December 5th 2023
Splitless modes of operation using an optimized pulse injection are described.
October 4th 2023
The impact of contamination on each part of the inlet is examined.
October 1st 2023
The author discusses the benefits and challenges of using hydrogen in the laboratory, specifically regarding gas chromatography and GC–MS procedures.
August 1st 2023
This instalment explores the challenges involved in detecting the effluent from a capillary gas chromatographic column and summarizes the many detector options.
Multi-Active Method (MAM) for the Analysis of Agriculture Product Technical Ingredients and Formulated Products
A collaborative multi-analyte method developed utilizes HPLC and UHPLC to analyze more than 70 active ingredients. This method offers a validated approach for determining technical AI alongside linearity, precision, accuracy, and specificity tests for seven active ingredients.
Green, Greener, Greenest—Sustainability at All Points of the Analytical Process
Mary Ellen McNally and Doug Raynie covered green chemistry and sustainable separations, from sample preparation through analysis with chromatographic techniques, at EAS 2023.
Review of Packed Sorbent Solid-Phase Extraction and Microextraction Methods From Manual to Automated
Studies published over the last five years have focused on fully or semi-automated approaches and their applications in extraction of both organic and inorganic pollutants, while modern robotic tools and 3D printing are starting to make impacts.
New LC–MS/MS Data Analysis Framework, MCnebula, Streamlines Untargeted Analysis
Researchers have introduced MCnebula, a new framework for untargeted LC–MS/MS data analysis. MCnebula focuses on critical chemical classes and utilizes visualization techniques to streamline the analysis process, enabling efficient pathway analysis, biomarker discovery, and classification of unknown compounds beyond the limits of spectral libraries.
Innovative Microvalve-Based Microfluidics Method for Electrically Driven Ion Transport in Microfluidic Systems
A new way to control ion transports in microfluidic systems has the potential to improve the technology and expand applications.
Shimadzu Opens Japanese Innovation Hub
With Shimadzu Corporation's new location, the company hopes to innovate their research and technological efforts.
Chromatographic Comparison of HILIC Stationary Phases Prepared Using Various Hydrophilization Techniques
This comparison of various silica-based HILIC stationary phases with different types of coatings provides a better understanding of how stationary phase selectivity can be influenced.
Insights into the Shape-Selective Retention Properties of Porous Graphitic Carbon Stationary Phases and Applicability for Polar Compounds
When the unique shape-selective properties of PGC are appropriately identified, PGC stationary phases can be harnessed for fine separations of structurally related compounds.
HPLC, MS, and CDS: The New Products to Watch—from Pittcon and Beyond
An examination of the new high performance liquid chromatography (HPLC), mass spectrometry (MS), chromatography data systems (CDS), and related products that were introduced over the last year.
Exploring Artificial Intelligence in Analytical Chemistry
Given that artificial intelligence (AI) seems to be on everyone’s mind, it’s worth pausing to look at how AI works, and how it can fit into analytical chemistry.
Tips & Tricks: Treating Your GPC/SEC System Properly
This installment of Tips & Tricks will provide some helpful pointers to keep
your GPC/SEC system in good shape.
Tools for Investigating the Expanding Per- and Polyfluoroalkyl Substances (PFAS) Universe
With suspect PFAS screening becoming more popular, and the list of known PFAS now in the thousands, novel analytical tools are needed to generate transferable data sets. We highlight key updates here.
Minimizing the Risk of Missing Critical Sample Information by Using Two-Dimensional Liquid Chromatography
Online 2D-LC is a powerful—and accessible—tool for analyzing pharmaceutical and biopharmaceutical samples, in both R&D and QC. It’s now easier than ever to develop 2D-LC methods, and they can be run in a fully automated manner.
Curing My Personal Ignorance, One Day at a Time
Is the informing power of separation science without limits?
Liquid Chromatography Column Design and Dimensional Analysis of the van Deemter Equation
The fundamental mechanisms of band broadening are usually introduced to students through the van Deemter equation. Dimensional analysis of this equation can give physical meaning to the equation coefficients and enhance our understanding relative to qualitative descriptions. This approach can also guide improvements to future liquid chromatography (LC) column designs.
Let’s Get Small: Miniaturizing Separations for Single-Cell Analysis
Further miniaturization of separations will greatly extend the reach of single-cell proteomics, metabolomics, and lipidomics, but key challenges in instrumentation, column technology, and ionization sources must be addressed.
Incorporating HPLC as a Multi-Attribute Characterization Technology for Next-Generation Drug Development
This paper provides an overview of some current and emerging physicochemical analytical challenges associated with these sophisticated drug systems and some of the technical advances needed in chromatographic systems to enable their design, development, and manufacture.
Development of a System Suitability Test for Two-Dimensional Liquid Chromatography
As two-dimensional liquid chromatography (2D-LC) becomes more widely used, system suitability tests (SSTs) become even more important.
Improved Performance of UHPLC–MS Hyphenated Systems
With a new prototype, we explore how to improve the resolution power and usability of LC–MS instruments for routine analysis in pharmaceutical applications.
The Crucial Step in Every Analytical Workflow: Sample Preparation—Are We Ready For a Growing Area of Intact Protein Analysis?
New sample preparation workflows for intact proteins in biological matrices are needed. We hope that others will join in this important field of research.
Paul Bohn Receives SEAC Charles N. Reilley Award
Paul Bohn, the Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering at the University of Notre Dame, is the 2022 recipient of the Society for Electroanalytical Chemistry (SEAC) Charles N. Reilley Award.
New Gas Chromatography Products for 2021–2022
Our annual review of new gas chromatography products.
New HPLC, MS, and CDS Products Introduced in 2021–2022: A Brief Review
Our annual review of new high performance liquid chromatography instruments, mass spectrometry systems, and data processing software.
Laboratory Accreditation Is Not a Cloak of Infallibility
Reviewing your contract laboratory’s QA/QC protocols can reveal much about the accuracy of the data the lab generates. Here is what to look for.
The LCGC Blog: Mentorship in the Time of COVID-19: Finding the Silver Lining and Announcing ACS SCSC Initiatives
An undeniable effect of the COVID-19 pandemic is that we have learned how to adapt (quickly) to sudden changes.
Exploring the Implementation of Compact Chromatographic Instrumentation in Common Analytical Workflows
Compact instrumentation offers important advantages for many workflows, as illustrated by these examples.
The LCGC Blog: The Beauty of the Quadrupole Mass Analyzer
The quadrupole mass analyzing device is now accessible to many analytical chemists as a detector in either HPLC or GC instruments due to their increasingly accessible price point. While it’s not vital that we understand the working principle of these detectors, insight into their design and operation can help enormously when planning or optimizing analyses or troubleshooting issues.
Controlling Retention Time Drift in Industrial Chromatography Settings
Computer-enabled technology approaches can mitigate the impact of aging instruments and instrument differences—leading to more robust, lower-maintenance analysis in industrial settings.
The LCGC Blog: Controlling Retention Time Drift in Industrial Chromatography
Everyone who is reading this column is interested in chromatography, and I want to shine a light on the industrial side of the application space.
New Sample Preparation Products and Accessories for 2017
This yearly report on new products introduced at Pittcon 2017 (or in the preceding year) covers sample preparation instrumentation, supplies, and accessories.
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