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LCGC is proud to announce that Ryan T. Kelly is the winner of the 2020 HTC Innovation Award.

Click the title above to open the LCGC Asia Pacific February/March 2020 regular issue, Vol 23, No 1, in an interactive PDF format.

In this morning session, experts from both academic and industrial laboratories with substantial experience in two-dimensional liquid chromatography (2D-LC) will describe ways that 2D-LC is impacting their workflows for small- and large-molecule analysis, as well as developments in instrumentation, and optimization, and data analysis for 2D-LC.

In this afternoon session, recent developments in analytical chemistry approaches to ingredients used in beer, monitoring of the brewing process, and evaluation of beers are presented. The invited session, presided over by Bruce Hamper of the University of Missouri, St. Louis, will be held in Room 183B.

This morning session, which continues the conversations of Tuesday’s LCGC Award Symposium, focuses on new developments in analytical separations, particularly in pharmaceutical, environmental, and food and beverage analysis.

This morning’s networking sessions, taking place fro 10:30 am to noon, cover a range of techniques and topics.

The 2020 winners of the LCGC Lifetime Achievement and Emerging Leader Awards, Daniel W. Armstrong of the University of Texas at Arlington, and Szabolcs Fekete of the University of Geneva, will be honored in this Tuesday afternoon session, in room W183A.

This morning symposium, organized by the International Association of Environmental Analytical Chemistry (IAEAC), focuses on analytical solutions to address imminent and global grand challenges facing the environment.

Today’s networking sessions cover a range of techniques and topics.

This Monday morning session, in Room W181A, honors Ronald E. Majors, is the 2020 winner of the Dal Nogare Award, which is presented by the Chromatography Forum of the Delaware Valley.

Katelynn Perrault will receive the Satinder Ahuja Award for Young Investigators in Separation Science during a session that starts at 8:30 am in Room W181B.

This afternoon session takes place in Room W176C. Zack Gurard-Levin of SAMDI Tech, will kick off the session with a talk describing the combination of high-density biochip arrays presenting self-assembled monolayers (SAMS) of alkanethiolates on gold with matrix-assisted laser desorption ionization (MALDI) MS to create a technique, referred to as SAMDI.

Dr. Ziva Cooper of the University of California, Los Angeles, will present the plenary lecture this afternoon at 5:00 pm in the Skyline Ballroom at McCormick Place.

Click the title above to open the Current Trends In Mass Spectrometry March 2020 special issue in an interactive PDF format.

Click the title above to open the LCGC North America March 2020 issue, Volume 38, Number 3, in an interactive PDF format.

This review addresses recent ideas on the separation mechanism of HILIC, the advantages and disadvantages of the technique, and new applications.

Examination of audit trail entries is a key part of the second-person review. What do regulatory documents say about this topic, and how can we speed up review?

Our interview explores Dan Armstrong’s career of contributions, spanning enantiomeric separations, molecular recognition, ionic liquids, ordered media, mass spectrometry, drug development, environmental research, and food analysis.

Szabolcs Fekete tells us about his work characterizing therapeutic proteins, studying liquid chromatography column technology, and optimizing methods.

Analysis of the compositional variation in living cells is essential for understanding biological processes. Single-cell elemental analysis by triple-quadrupole ICP-MS is emerging as a selective, highly sensitive, and potentially high-throughput technique for the study of constitutive elements, and uptake of metallodrugs (or metal-containing nanomaterials) in single cells.

The presence of per- and polyfluoralkyl substances (PFAS) in water is an important health and environmental concern. Liquid chromatography–mass spectrometry (LC–MS) has been established as the most suitable technology for monitoring these substances. A method is described, using EPA 8327, for PFAS analysis in groundwater, surface water, and wastewater.

Drug discovery using high-throughput screening of discreet compounds, and the discovery of natural products with pharmacological mechanisms of action, rely on bioassay-guided fractionation analysis. Recent applications of affinity selection–mass spectrometry (AS-MS) are useful for exploring the discovery of ligands to membrane-bound proteins and RNA targets.

Food quality differences are dependent on botanical and geographical origins of primary food ingredients as well as storage and handling. Quality assessment for food materials, including cocoa and olive oil, is demonstrated by applying two-dimensional gas chromatography (GC×GC) combined with time-of-flight mass spectrometry (TOF-MS) and pattern recognition.

This instalment of “GC Connections” dives into temperature programming. First, the differences in peak widths and retention times between temperature programmed and isothermal chromatograms are examined. Why are all the peaks so sharp in temperature programmed GC, yet they get broader (and shorter) in isothermal GC? Next, we explore some early ideas about temperature programming and peak broadening that explain why the peaks are so sharp in temperature-programmed GC, and why the peak spacing is different from isothermal GC. Finally, we examine an important consequence of our ability to program temperature: the need for temperature programming in splitless and other injections that use “solvent effects” and other peak focusing mechanisms. These points are illustrated using several historical figures and chromatograms from the early days of GC.

This article presents possible uses of ion chromatography and related techniques combined with various detection methods for clinical and pharmaceutical analysis of common inorganic and organic anions and cations. An overview of achievements in this area from the past 10 years is presented and the most important trends and development perspectives for ion chromatography are described.

Isabelle Kohler from Leiden University, in Leiden, The Netherlands, spoke to LCGC Europe about the latest trends in clinical metabolomics using chromatography and how the field is likely to evolve in the future.

What concentration of aqueous buffer should I use in the mobile phase when developing a re-versed‑phase liquid chromatography (LC) method for the analysis of ionogenic compounds?

Nancy L. Allbritton of the University of Washington in Seattle is the 2020 winner of the Ralph N. Adams Award in Bioanalytical Chemistry, which is presented by the Pittsburgh Conference. The award recognizes significant contributions to the field of bioanalytical chemistry, broadly defined.