Application Notes: General

Reflectron lenses are used in time-of-flight (TOF) mass spectrometers to create an electrostatic field to alter ion flow, providing for a longer flight path and therefore greater resolution.

Direct exposure probe (DEP) coupled to the Pegasus HT, time-of-flight mass spectrometer, was used for the identification of synthetic cannabinoids in MTN-series compounds.

Photonis has combined two of our superior detection and analysis technologies into a new digital ion beam profiling unit. The new Ion Beam Profiler combines a large microchannel plate (up to 120 mm) in a complete assembly with the Photonis Nocturn, a high-resolution digital CMOS low-light camera which is immune to sudden light damage.

Silica-based cyano stationary phases have historically exhibited poor stability and short column lifetime at pH extremes. This application note details an investigation of the stability of YMC's Cyano-HG (high strength) 10 ?m silica-based stationary phase, which was performed at a customer's request.

In water samples, OCPs are monitored by the U.S. Environmental Protection Agency by various methods including methods EPA 508, EPA 608, and EPA 8081. The use of solid phase extraction (SPE) can rapidly increase both extraction efficiency and reduce lab solvent usage. By implementing the FMS TurboTrace® ABN system with its dual cartridge functionality, an in-line Florisil cartridge can be added to perform automated extract clean-up during the elution step.

The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.

Natural and synthetic phenolic compounds have been used in a wide range of applications, from antiseptics and fungicides to food additives.

In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.

The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.

In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.

Wyatt Technology Corporation

Agilent Technologies Inc.

Polymicro Technologies, a subsidiary of Molex Inc.

PHOTONIS USA, Inc.

Polyimide coated fused silica capillary tubing is widely used in the separation sciences. In this application note, we share perspectives on modifying the internal surface of capillary tubing.

H2 is commonly used as GC carrier gas as the cost of He is increasing and its availability is decreasing. In addition to the cost/availability issues, H2 can provide more rapid separations at lower temperatures than He and provides longer column life. H2 gas is obtained by the electrolysis of water and many laboratories supply it to the GC via an in-house H2 generator.

Imtakt USA

PHOTONIS USA

The Hamilton PRP-C18 is a new column designed to provide high-efficiency reversed phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100 ?C), does not experience shrinkage or swelling and is completely inert to most conditions commonly encountered in reversed phase chromatography. In this study the pH stability of the PRP-C18 is evaluated. Even after prolonged exposure to concentrated (1 molar) NaOH and H2SO4 there was no measurable deterioration in performance.

Hamilton Company

Proton OnSite

Ion mobility spectrometry (IMS) has become widely accepted for the detection of chemical warfare agents, explosives, and narcotics as well as for pharmaceutical quality control and pesticide screening of food. Most currently available commercial IMS units have a resolving power of 10–60.

Polyimide coated fused silica capillary tubing is widely used in the separation sciences. In some instances a condition called brittleback can appear in the tubing. Its causes and remedies are discussed.

The FDA has made changes to how products containing sunscreen are labeled in the U.S. to ensure they meet the new regulations set forth for safety and effectiveness. The new regulations will require companies that want to use the "broad spectrum" label to test for both UVA and UVB protection.

Ascentis Express 5 micron columns provide a new choice for improving the performance of traditional HPLC systems. Based on Fused-Core particle technology, Ascentis Express provides the benefits of high speed and high efficiencies without the concerns of smaller particle columns. Due to the high efficiencies at low backpressures, Ascentis Express 5 micron can benefit conventional HPLC users with no drawbacks.

The efficiency of ion transfer between the quadrupole mass analyzers and the Q2 collision cell in a triple quadrupole mass spectrometry (MS) is critical for instrument robustness and sensitivity. Q2 is a radio frequency (RF) only non-mass filtering quadrupole containing only an inert collision gas such as Ar, He, or N2 to provide collision induced dissociation of the precursor ion selected in Q1.

When working with complex matrices such as personal care products, sample preparation is perhaps the most difficult step of the analysis process. By utilizing a targeted sample preparation technique, such as ion-exchange SPE, analysis can be significantly improved as compared to less targeted techniques such as liquid-liquid extraction.

Resistive glass tubes and plates are designed to guide ions by generating a uniform electric field. Photonis resistive glass products are composed of a proprietary lead silicate glass that has been specially processed to create a resistive layer at the surface. The resistivity can be varied over several orders of magnitude to suit the specific application.