology, career opportunities for Chinese scientists, and polymer architecture.

This afternoon in the ASMS 2020 Reboot event, seven workshops will be held, on ion-mobility mass spectrometry, building connections between primarily undergraduate institutions and R1 (doctoral) institutions, data-independent acquisition, multi-attribute methods, photoionization, the international lipidomics society, and top-down proteomics.

On Thursday afternoon in the ASMS 2020 Reboot event, seven workshops will be held, on ambient ionization, DMPK aspects of new therapeutic modalities, machine learning for MS data analysis, standardizing the MS workflow, leveraging emotional intelligence during the pandemic, the multidimensional clinical space, and large-scale data analysis and management.

To address the quest for greater separation power, the chromatographic community developed comprehensive two-dimensional liquid chromatography (LCxLC). But even with LCxLC, it can still be challenging to analyze highly complex samples and obtain accurate and correct information. In this article, opportunities for optimizing methods for extracting maximum information from one-dimensional (1D)-LC and two-dimensional (2D)-LC chromatographic data are explained.

Tuesday's conference highlights include two award presentations, workshops, a lunchtime trivia break, and corporate activities.

As our academic year comes to end, I always take time to reflect on what I have learned in the past year. As an assistant professor in Forensic Sciences and Chemistry at Chaminade University of Honolulu, I take the opportunity to review my courses regularly and implement new tools. Some of them will be successful and others will not.

On Friday morning in the ASMS 2020 Reboot event, from 10:00 to 11:30 am CDT, eight workshops will be held, on bioanalysis of oligonucleotides and peptides by triple quadrupole and high-resolution mass spectrometry, and methodologies and best practices for extractables and leachables testing.

Click the title above to open the LCGC North America June 2020 issue, Volume 38, Number 6, in an interactive PDF format.

Click the title above to open the LCGC Asia Pacific May/June 2020 regular issue, Vol 23, No 2, in an interactive PDF format.

Determining product shelf life is a regulatory requirement for pharmaceuticals and many other regulated consumer products. In this comprehensive overview of stability studies and testing, we summarize current regulatory requirements, share industry practices for forced degradation, and explain approaches for reduced testing and data evaluation to expedite stability study timelines.

Multidimensional separations, in which two or more separation methods are coupled, are a valuable analytical tool for higher peak capacity and improved selectivity for the analysis of complex samples like biotherapeutics.

Chromatography data systems (CDS) have been at the center of multiple FDA 483 citations and warning letters, with an emphasis on peak integration and interpretation of chromatograms. Here, we review the issues associated with ensuring compliance when performing peak integration.

COVID-19-related laboratory shutdowns are sure to cause a myriad of problems with liquid chromatography (LC) instrumentation across the globe. Taking a systematic approach to restarting these systems will save time and money in the long run, by preventing problems that may otherwise appear in days or weeks following startup.