A recent study ascertained metabolic biomarkers and investigated the metabolic alterations associated with aqueous humor (AH) in wet age-related macular degeneration (AMD). Analysis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify and quantify metabolites.
Bram Huygens’ research focuses on developing a deeper understanding of the factors influencing separation efficiency by using advanced mathematical techniques to analyze mass transfer phenomena.
Amarande Murisier has earned recognition in the field of biopharmaceutical separation sciences with method development of SEC and IEC hyphenated with MS.
Alexandre Goyon specializes in developing advanced analytical methods to support new drug modalities.
Caitlin Cain has developed one-dimensional and comprehensive two-dimensional gas chromatographic methods using novel data analysis approaches.
A morning session at the International Symposium on Chromatography in Liverpool presented analytical challenges and potential solutions for PFAS analysis, oil pollution, and microplastics.
A new, fast, and accurate method to measure the levels of ivermectin in blood and plasma samples was developed using a new technique to prepare the samples and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze them.
The 34th International Symposium on Chromatography kicked off on October 6 in Liverpool, featuring two plenary sessions and an opening ceremony.
A recent study examined three drug overdose deaths resulting from an Italian prison riot during the initial wave of the SARS-CoV-2 pandemic. To ascertain the nature of these deaths, a comprehensive toxicological analysis was conducted, employing gas chromatography-mass spectrometry to reveal high concentrations of various substances in the biological fluids of the deceased inmates.
The influence of chitosan's physicochemical characteristics on the functionality of lactic acid bacteria and the production of lactic acid remains very obscure and contradictory to date, thus inspiring a research team to study the effect of chitosan on growth and productivity of that bacteria in its presence.
Changes in volatile compounds (VCs) during air frying of tilapia were researched in a recent study by quantitative gas chromatography–ion mobility spectrometry, followed by the identification of key VCs based on their odor activity value (OAV).
A recent study focused on identifying molecular markers capable of discriminating between different origins and, at the same time, predicting their sensory attributes adopting a sensomics approach. An untargeted method was adopted, based on the coupling of ultra-high performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS), followed by the application of chemometric tools for the selection of 71 discriminating molecular markers for six origins.
A recent study determined the insecticidal activity of essential oils (EOs) from leaves of P. aduncum cultivated in southeastern Brazil, collected during the dry and rainy seasons, against fleas. Through this research, researchers hope to promote the utilization of these natural resources, particularly those now in cultivation and available for industry, in ways that align with traditional practices.
Julien Crepier of TotalEnergies was one of the researchers that conducted this study, and he recently sat down with LCGC International to talk about his team’s findings.
A recent study focused on improving the flavor of beef from Xinjiang brown cattle utilized two-dimensional gas chromatography–time-of-flight mass spectrometry (GC×GC-TOF MS to analyze volatile flavor compounds across different beef cuts.
ACD/Labs, a leading informatics company specializing in software for digitalizing R&D, has announced the release of version 2024 of its Spectrus Platform applications.
A recent study investigated the significance of quantifying amino acids in minute sweat volumes using high performance liquid chromatography (HPLC) with fluorescence (FL) detection, offering a non-invasive and efficient way to screen for diseases by detecting amino acids in sweat, even with minimal sweat volumes.
In this edition of “Inside the Laboratory,” Betsy Stone, PhD, a professor of chemistry at the University of Iowa, discusses her group’s current research endeavors, including developing a new liquid chromatography–mass spectrometry (LC–MS) method to track secondary organic aerosol that forms in the atmosphere from D5.
The introduction of comprehensive two-dimensional gas chromatography (GC×GC) to the sample screening toolbox has substantially increased the ability to comprehensively characterize complex mixtures. However, for many gas chromatography (GC) users, the thought of having to learn to develop methods on a new technology is daunting. Developing a basic GC×GC method for most (nonspecialized) applications can be accomplished in minimal time and effort given parameter suggestions and ranges to target analytes in a sample of interest. In this article, the authors work describe a simple workflow to develop a GC×GC method for a specific sample upon initial use, with the aim of decreasing the time to accomplish functional workflows for new users.
Researchers built a reliable breath collection and analysis method using thermo-desorption gas chromatography-mass spectrometry (TD-GC–MS) that can produce a comprehensive list of known volatile organic compounds (VOCs) in the breath of a heterogeneous human population.
This year, the ISC’s theme is “Imagine a world of Chromatography." Here, we will see conference attendees discuss a wide variety of disciplines where chromatography plays a crucial role.
Petroleum contamination from leaking underground storage tanks, for example, is a significant concern for both the environment and human health. Thorough characterization of the contamination is required to form appropriate risk assessments and remediation strategies, but until now, the determination of total petroleum hydrocarbons (TPHs) in soil has typically involved a convoluted and labour-intensive process. In this article, the analysis of TPH in environmental media is simplified using flow-modulated GC×GC–FID with quantitation based on pre-defined compound groupings. This approach overcomes the drawbacks of conventional solvent fractionation approaches, by eliminating the need for sample fractionation and automating data processing workflows.
Column insertion distance is critical to good chromatography. What happens if the column is installed too low in the injection port? Is insertion distance more important when performing split injection or splitless injection? Does the position of the column in the injection port impact reproducibility?
A concise summary and celebration of the role of sample preparation for quantitative analysis in bioanalytical applications.
Researchers analyzed 31 different brands of hand sanitizers using headspace gas chromatography-mass spectrometry (GC–MS) to assess volatile impurities and ethanol content in ethanol-based hand sanitizers.
As data volumes and expectations for fast scientific discovery continue to increase, laboratory-based research organizations can no longer rely on a siloed approach to data management. To remain competitive, scientific organizations need to connect all their data, from discovery through manufacturing, in a unified informatics platform.
To gain insight into the effect of drying temperature on its composition, headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC–MS) was used for the identification of volatile organic compounds (VOCs) of 86 mushroom samples that were divided into five groups and dried at different temperatures.
A recent journal article provided an overview of a dataset that includes 10,000 experimental retention times, derived from 30 different reversed-phase liquid chromatography (LC) methods.
Researchers from the University of British Columbia have introduced an assay developed and validated to measure steroids in human primary teeth using liquid chromatography-tandem spectrometry (LC-MS/MS).
Click here to download the North America PDF of The Column September 2024 issue.
