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Click the title above to open the LCGC North America November 2017 regular issue, Vol 35 No 11, in an interactive PDF format.

A new nonprofit laboratory in Wilmington, Delaware, will provide laboratory space and access to experienced laboratory staff for entrepreneurs.

Lab Innovations has announced that science writer and broadcaster Adam Rutherford will be a keynote speaker at this year’s event held at the NEC in Birmingham, UK.

Ellutia Chromatography Solutions has opened a new dedicated training centre in Ely, Cambridgeshire, UK.

Researchers from The First Institute of Oceanography in Qingdao, China, have developed an exact mass suspect screening approach for identifying multiple lipophilic marine toxins in seawater, suspended particulate matter (SPM), and marine sediment using LC–TOF-MS.

Restek has been awarded company of the year by The Pennsylvania/Delaware Chapter of the ESOP Association during its annual conference on 14 September 2017.

Click the title above to open The Column October 24, 2017 Europe & Asia issue, Volume 13, Number 15, in an interactive PDF format.

Click the title above to open The Column October 24, 2017 North American issue, Volume 13, Number 15, in an interactive PDF format.

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Markes International has announced the opening of a new subsidiary in Shanghai, China.

Researchers from the University of Minnesota have investigated the effects of cold water immersion on athlete recovery in combat sports training using SCX HPLC and ELISA.

Incognito wonders if chromatographers are just plain lazy.

Pharmafluidics has announced the appointment of Fasha Mahjoor as an independent director.

Phenomenex Inc. has announced that it will begin to directly serve customers in Switzerland following the mutually agreed upon end of its 26-year-old partnership with local distributor Brechbühler AG.

The intensity of the light scattering signal depends on concentration, molar mass, and the specific refractive index increment, dn/dc, of the sample. dn/dc therefore usually needs to be known to derive molar masses by gel permeation chromatography/size-exclusion chromatography-light scattering (GPC/SEC-LS). How to overcome the issue of unknown refractive index increments is outlined in this instalment of Tips & Tricks. In particular, a new approach to derive molar masses by GPC/SEC-LS that requires only the molar mass of a reference material, and not the dn/dc of the sample or of the reference material, is introduced.

A preview of HTC-15, which will be held at Cardiff City Hall, Cardiff, United Kingdom, from 24–26 January 2018.

The three-day Chromatographic Society meeting was held on Monday 15th until Wednesday 17th May 2017 and was hosted by Pfizer at Discovery Park in Sandwich, Kent, UK. This comprehensive symposium featured oral presentations from leading practitioners of supercritical fluid chromatography (SFC) and ultrahigh-pressure liquid chromatography (UHPLC) from across Europe. Some of the latest innovations and applications were described and the lectures were augmented and supported by a comprehensive exhibition of instrumentation and consumables. The attendees gained insight into practical application of these techniques across a variety of industries, particularly the pharmaceutical industry. The comprehensive programme had a significant focus on SFC for chiral and preparative-scale analysis.

Click the title above to open The Column October 10, 2017 North American issue, Volume 13, Number 14, in an interactive PDF format.

Click the title above to open The Column October 10, 2017 Europe & Asia issue, Volume 13, Number 14, in an interactive PDF format.

Data validity and a thorough understanding of the results that we produce should be of great interest to us all. Here's why.

Click the title above to open the LCGC Europe October 2017 supplement, Vol 30, No s10, in an interactive PDF format.

Click the title above to open the LCGC North America October 2017 Advancing Environmental Analysis, Vol 35 No s10, in an interactive PDF format.

To resolve and quantitate monoclonal antibodies and antibody–drug conjugates, analytical scientists need various chromatographic modes, such as sizeexclusion, ion-exchange, hydrophobic interaction, and hydrophilic interaction chromatography. Here, we provide advice for making the most of each mode.

Systematic toxicological analysis is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using nontargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification.

In his final column before retirement, John Dolan reminisces about his years as the author of “LC Troubleshooting”, and some of the changes that have taken place in liquid chromatography (LC) technology during that time.

Separating proteins and antibodies is a unique analytical challenge because of the complexity of the analytes. Both sample heterogeneity, because of a number of chemical modifications to the analyte, and nonspecific binding to the silica surface often result in chromatographic peak broadening and tailing. This instalment of “Column Watch” focuses on several different chromatographic strategies that analytical scientists can use to resolve and quantitate various biomacromolecules, including monoclobal antibodies (mAbs) and antibody–drug conjugates (ADCs). Selected aspects of size-exclusion, hydrophobic interaction, ion-exchange, hydrophilic interaction, and reversed-phase chromatography are discussed.