Application Notes: General

Eliminating laborious sample preparation, field-flow fractionation greatly facilitates the absolute characterization of lignosulfonates by multi-angle light scattering.

• Background on capillary electrophoresis • Importance of glycan screening • Benefits of high-throughput screening with intuitive data analysis

One of the fundamental tenets of chromatography is the interaction between an analyte and stationary phase.

Plastics play a role in just about every market sector and research area including agriculture, food, packaging, pharmaceuticals, medical implants, and personal care products, making the potential leaching of additives like antioxidants or slip additives a major concern. In this article learn how the EDGE is able to extract additives from plastics in a fraction of the time of traditional techniques.

Analysis of paralytic shellfish toxins using a HPLC single step-gradient method with products of post-column derivatization detected using a fluorescence detector

Phenol formaldehyde resins (PFR) are used in various industrial products because of their versatile properties. Thermoplastic and thermo-reactive resin types differ in the degree of remaining reactive groups and their molar mass distribution (MMD). We compared the MMDs of two phenolic resins by gel permeation chromatography (GPC).

A simple 15-minute extraction method is all that is needed to quickly prep plastics for phthalate analysis.

A simple 15-minute extraction method is all that is needed to quickly prep plastics for phthalate analysis.

This application note shows the pyrolysis-GC×GC–HRMS profiles of crude oils for more detailed separations and more complete characterization of complex matrices, especially on the speciation of heteroatoms such as sulphur-containing compounds.

Chitosans are analyzed by SEC-MALS to determine molar mass moments and distributions.

Quantifies affinity, stoichiometry of biomolecular assemblies, helping understand the mechanism of interaction and develop therapeutics that target and modulate them.

Quantifies affinity, stoichiometry of biomolecular assemblies, helping understand the mechanism of interaction and develop therapeutics that target and modulate them.

The advantage of UV spectroscopy as an analytical method to detect protein aggregation is that it is non-destructive and uses low sample volumes, minimal sample preparation requirement and easy sample analysis. A quick QC method to indicate the presence of aggregation uses an Agilent Cary 60 UV-Vis spectrophotometer to identify aggregation of mAb solutions resulting from different stress conditions.

This study shows that the organic compounds giving rise to the flavor of beverages can be identified by high-capacity sorptive extraction using PDMS probes, wih analysis by thermal desorption–GC–MS.

Environmental laboratories analyze customer samples to determine the concentration of contaminants in soil, drinking water, and so on. Frequently these samples are diluted prior to analysis by the ICP-MS. It is critical that these dilutions are accurate and reproducible. In this study we compared the speed, accuracy, and consumable costs for common sample preparation techniques and found that the Microlab 600 is the best option.

Smaller particle size stationary phases have seen increased use in the modern analytical laboratory due to their ability to exhibit greater resolution while enabling the use of smaller column geometries. Shorter column lengths and narrower bores allow for faster run times and lower flow rates, decreasing laboratory costs in terms of solvent consumption and man-hours needed to run the analyses. This application note examines the effects of smaller particle sizes in various column geometries on size-exclusion chromatography (SEC) methods and the method variables affecting the characterization of antibody products.

This work focused on scaling-down a monoclonal antibody SEC method, starting with a typical analytical-size SEC column (YMC-Pack Diol 5um, 300Å, 300x8.0mm) and ending with a small particle, shorter length, narrower-bore column (YMC-pack Diol 2um, 300Å, 150x4.6mm). The purpose of this experiment was to detail the differing performance characteristics exhibited by each column as physical properties were altered, one variable at a time.

In the United States, the increasing acceptance of medical and recreational cannabis at the state level has created a need for accurate, precise and efficient analysis of cannabinoids in marijuana flower, extracts, and formulated products.

The poster describes how different suppressors (MSM and MCS) work and mentions possible applications.