Application Notes: General

NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.

This application note highlights the use of solid-phase extraction (SPE) coupled with LC–MS/MS for sample enrichment and quantitation of endocrine-disrupting chemicals.

This application note describes a rapid LC–MS/MS method for the separation and detection of 44 drug of abuse compounds in urine samples.

SEC–HRMS demonstrated for the analysis of an IdeZ digested mAb for specific identification of any posttranslational modifications specific to the hypervariable region.

This application note describes two methods for isopropyl alcohol impurities detection: USP recommended 42-min analysis, and a speed-optimized method in less than 6 min.

UniSpray is a novel atmospheric ionization technique that provides increased peak response, enabling ultra-trace detection of PFAS and other contaminants.

Purification of peptide-peptoid hybrids can be obtained by reversed-phase chromatography with excellent recovery and resolution.

Purification of a single-stranded RNA oligonucleotide by ion pair reversed-phase HPLC is demonstrated, achieving > 99% pure fraction pool with a yield of > 56%.

This app note introduces the use of the Nexera XS inert UHPLC, which utilizes a metal-free flow path for accurate and reproducible analysis of nucleotides.  

This technical report covers how a column packed with small particle material can be used to optimize an analytical method for monoclonal antibody aggregates. 

Using high-capacity sorptive extraction with TD–GC–MS analysis for flavour profiling of cider and potato chips, contrasting unflavoured and flavoured-added products

This app note introduces an analytical method for the separation of oligonucleotides of different length by ion-exchange chromatography using the Nexera XS Inert. 

This app note covers aggregate analysis using a Shimadzu Shim-pack™ BioDiol size-exclusion chromatography column with the Nexera XS inert UHPLC.  

This technical note shows how the PreOmics BeatBox enables the processing of large sample cohorts efficiently in as little as 10 min without sample cross-contamination.

This application note is the first reported separation of Fluoxetine on polysaccharide-based chiral HPLC columns, and it comes on Daicel’s newest column, CHIRALPAK® IK.

This application note features a unique, simple, and robust solid-phase extraction method for cannabinoids in urine followed by analysis by LC–MS/MS.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-elutes and avoid matrix interferences.

Application guide to PFAS analysis in environmental and food samples, from sample preparation to LC–MS/MS analysis, featuring both validated and exploratory methods