Mass Spectrometry

Webinar Date/Time: Airing 1: Tuesday March 14, 2023 at 9am EST | 2pm GMT | 3pm CET Airing 2: Tuesday March 14, 2023 at 2pm EST | 1pm CST | 11am PST

Webinar Date/Time: Thu, Mar 2, 2023 11:00 AM EST

In this study, a probe electrospray ionization coupled to mass spectrometry (PESI-MS) method for ultra-rapid determination of MtF in plasma by isotope dilution was developed.

Webinar Date/Time: Tuesday, February 21st, 2023 Morning session: 9:30 am EST - 12:15 pm EST Afternoon session: 2:00 pm EST - 4:00 pm EST Wednesday, February 22nd, 2023 Morning session: 9:30 am EST - 12:15 pm EST Afternoon session: 2:00 pm EST - 4:00 pm EST

A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.

Webinar Date/Time: Monday, March 27th at 11am EDT|8am PDT|4pm BST|5pm CEST

Webinar Date/Time: Airing 1: Tuesday January 17, 2023 at 9am EST | 2pm GMT | 3pm CET Airing 2: Tuesday January 17, 2023 at 2pm EST | 1pm CST | 11am PST

This month we interview Raviraj Chandrakant Shinde from India, about his work on the analysis of various food contaminants using chromatography and mass spectrometry, and the challenges involved in analyzing polar and ionic pesticides.

This review article summarizes the results obtained from the combined efforts of a joint academic and industrial initiative to solve the real-life challenge of determining low levels of peptide-related impurities in the presence of the related biologically-active peptide at a high concentration.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Webinar Date/Time: Monday, November 28 2022 at 11 am EDT

How to lower the limits of quantitation as the regulatory landscape continues to evolve.

Non-targeted analysis of small molecules with ambient ionization mass spectrometry (AI-MS) is enabled by new mass spectral libraries and algorithms, such as the inverted library search algorithm (ILSA) developed at NIST.

Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.

Gene therapy vectors in the gigadalton (GDa) regime are beyond the range of conventional mass spectrometry. Charge-detection MS overcomes this limitation.

Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.

In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.

An overview of modern approaches to small-molecule drug discovery.

Better sample preparation and miniaturized separations are enhancing these analyses.

Sample preparation and analysis of pharmaceuticals in wastewater present unique challenges. Here, we describe those challenges.

The recruitment of young, talented entrepreneurs within academia and industry is needed to tackle many of the challenges that exist today and that will emerge tomorrow.

Further miniaturization of separations will greatly extend the reach of single-cell proteomics, metabolomics, and lipidomics, but key challenges in instrumentation, column technology, and ionization sources must be addressed.

Top-down mass spectrometry (TD-MS) of peptides and proteins results in product ions that can be correlated to the polypeptide sequence. Joseph Loo and colleagues at the University of California-Los Angeles (UCLA) have developed ClipMS, an algorithm assigning both terminal and internal fragments generated by TD-MS fragmentation, which can be used to locate various modifications on the protein sequence.

Ion mobility–mass spectrometry (IM–MS) has become a cornerstone of bioanalytical laboratories. New developments could lead to its widespread adoption for regulated bioanalysis methods such as anti-doping testing for anabolic steroids in athletes.

With the advent of ambient ionization and portable mass spectrometers, the ability to perform rapid, on-site analysis is fast becoming a reality. We review the critical recent developments enabling this capability as well as remaining challenges that must be tackled to enable widespread adoption.