Application Notes: General

The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.

This application demonstrates excellent performance in method development for the analysis of raw materials for oligonucleotide synthesis using a biocompatible UHPLC.

Six nitrosamines are separated using a YMC-Triart C18 UHPLC column. This is challenging due to the commonly observed small peaks thanks to low impurity concentrations.

A simple and sensitive method is presented for the analysis of glyphosate and its metabolite AMPA in drinking water, using the ALEXYS HPAEC-PAD analyzer.

The ALEXYS HPLC-ECD Analyzer was used for the assay of Streptomycin sulphate in commercial pharmaceutical preparations, according to the official USP monograph.

An easy method is described for the analysis of nitrate and nitrite (E249 - E252) in food products, using the ALEXYS HPLC-UV analyzer.

HPLC with electrochemical detection is the method of choice for water- and fat-soluble vitamin analysis including ubiquinols.

The sensitive analysis of carbohydrates in instant coffee, based on an adapted ISO 11292:1995 method, is shown using the ALEXYS Carbohydrates Analyzer.

A fast and sensitive method is described for the analysis of phytosterols (sterols and stanols) using the ALEXYS HPLC-ECD analyzer equipped with a BDD WE electrode.

Gentamicin sulphate analysis in pharmaceutical preparations according to the official USP (37-NF32) and EP monograph (8.0) using the ALEXYS HPLC-ECD analyzer.

Three variable lengths of oligo-DNA and phosphorothioated oligo-DNA separated without an ion pair reagent, using the Shodex™ HILICpak™ VT-50 2D.

This application note demonstrates that oligo analysis using ZipChip CE/MS offers a quick, dilute-and-shoot analysis without the need for toxic ion-pairing agents.

This application note demonstrates that oligo analysis using ZipChip CE/MS offers a quick, dilute-and-shoot analysis without the need for toxic ion-pairing agents.

Stereoisomeric separation between solifenacin succinate and its stereoisomers occurs using the Lux® 5 µm Amylose-1 Column according to the USP monograph.

Sildenafil citrate assay and organic impurities are identified as in the US Pharmacopeia (USP) monograph with both core-shell and fully porous C18 HPLC columns.

The successful enantiomeric separation is demonstrated between rivaroxaban and its enantiomer impurity, R enantiomer, using the Lux® 5 µm Cellulose-1 Chiral HPLC column.

Efficient separation of zolmitriptan from its enantiomeric Impurity A according to Ph. Eur. monograph 273 using a chiral LC column

The enantiomeric separation between sitagliptin phosphate and its S-enantiomer using Lux® 5 µm Amylose-1 chiral column according to USP monograph for sitagliptin phosphate.

We show the effective separation of Escitalopram Oxalate from its impurities and related substances according to European Pharmacopeia (Ph. Eur) Monograph 2733 using a fully porous LC column.

Separation of Everolimus from Sirolimus (Impurity A) according to European Pharmacopoeia (Ph. Eur) Monograph 2918 for determination of Impurity A using three batches of Kinetex® 2.7 μm C18 columns.

We demonstrate the analytical applicability of three LC columns to meet system suitability as set forth by the European Pharmacopoeia monograph for Diclofenac Sodium 1002.

In this study, we confirm the high selectivity of CPC and its capability to purify a set of key compounds and enrich several minor cannabinoids in a single step.

LPGC–MS is a technique that uses the MS vacuum system, along with a specially designed column setup, to lower pressure inside the entire column, speeding up analysis.

Investigating the effect of hydrogen and helium carrier gas across a range of column flow rates with different draw-out lenses for essential oil and volatile analysis

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HRAM MS that utilizes technology that significantly augments unknown analysis capabilities in MetID, untargeted metabolomics and lipidomics research.

This application note demonstrates a quantitative analysis of polymethyl methacrylate in a photocopy toner through a 4-point calibration curve.