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On Thursday afternoon in the ASMS 2020 Reboot event, seven workshops will be held, on ambient ionization, DMPK aspects of new therapeutic modalities, machine learning for MS data analysis, standardizing the MS workflow, leveraging emotional intelligence during the pandemic, the multidimensional clinical space, and large-scale data analysis and management.

To address the quest for greater separation power, the chromatographic community developed comprehensive two-dimensional liquid chromatography (LCxLC). But even with LCxLC, it can still be challenging to analyze highly complex samples and obtain accurate and correct information. In this article, opportunities for optimizing methods for extracting maximum information from one-dimensional (1D)-LC and two-dimensional (2D)-LC chromatographic data are explained.

Tuesday's conference highlights include two award presentations, workshops, a lunchtime trivia break, and corporate activities.

As our academic year comes to end, I always take time to reflect on what I have learned in the past year. As an assistant professor in Forensic Sciences and Chemistry at Chaminade University of Honolulu, I take the opportunity to review my courses regularly and implement new tools. Some of them will be successful and others will not.

On Friday morning in the ASMS 2020 Reboot event, from 10:00 to 11:30 am CDT, eight workshops will be held, on bioanalysis of oligonucleotides and peptides by triple quadrupole and high-resolution mass spectrometry, and methodologies and best practices for extractables and leachables testing.

Click the title above to open the LCGC North America June 2020 issue, Volume 38, Number 6, in an interactive PDF format.

Click the title above to open the LCGC Asia Pacific May/June 2020 regular issue, Vol 23, No 2, in an interactive PDF format.

Determining product shelf life is a regulatory requirement for pharmaceuticals and many other regulated consumer products. In this comprehensive overview of stability studies and testing, we summarize current regulatory requirements, share industry practices for forced degradation, and explain approaches for reduced testing and data evaluation to expedite stability study timelines.

Multidimensional separations, in which two or more separation methods are coupled, are a valuable analytical tool for higher peak capacity and improved selectivity for the analysis of complex samples like biotherapeutics.

COVID-19-related laboratory shutdowns are sure to cause a myriad of problems with liquid chromatography (LC) instrumentation across the globe. Taking a systematic approach to restarting these systems will save time and money in the long run, by preventing problems that may otherwise appear in days or weeks following startup.

This instalment is the first in a series of three white papers on stability studies and testing of pharmaceuticals, as well as the development and validation of stability-indicating high performance liquid chromatography (HPLC) methods. The series is co-authored by Kim Huynh-Ba, a subject-matter expert on stability testing and regulatory compliance, and Michael Dong, the columnist on “Perspectives in Modern HPLC”. This first instalment provides a comprehensive and updated overview of stability studies and testing of small molecule drugs, current regulatory requirements, and industry practices for forced degradation, as well as possible approaches for reduced testing and data evaluation to expedite stability study timelines.

This is sixth in a series of articles exploring hot topics in high performance liquid chromatography (HPLC).

This is fifth in a series of articles exploring hot topics in high performance liquid chromatography (HPLC).

Click the title above to open The Column May 2020 Europe & Asia issue, Volume 16, Number 5, in an interactive PDF format.

Click the title above to open The Column May 2020 North American issue, Volume 16, Number 5, in an interactive PDF format.

Agilent Technologies, Inc. has become a sponsor of My Green Lab, a nonprofit organization dedicated to improving the sustainability of scientific research.

Biocompatible LC systems are generally regarded to be chemically more inert than conventional HPLC systems. However, a study into the chromatographic behaviour of some classes of compounds analysed on these iron-free HPLC systems revealed issues typically associated with metal contamination.

When you’ve reached the top, where do you go next? In this instalment of the LCGC Blog, Kevin Schug explores prospects open to those of us at the pinnacle of our academic careers. Reflecting on his unique journey and offering his perspective – from the stability of academic freedom to interesting research and outside opportunities – Kevin’s experience highlights several options.

My initial inclination was to write about something other than the current status of life, given the threats of coronavirus. However, after a month extension to the shelter-in-place was ordered by the U.S. government this past weekend, and after various e-discussions with friends and colleagues throughout the world who are experiencing similar challenges, I felt I might have something to offer to make life easier.

Click the title above to open the LCGC North America May 2020 issue, Volume 38, Number 5, in an interactive PDF format.

Click the title above to open the Current Trends In Mass Spectrometry May 2020 special issue in an interactive PDF format.

A preview of this year’s ASMS conference, in its new on-line format.

Click the title above to open the LCGC Europe May 2020 regular issue, Volume 33, Number 5, in an interactive PDF format.

One of the biggest failures with purchasing chromatograph systems and chromatography data system (CDS) software is either the total lack of or poorly written user requirements. So, how can you write acceptable requirements? Is specifying a chromatograph the same as software?

This yearly report on new products introduced in the preceding year, since May 2019, covers sample preparation instrumentation, supplies, and accessories.

Our annual review of the new sample preparation instrumentation products introduced in the past year.

Our annual review of new gas chromatography (GC) products introduced in the past 12 months.

How should you maintain the calibration and qualification of chromatographs during the COVID-19 pandemic? Here, we discuss the details of how to ensure data integrity of results when faced with travel limitations and requirements for social distancing.