The Application Notebook-09-02-2015
The Application Notebook
Vol 33 No 9 LCGC North America September 2015 Application Notebook PDF
September 02, 2015
Issue PDF
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Click the title above to open the LCGC North America September 2015 Application Notebook, Vol 33 No s9, in an interactive PDF format.
Characteristics and Application of a Chiral Column, Chiral CD-Ph
September 01, 2015
Chiral
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In recent years, in the course of pharmaceuticals purified, as the need to chiral purification decreased since the improving of the asymmetric synthetic techniques, the desire to make medicine effective yet with a smaller number of doses and promised safety has raised
Pressurized Liquid Extraction of Soil Samples for the Analysis of Diesel Range Organics by GC–FID
September 01, 2015
Environmental
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Diesel range organics or DRO is the cumulative analysis of extractable alkanes between the ranges C10 through C28 as measured on a flame ionization detector.
An Automated Extraction Solution
September 01, 2015
Environmental
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This project will evaluate the performance and versatility of the AutoMate-Q40 for the extraction of Imidazolinone herbicides.
Hexavalent Chromium Determination Hamilton
September 01, 2015
Environmental
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Analysis of chromium species is made challenging due to the nature of the element and diverse sample matrices
Analysis of L-Theanine in Tea by HPLC with Post-Column Derivatization
September 01, 2015
Food & Beverage
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Theanine is a neurologically active amino acid found in tea plants. L-Theanine is a dominant amino acid in green tea and is responsible for its unique pleasant taste as well as known relaxation effect.
Aflatoxin B1, B2, G1, G2 Food Safety Testing Prior to Automated SmartPrep® Extractor Solid-Phase Extraction
September 01, 2015
Food & Beverage
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Mycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply
A New HILIC Column for Saccharide Analysis
September 01, 2015
Food & Beverage
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Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).
Ex vivo Stabilization of Small Molecule Compounds and Peptides in EDTA Plasma for LC–MS-MS Analysis Using Frozen Aliquotting
September 01, 2015
Pharmaceutical and Drug Discovery
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The ex vivo lability of some drug compounds and molecules in bio-analytical assays can add complexity and uncertainty to results and can pose significant challenges in drug development efforts.
Fast Analysis of IgG Charge Heterogeneity by Ion Exchange Chromatography
September 01, 2015
Pharmaceutical and Drug Discovery
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Therapeutic antibodies are enjoying high growth rates in the pharmaceutical market. A majority of the top bestselling global drug brands are monoclonal antibodies (mAbs).
Faster Analysis and Higher Efficiency with Thermally Stable HPLC Columns
September 01, 2015
Pharmaceutical and Drug Discovery
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In his article, published in 2000, David V. McCalley found large increases in the efficiency for basic compounds at elevated temperature
Light Scattering for the Masses: Quality Control of Epoxy Resins
September 01, 2015
Polymer
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Traditionally, simple analytical characteristics (for example, content of epoxy groups, chlorine, α-glycol groups, viscosity or softening point) are used to identify epoxy resins.
Nanometer Internal Diameter Fused Silica Capillary Tubing
September 01, 2015
General
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Scientists employ fused silica capillary tubing routinely in a wide range of analytical applications, encompassing GC, CE, capillary LC, and CEC. It has proven as an ideal substrate for interfacing in hyphenated techniques.
Accurate Pain Management Analysis in Under 5 Min on Raptor Biphenyl Superficially Porous Particle LC Columns
September 01, 2015
Pharmaceutical and Drug Discovery
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Complete separation of critical pain management drug analytes from hydrophilic matrix components and isobaric interferences was achieved using the new Raptor™ SPP Biphenyl LC column in less than 5 min
Separation of Macrocyclic Lactones
September 01, 2015
Pharmaceutical and Drug Discovery
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Avermectins are a series of 16-membered macrocyclic lactone derivatives that are used extensively in animal and crop protection
Authentication of Traditional Chinese Prescriptions Using Comprehensive 2D-LC
September 01, 2015
Pharmaceutical and Drug Discovery
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enable authentication of Si-Wu-Tang, a separate comprehensive 2D-LC analysis of each herb contained in Si-Wu-Tang was performed.
The Application of QuEChERS in the Extraction of Anabolic Steroids in Whole Blood
September 01, 2015
Medical & Biological
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This application utilizes the original, non-buffered QuEChERS (acronym for quick, easy, cheap, effective, rugged, and safe) technique to quantify anabolic steroids in human whole blood
Versatility of the Multi-Mode Scherzo SS-C18 in the Retention of Polar Neurotransmitters
September 01, 2015
Medical & Biological
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Polar neurotransmitters are difficult to retain using ODS columns. In this work we show two different methods to retain these polar analytes on the multi-mode Scherzo SS-C18 column. The versatility in retention characteristics with simple changes in mobile phase is highlighted.
Detection of Chiral Drugs Using HPLC with CD Detection
September 01, 2015
Chiral
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The need for chiral detection in the development of pharmaceuticals is increasing due to regulatory changes and the demand for single-isomer pharmaceutical drugs
Vol 28 No 9 LCGC Europe September 2015 Application Notebook PDF
May 02, 2015
Issue PDF
0
Click the title above to open the LCGC Europe September 2015 Application Notebook, Vol 27 No s9, in an interactive PDF format.