Supercritical Fluid Chromatography (SFC)

This study delves into the challenges of online coupling, offering solutions to overcome peak distortion and enhance reliability in complex sample analysis. The resulting LC×SFC–MS/MS analysis allows differentiation of isomers in very complex samples, regardless of similar fragmentation patterns.

This article explores the use of chromatographic retention measurements in both LC and SFC to develop quantitative retention activity relationship (QRAR) models, offering a predictive tool for skin permeability without animal testing.

Separating stereoisomers is an extensively researched and challenging process, with approved substances being rare. A new SFC-based system was made to possibly ease some aspects of these procedures.

Shimadzu researchers aimed to develop a more efficient supercritical fluid chromatography method for solid-state injection and streamlining sample pretreatment.

This morning at Pittcon, The Chromatography Forum of Delaware Valley (CFDV) held an award session for the late Terry Berger, who was this year’s recipient of the Del Nogare Award.

Scientists from Bristol Myers Squibb developed a method using supercritical fluid chromatography for chiral bioanalysis.

Supercritical fluid chromatography (SFC) has been optimized for the analysis of 5-, 10-, 15-, and 18-mer oligonucleotides (ONs) and evaluated for its effectiveness in separating impurities from ONs.

University of Innsbruck scientists recently used ultrahigh-performance supercritical fluid chromatography to facilitate the determination of anthraquinone derivatives in alder buckthorn.

In this article, we review some key considerations for chromatographic technique selection and method development across the full drug process—from early-stage active pharmaceutical ingredient (API) synthesis to routine commercial release activities.

Everyone is talking about sustainability, and organizations are creating sustainability programs. But what does green chemistry really mean, and how does it apply to gas chromatography?

Scientists from Peking Union Medical College & Chinese Academy of Medical Sciences created a new method for separating palonosetron hydrochloride, which is frequently used to prevent acute or delated nausea and vomiting caused by chemotherapy.

This review aims to provide a summary of the most current analytical techniques and their applications in per- and polyfluoroalkyl substances (PFAS) research, contributing to the ongoing efforts to monitor and mitigate PFAS contamination.

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Here is some of the most popular content posted on LCGC International this week.

In this LCGC Blog, Kevin Schug discusses the potential machine learning has in helping predict physicochemical properties of molecules and optimizing chemical analysis processes.

Supercritical fluid extraction (SFE) was combined with supercritical fluid chromatography (SFC) hyphenated to mass spectrometry (MS) to analyze plastic additives that could be transferred into the environment from laboratory gloves.

Julien Crepier of TotalEnergies was one of the researchers that conducted this study, and he recently sat down with LCGC International to talk about his team’s findings.

Université d’Orleans and Chromisa Scientific scientists recently created a two-dimensional supercritical fluid chromatography (SFC) system with multiple heart-cutting (MHC) modes.

In this article, we review some key considerations for chromatographic technique selection and method development across the full drug process.

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Here is some of the most popular content posted on LCGC International this week.

Lausanne University Hospital scientists recently tested ultrahigh-performance supercritical fluid chromatography hyphenated to tandem mass spectrometry (UHPSFC–MS/MS) for detecting urinary endogeneous steroids.

Here are the top five articles published on LCGC International this week.

At HTC-18 in Leuven, LCGC International spoke to Claudio Brunelli about the evolution of supercritical fluid chromatography (SFC) techniques in the pharmaceutical industry.

Scientists from the Swedish university analyzed the different ways water and trifluoroacetic acid (TFA) affect peptides in sub- and supercritical fluid chromatography (SFC) separations.