Analytical Instrumentation

A new chromatography-based approach was created to screen perfumes for hazardous substances.

Many multi-column gas chromatography systems use two-position multi-port switching valves, which can suffer from delays in valve switching. Shimadzu researchers aimed to create a new sampling and switching module for these systems.

In this installment of “LC Troubleshooting,” Dwight Stoll touches on highlights from Pittcon 2025 talks, as well as troubleshooting advice distilled from a lifetime of work in separation science by LCGC Award winner Christopher Pohl.

Iowa State University researchers evaluated imidazolium-based ZILs with sulfonate and triflimide anions to understand the influence of ZILs’ chemical structures on polar analyte separation.

The researchers explored ways to simplify retention time calculation across LC–MS and various other chromatographic methods.

A new type of micro-gas chromatography column was fabricated using direct metal laser sintering (DMLS) to circumvent manufacturing issues faced by other micro-GC systems.

Hydrophobic deep eutectic solvents have proven useful in extracting non-polar target compounds, though researchers have shown there is room for further development.

New types of smart proteolytic samplers were tested for their effectiveness in liquid chromatography-mass spectrometry (LC–MS)-based protein quantification.

The company announced multiple new product releases including a series of compact gas chromatography systems, three UV-Vis spectrophotometers, a new line of triple quadrupole mass spectrometers, and more.

The new benchtop encloser can be equipped with interchangeable onboard air filtration options to protect samples from contamination or reduce user exposure to harmful chemical gases.

University College London scientists recently created a new technique for selecting two-dimensional liquid chromatography (2D-LC) columns.

Waters Corporation recently announced two new columns to their MaxPeak Premier Reversed-Phase Column portfolio during the conference in Washington, DC.

Here is some of the most popular content posted on LCGC International this week.

In this edition of “Inside the Laboratory,” Jillian Goldfarb of Cornell University discusses her laboratory’s work with using gas chromatography–mass spectrometry (GC–MS) to characterize compounds present in biofuels.

Researchers from Bristol Myers Squibb and Sanofi recently tested a new means of using hydrophobic interaction chromatography (HIC) for removing impurities in monoclonal antibodies (mAbs).

This paper describes the content of a well-written analytical procedure for regulated high-performance liquid chromatography (HPLC) testing. A stability-indicating HPLC assay for a drug product illustrates the required components for regulatory compliance, including additional parameters to expedite a laboratory analyst’s execution.

The article discusses the application of a hybrid organic/inorganic surface technology that forms a barrier between the sample and the metal surfaces of both the HPLC system and chromatographic column. Formed by a vapor deposition of an ethylene-bridged siloxane polymer on metal substrates), this technology effectively addresses common chromatographic challenges such as analyte loss, carryover, and peak tailing due to metal-analyte interactions. It improves peak symmetry and areas, as well as reproducibility, thereby not only benefiting challenging analytes but also increasing confidence in analytical results. We demonstrate the benefits of this technology through the analysis of B-group vitamins, steviol glycosides, and dextran oligosaccharides typically found in food, beverages, and dietary supplements, showcasing its critical role in improving chromatographic performance.

In this column, we look at the current version and the update of USP <621> on high-performance liquid chromatography (HPLC) that becomes effective 1st May 2025.

At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Brett Paull from the University of Tasmania and HyTECH about his talk entitled: “Analytical Performance and Disruptive Potential of Fully Portable Portable and Field Deployable LC–MS Technology.”

Are you a chromatographer or a chromatography user?

In this edition of "The LCGC Blog," Jonathan Shackman discusses the differences between chromatographers and chromatography users, as well as advancements that have made chromatography a more accessible field.

A group of Malaysian and American scientists recently analyzed the benefits of using green metrics for detecting emerging contaminants (ECs) using analytical methods.

Splitless modes of operation using an optimized pulse injection are described.

A collaborative multi-analyte method developed utilizes HPLC and UHPLC to analyze more than 70 active ingredients. This method offers a validated approach for determining technical AI alongside linearity, precision, accuracy, and specificity tests for seven active ingredients.

Mary Ellen McNally and Doug Raynie covered green chemistry and sustainable separations, from sample preparation through analysis with chromatographic techniques, at EAS 2023.