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Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to determine the molar mass distribution of synthetic macromolecules. However, some kinds of polymers (for example, polyolefins) are often only soluble in special solvents and require high temperatures to be used during the analysis to keep the sample completely dissolved. Therefore, for the analysis of these polymers, dedicated high temperature GPC systems are used. This article will discuss the pros and cons of both high temperature GPC/SEC and ambient GPC/SEC.

An excerpt from LCGC’s professional development platform, CHROMacademy.com, on the importance of tuning and calibration in liquid chromatography–mass spectrometry (LC–MS).

The Community for the Analytical Measurement Science (CAMS) was officially launched on 27 June at the Royal Society of Chemistry, Burlington House, London, UK.

A new method for the accurate molecular weight determination of the complex polysaccharides chitosans has been developed using asymmetric AF4 coupled with MALS and differential RI detectors.

Shimadzu has received two Red Dot Design Awards in the product design category for its new Nexera UHPLC series LC-40 and UV-1900 UV–vis spectrophotometer.

Researchers from the University of Huddersfield present new data and announce further studies which show great potential for the development of a for a noninvasive multiple sclerosis diagnostic tool which uses GC–MS.

Click the title above to open the LCGC North America August 2019 issue, Volume 37, Number 8, in an interactive PDF format.

Click the title above to open the LCGC Europe August 2019 regular issue, Volume 32, Number 8, in an interactive PDF format.

Click the title above to open the August 2019 issue of the LCGC North America Annual Industry Trends & Directory Issue, Volume 37, Number 8, in an interactive PDF format.

To better understand modern sample preparation techniques-such as ultrasound-assisted extraction, microwave-assisted extraction, and pressurized solvent extraction-we should look at the lessons these methods took from Soxhlet extraction.

In LC–MS, the importance of tuning and calibrating the mass spectrometer cannot be overemphasized. There are six main aspects to address.

HILIC has rapidly evolved into a practical technique. For analyzing highly polar compounds, HILIC can be far more straightforward than GC or reversed-phase LC with derivatization, and can lead to a simpler final method with robustness comparable to that of reversed-phase LC.

Several regulatory data integrity guidance documents require that laboratories understand the data life cycle of their processes, but provide only vague definitions of what a data life cycle is. Here is a practical interpretation.

Direct coupling of ion-exchange separations to mass spectrometric (MS) detection is increasingly being used for analyses of molecules ranging from organic acids to proteins. These approaches leverage both the exquisite selectivity of the ion-exchange mode for charge-based separation, and the tremendous power of mass spectrometry for identification of unknowns and trace-level quantitation.

This instalment is the first of a series of four white papers on high performance liquid chromatography (HPLC) modules (pump, autosampler, UV detector, and chromatography data system) to be published in 2019. This instalment provides an overview for analytical-scale HPLC pumps, including their requirements, modern designs, operating principles, trends, and best practices for trouble-free operation.

The 12th Balaton Symposium on High‑Performance Separation Methods will be held 11–13 September 2019 in the Hotel Azúr in Siófok, Hungary.