From ghost peaks to baseline interferences, analytical laboratories deal with several challenges in their everyday work. Tips for Addressing Common Problems with LC Analysis offers laboratories some practical advice for dealing with common analytical problems and suggests using ultrapure water is a key strategy.
Wouldn’t it be nice if a single generic high performance liquid chromatography (HPLC) method could be used for all small molecule drugs - not only for potency assays but also for ICH-compliant stability-indicating assays?
We have been working to develop the use of liquid chromatography–triple quadrupole–mass spectrometry (LC–MS/MS) for quantification of intact proteins from biological fluids.
From its development in 2016, the liquid-electron ionization (LEI) LC–MS interface has demonstrated a high versatility, offering the identification advantages of library-searchable, electron ionization (EI) spectra from samples in a liquid phase.
Click the title above to open the Current Trends In Mass Spectrometry May 2019 special issue in an interactive PDF format.
In this study of pesticides in spinach extract, the use of GC×GC–TOF-MS is demonstrated as a methodology to overcome matrix interferences and quickly quantify suspected contaminants. The approach also allows nontargeted analysis using a single sample injection.
For lurasidone treatment adherence testing, an untargeted high-resolution mass spectrometry method was employed, using known positive human urine samples to identify the lurasidone metabolites and their relative abundance in urine.
A novel mass spectrometry-based flavonoid profiling workflow is applied to characterize and structurally annotate a large number of unknown flavonoids in fruit juice and vegetable juice samples.
We present a brief preview of this year’s ASMS conference, taking place June 2–6, 2019, in Atlanta, Georgia.
Click the title above to open the LCGC North America May 2019 issue, Volume 37, Number 5, in an interactive PDF format.
In recent years, there has been a paradigm change in the way we approach mobile phase design for high performance liquid chromatography (HPLC). What are the trends?
Our annual report of sample preparation instrumentation, supplies, and accessories for gas and liquid chromatography
Decision trees offer great visuals to observe complex data sets and to classify data according to simple decision rules.
USP chapter can help ensure data integrity of a chromatography data system. Here’s how.
By optimizing and fully automating the bubble-in-drop microextraction process, this sample preparation technique, combined with gas chromatography–mass spectrometry (GC–MS) analysis, provides high precision and good figures of merit, as shown for selected organochlorine pesticides in the analysis of tap water and reservoir water samples.
Sometimes, the conditions specified in legacy liquid chromatography (LC) methods seem like they come from a different planet. This month, we look at which conditions to keep, and which ones to let go of.
“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography (GC) seen at Pittcon and other venues in the past 12 months.
This yearly report on new products introduced since March 2018 covers sample preparation instrumentation, supplies, and accessories.
Isabelle Kohler from Leiden University, in Leiden, The Netherlands, spoke to LCGC Europe about the latest trends in clinical metabolomics using chromatography and how the field is likely to evolve in the future.
Metabolomics 2019, the Jubilee 15th International Conference of the Metabolomics Society, will be held in The Hague, The Netherlands, from 23–27 June 2019. The conference will be held at the World Forum Conference Centre, located in the Hague, and an hour from Schiphol Airport and Rotterdam The Hague Airport.
In this excerpt from LCGC Europe’s e-learning platform, CHROMacademy.com, mobile phase design for high performance liquid chromatography (HPLC) is discussed.
An introduction from the guest editor of this special supplement from LCGC Europe revealing recent developments in high performance liquid chromatography (HPLC) and ultrahigh-pressure liquid chromatography (UHPLC).
This yearly report on new products introduced since March 2018 covers sample preparation instrumentation, supplies, and accessories.
Click the title above to open The Column November 07, 2017 Europe & Asia issue, Volume 13, Number 16, in an interactive PDF format.
The Association of British Spectroscopists (ABS) Trust invites applications for the 2020 Gordon Kirkbright Bursary and the 2020 Edward Steers Bursary.
The Chinese American Chromatography Association (CACA) presented awards its Young Investigator and the Student Excellence Awards at the CACA annual dinner event at Pittcon 2019 in Philadelphia, Pennsylvania.
Click the title above to open the LCGC Europe April 2019 regular issue, Vol 32, No 04, in an interactive PDF format.
To answer the question "Is there a good flow diagram I can use for GC method development?" please see below for our first attempt at something suitable, in the form of stepwise decision trees and flow diagrams.
This is the first in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2019 conference in Milan, Italy, from 16–20 June. In this preview, Davy Guillarme discusses multidimensional liquid chromatography approaches for the characterization of protein biopharmaceuticals.