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Click the title above to open the LCGC North America December Special Issue, Corporate Capabilities 2019, in an interactive PDF format.

Sample preparation is the most crucial step for the development of an analytical method. The main purpose of sample preparation is the extraction and preconcentration of the target analytes, as well as the removal of the matrix interferences, before their separation and determination. It is the most time consuming step that should be deliberately optimized to enhance extraction selectivity and detection capability. LLE and SPE, along with their variations, are usually applied for sample extraction and cleanup. MIPs can replace conventional sorbent materials in sample preparation techniques such as SPE, SMPE, and MSPD, offering increased selectivity over the target analytes. Attention is given in MISPE, which is mostly used to study MIP applications, as well as a commercially available technique.

Lloyd Snyder was one of perhaps ten “founding fathers” of high performance liquid chromatography (HPLC), with seminal publications in most areas, including adsorption (normal phase), reversed phase, isocratic, gradient, and preparative chromatography; plus solvent, temperature, and column selectivity. With nine books, several hundred publications, and an h-index of 83, he was one of the most widely cited chromatographers and received many of the most prestigious awards in separation science.

Click the title above to open the LCGC Europe December 2018 regular issue in an interactive PDF format.

The 48th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2019) will be held 16Ð20 June 2019 at the Milano-Bicocca University, Milan, Italy. This is the first time that this Symposium will be held in Italy.

The fundamental principles of UV detection

The fundamental principles of UV detection are explained, in a single page.

An ultraviolet (UV) detector signal can be an excellent source of clues for troubleshooting problems with your LC-even if you are using a mass spectrometer. We also share another good source of clues.

The 2019 ISCC and GCxGC Symposia, May 12–17, 2019, in Fort Worth, Texas, promise to provide an exciting and relevant venue for discussions of the latest developments in chromatography.

Click the title above to open The Column November 2018 European/Asia issue in an interactive PDF format.

Click the title above to open The Column November 2018 North American issue in an interactive PDF format.

Yinsheng Wang will receive the EAS Award for Outstanding Achievements in Mass Spectrometry at the Eastern Analytical Symposium (EAS)in Princeton, New Jersey, on November 13.

The EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry will be presented to Linda Baine McGown at the Eastern Analytical Symposium (EAS) on November 14 in Princeton, New Jersey.

Peak Scientific has partnered with Molecular Science Corporation to supply nitrogen gas generation systems on their first mobile laboratory aimed at rapidly expanding the cannabis testing and research sector.

Researchers from the Centro de Investigación y Estudios Avanzados de IPN, in Mérida, Mexico, have investigated the feeding habits of the whale shark (Rhincodon typus) in the Mexican Caribbean using GC–FID.

Researchers from the University of Almeria have developed a method for the classification of rum using HS-SPME-GC–MS.

Agilent Technologies has announced the appointment of Eric Gerber as the company’s new Senior Vice President of strategy and corporate development.

This article presents two case studies regarding the characterization of protein-DNA complexes using two complementary multi-angle light scattering (MALS) techniques, namely size-exclusion chromatography (SEC–MALS) to determine absolute molar mass of each component, and composition-gradient MALS (CG–MALS) to quantify stoichiometry and affinity at binding sites in solution.

The EAS Young Investigator Award will be presented to Kerri Pratt at the Eastern Analytical Symposium (EAS), in Princeton, New Jersey, on November 12.

The EAS Award for Outstanding Achievements in Separation Science will be presented to Christopher Poll at the Eastern Analytical Symposium (EAS)in Princeton, New Jersey, on November 12.

I think its fair to say that there has been a paradigm change in the way we approach mobile-phase design for HPLC in recent years.

Click the title above to open the LCGC Asia Pacific November 2018 regular issue in an interactive PDF format.

Comprehensive two-dimensional gas chromatography (GC×GC) offers significant improvement for volatile chemical separation. Selecting suitable first (1D) and second dimension (2D) columns normally requires consideration of the chemical composition of a sample. Replacing one of these dimensions with a two-column ensemble (for example, 1D1 + 1D2 for the 1D column), provided with a pressure tuning makeup gas between them, varies the relative retentions of compounds before the modulation step according to the junction pressure. This makes it possible to alter the apparent polarity of the 1D ensemble, and this alters peak positions in the 2D GC×GC space. This article presents an account of studies that suggest this offers potential for improved operation for a GC×GC laboratory.